Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michael J. Niedbala"'
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb2a4d859543d18252213a2d5a9b54c
https://doi.org/10.1021/acs.jmedchem.2c00369
https://doi.org/10.1021/acs.jmedchem.2c00369
Autor:
Jason G, Kettle, Sharan K, Bagal, Sue, Bickerton, Michael S, Bodnarchuk, Scott, Boyd, Jason, Breed, Rodrigo J, Carbajo, Doyle J, Cassar, Atanu, Chakraborty, Sabina, Cosulich, Iain, Cumming, Michael, Davies, Nichola L, Davies, Andrew, Eatherton, Laura, Evans, Lyman, Feron, Shaun, Fillery, Emma S, Gleave, Frederick W, Goldberg, Lyndsey, Hanson, Stephanie, Harlfinger, Martin, Howard, Rachel, Howells, Anne, Jackson, Paul, Kemmitt, Gillian, Lamont, Scott, Lamont, Hilary J, Lewis, Libin, Liu, Michael J, Niedbala, Christopher, Phillips, Radek, Polanski, Piotr, Raubo, Graeme, Robb, David M, Robinson, Sarah, Ross, Matthew G, Sanders, Michael, Tonge, Rebecca, Whiteley, Stephen, Wilkinson, Junsheng, Yang, Wenman, Zhang
Publikováno v:
Journal of medicinal chemistry. 65(9)
KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now rendered this important GTPase druggable. Herein, we report our structure-based drug design appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c82ffa8ba3350b52cfb57034d024ef1
https://pubmed.ncbi.nlm.nih.gov/35471939
https://pubmed.ncbi.nlm.nih.gov/35471939
Publikováno v:
Blood. 81:2608-2617
Tumor necrosis factor (TNF) can promote endothelial cell transcription, synthesis, and secretion of urokinase plasminogen activator (uPA) augmenting extracellular matrix remodeling and influencing cellular differentiation. In this report, the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b88d0d1ffdd94d840a134dbf43a0a219
https://doi.org/10.1182/blood.v81.10.2608.2608
https://doi.org/10.1182/blood.v81.10.2608.2608
Publikováno v:
Blood. 79:678-687
Tumor necrosis factor (TNF) has a profound capacity to alter the endothelial cell phenotype that includes morphologic and functional changes that may be central for proinflammatory processes. Recent observations have indicated that TNF can promote th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a606ba4e28b1e5389187a653e92d1472
https://doi.org/10.1182/blood.v79.3.678.bloodjournal793678
https://doi.org/10.1182/blood.v79.3.678.bloodjournal793678
Publikováno v:
Arthritis and rheumatism. 39(9)
Objective. To determine the expression of matrix metalloproteinase 9/gelatinase B (MMP-9) in synovial fluid (SF), plasma, and synovial tissue from individuals with rheumatoid arthritis (RA), inflammatory arthritis (IA), and osteoarthritis (OA), using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ddc7cc253a164a06b1b5f6c33e52cd
https://pubmed.ncbi.nlm.nih.gov/8814070
https://pubmed.ncbi.nlm.nih.gov/8814070
Publikováno v:
Annals of the New York Academy of Sciences. 732
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c3037a602f3577a08d682f0b8a46fd
https://pubmed.ncbi.nlm.nih.gov/7978846
https://pubmed.ncbi.nlm.nih.gov/7978846
Publikováno v:
American journal of respiratory cell and molecular biology. 7(6)
Primary cultures of peripheral lung lobes were grown in a highly supplemented medium. Human lung endothelial cells (HLE) were isolated from the mixed population by FACS. The cells proliferated rapidly and were serially cultivated for at least 16 pass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fe7cf959c030ea19a6b8f99b76f31f
https://pubmed.ncbi.nlm.nih.gov/1333246
https://pubmed.ncbi.nlm.nih.gov/1333246
Publikováno v:
Biological chemistry Hoppe-Seyler. 373(7)
Morphological and functional changes in the endothelial cell phenotype which may be central to proinflammatory processes can be elicited by tumor necrosis factor alpha (TNF). Recent observations have indicated that TNF can promote the expression, syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7ff86851c56f361fb97e829521a300
https://pubmed.ncbi.nlm.nih.gov/1381189
https://pubmed.ncbi.nlm.nih.gov/1381189
Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix
Publikováno v:
Experimental Cell Research. 160:499-513
Human ovarian tumors metastasize by direct extension into the peritoneal cavity leading to tumor cell implantation onto peritoneal surfaces. Successful formation of peritoneal implants is dependent on the ability of ascitic tumor cells to infiltrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b6a1b2eddeaa9391110131919c2740
https://doi.org/10.1016/0014-4827(85)90197-1
https://doi.org/10.1016/0014-4827(85)90197-1
Publikováno v:
Clinical & Experimental Metastasis. 5:181-197
Better in vitro models are needed to elucidate the mechanisms underlying tissue destruction by human tumor cells. To address this matter recently isolated and characterized human ovarian carcinoma cell lines derived from either primary tumors, asciti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95229301cc552b54847e7432a5f989f1
https://doi.org/10.1007/bf00058063
https://doi.org/10.1007/bf00058063