Zobrazeno 1 - 10
of 1 117
pro vyhledávání: '"Michael J. Owens"'
Autor:
Jeremy D. Coplan, Anna V. Rozenboym, Sasha L. Fulton, Venkatesh Panthangi, Jean Tang, Lakshmi Thiramangalakdi, Tarique D. Perera, Yang Liu, Haroon Kamran, Michael J. Owens, Charles B. Nemeroff, Leonard A. Rosenblum, John G. Kral, Louis Salciccioli, Jason Lazar
Publikováno v:
Neurobiology of Stress, Vol 8, Iss , Pp 202-210 (2018)
Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a “thrifty phenotype” throughout the life cycle. For instance, ELS induces persistent increases in
Externí odkaz:
https://doaj.org/article/50ad0514097d412b8c9d7de467326a41
Autor:
Jeremy D. Coplan, Dunyue Lu, Alexander M. El Sehamy, Cheuk Tang, Andrea P. Jackowski, Chadi G. Abdallah, Charles B. Nemeroff, Michael J. Owens, Sanjay J. Mathew, Jack M. Gorman
Publikováno v:
Chronic Stress, Vol 2 (2018)
Introduction Using proton magnetic resonance spectroscopy imaging, the effects of early life stress on nonhuman primate striatal neuronal integrity were examined as reflected by N -acetyl aspartate (NAA) concentrations. NAA measures were interrogated
Externí odkaz:
https://doaj.org/article/ca9a57a9b4c8445781af1faa0ceacf01
Publikováno v:
Neuroendocrinology
Introduction: Activation of the locus coeruleus-noradrenergic (LC-NA) system during awakening is associated with an increase in plasma corticosterone and cardiovascular tone. These studies evaluate the role of the LC in this corticosterone and cardio
Autor:
Jason Lazar, Anna V. Rozenboym, Sasha L. Fulton, Lakshmi Thiramangalakdi, Haroon Kamran, Jean Tang, John G. Kral, Venkatesh Panthangi, Jeremy D. Coplan, Tarique D. Perera, Michael J. Owens, Yang Liu, Charles B. Nemeroff, Leonard A. Rosenblum, Louis Salciccioli
Publikováno v:
Neurobiology of Stress, Vol 8, Iss, Pp 202-210 (2018)
Neurobiology of Stress
Neurobiology of Stress
Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a “thrifty phenotype” throughout the life cycle. For instance, ELS induces persistent increases in
Autor:
Boadie W. Dunlop, Mark M. Goodman, Vikram Adhikarla, Jonathon A. Nye, Nashwa Jarkas, Michael J. Owens, Helen S. Mayberg
Publikováno v:
Journal of Nuclear Medicine. 59:315-319
The aim of this study was to measure the test–retest reliability of 11C-N,N-dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine (11C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy control subjects. Methods: Two fema
Autor:
Eric P. Smith, Leonard A. Rosenblum, Shariful A. Syed, Michael J. Owens, Olcay Batuman, Charles B. Nemeroff, Jeremy D. Coplan
Publikováno v:
Neuroscience Letters. 647:20-25
Introduction Early life stress (ELS) has been shown to play a role in establishing persistent maladaptive HPA axis modifications that may contribute to the pathogenesis of mood and anxiety disorders. Central glucocorticoid receptor (GR) messenger RNA
Autor:
Ronald J. Voll, Michael A. Wassef, Jeffrey S. Stehouwer, Clinton D. Kilts, Michael J. Owens, Chase H. Bourke, Susan J Plott, Mark M. Goodman, Matthew S. Birnbaum
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115660
Autor:
Ronald J. Voll, Clinton D. Kilts, Jeffrey S. Stehouwer, Chase H. Bourke, Mark M. Goodman, Michael J. Owens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5111-5114
Compounds 1-14 were synthesized in a search for high-affinity CRF1 receptor ligands that could be radiolabeled with (11)C or (18)F for use as positron emission tomography (PET) radiotracers. Derivatives of 2 were developed which contained amide N-flu
Autor:
Vikram, Adhikarla, Boadie W, Dunlop, Nashwa, Jarkas, Mark M, Goodman, Helen, Mayberg, Michael J, Owens, Jonathon A, Nye
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 59(2)
The aim of this study was to measure the test–retest reliability of 11C-N,N-dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine (11C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy control subjects. Methods: Two fema
Autor:
Michael J. Detke, Graeme Eisenhofer, Jill Chappell, Robert A. Dean, Mary Pat Knadler, D. Richard Lachno, Malcolm I. Mitchell, Beth A. Pangallo, Smriti Iyengar, Evelyn D. Lobo, Charles B. Nemeroff, Harry Haber, Michael J. Owens
Publikováno v:
Journal of Clinical Psychopharmacology. 34:9-16
Duloxetine selectively inhibits the serotonin (5-HT) and norepinephrine (NE) transporters (5-HTT and NET, respectively), as demonstrated in vitro and in preclinical studies; however, transporter inhibition has not been fully assessed in vivo at the a