Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael J. Ophir"'
Autor:
Stephen C. Bunnell, Keith P. Eidell, Alenka Lovy, Ken Nguyen, Frank A Scangarello, Michael J. Ophir, Maria-Cristina Seminario, Hayley I. Muendlein, Nicholas R. Sylvain
Publikováno v:
J Cell Sci
Integrin engagement within the immune synapse enhances T cell activation, but our understanding of this process is incomplete. In response to T cell receptor (TCR) ligation, SLP-76 (LCP2), ADAP (FYB1) and SKAP55 (SKAP1) are recruited into microcluste
Autor:
Michael J. Ophir, Michelle O. Sodipo, Joanne M. Murphy, Juliana B. Lewis, Frank A Scangarello, Stephen C. Bunnell, Keith P. Eidell, Ryan Sargeant, Maria-Cristina Seminario
Publikováno v:
Journal of Cell Science.
Antigen recognition by the T cell receptor (TCR) directs the assembly of essential signaling complexes known as SLP-76 (also known as LCP2) microclusters. Here, we show that the interaction of the adhesion and degranulation-promoting adaptor protein
The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms
Publikováno v:
The Journal of Cell Biology
In addition to promoting integrin activation at the immunological synapse, SKAP55 links T cell antigen receptor-associated signaling molecules to the cytoskeleton and promotes integrin-independent adhesion via the T cell receptor.
The T cell rec
The T cell rec
Autor:
Julia L. Chen, Philip D. Manos, Timothy J. Levesque, Farrah M. Laliberte, Joseph A. Lee, Michael J. Ophir, Kyle M. Judkins, Geoffrey C. Collins, Edmund Y. Tong, April E. Greene-Colozzi
Publikováno v:
Zebrafish. 6(3)
Existing methods to quantify angiogenesis range from image analysis of photographs to fluorescent microscopy. These methods are often time consuming and costly; they also may not detect capillaries if they are indistinct from the background of the im