Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael J. Neat"'
Autor:
Elena Ortiz-Zapater, Richard W Lee, William Owen, Gregory Weitsman, Gilbert Fruhwirth, Robert G Dunn, Michael J Neat, Frank McCaughan, Peter Parker, Tony Ng, George Santis
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170798 (2017)
Advanced lung cancer has poor survival with few therapies. EGFR tyrosine kinase inhibitors (TKIs) have high response rates in patients with activating EGFR mutations, but acquired resistance is inevitable. Acquisition of the EGFR T790M mutation cause
Externí odkaz:
https://doaj.org/article/a06a6d023de24f69b2ac4b5eeff0ab78
Autor:
E. Karapanagiotou, Aled Jones, Daniel J. Smith, James Spicer, D.J. Hughes, Athanasios Diamantopoulos, Gary Cook, Juliet King, Michael J. Neat, Alexandros Georgiou, Emma McLean, George Santis
Publikováno v:
Current Problems in Cancer: Case Reports. 4:100106
Activating epidermal growth factor receptor gene mutations (EGFRm) are relatively common in non-small cell lung cancer (NSCLC) and are predictive of superior outcomes with EGFR tyrosine kinase inhibitors (TKIs). Eventually, acquired genetic or phenot
Autor:
Michael J. Neat
Publikováno v:
Diagnostic Histopathology. 21:198-202
Fluorescence in situ hybridisation (FISH) analysis is now widely employed in the diagnosis and risk stratification of a wide range of malignant diseases. While this technique is used successfully with formalin-fixed paraffin-embedded (FFPE) sections
Autor:
Simon Crouch, Penny Wright, Jenny Buxton, Nicholas Francis Grigoropoulos, Ming-Qing Du, Bridget S. Wilkins, Yuanxue Huang, Andrew Jack, A. James Watkins, Michael J. Neat, Paul Fields, Lisa Worrillow, Sharon Barrans, Peter Johnson, Sylvia Kocialkowski, Hongxiang Liu, Alexandra Clipson, Eve Roman, Hesham EI‐Daly, John R. Goodlad, George A Follows, John W Grant, Ming Wang, Naiyan Zeng
Publikováno v:
The Journal of Pathology: Clinical Research. 1:125-133
A proportion of MYC translocation positive diffuse large B-cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double-hit DLBCL, and are clinically aggressive. It is unknown whether there are other genetic abnormalities that coo
Autor:
Michael J. Neat, Alexander Hicks, George Santis, Nicola J Foot, Emma McLean, Ronan Breen, Bridget S. Wilkins
Publikováno v:
Cytopathology. 24:356-364
Objectives Patients with non-small cell lung cancer (NSCLC) positive for anaplastic lymphoma kinase (ALK) gene rearrangements may be treated successfully with the ALK inhibitor crizotinib. ALK copy-number abnormalities have also been described. In th
Autor:
Michael J. Neat, Bridget S. Wilkins, Barry Newell, Robert G Dunn, Lorrette Ffolkes, Nicola J Foot
Publikováno v:
Journal of Clinical Pathology. 66:357-360
Transformation of follicular lymphoma (FL) into high-grade B-cell non-Hodgkin lymphoma, usually diffuse large B-cell lymphoma (DLBCL), occurs in 25–35% of patients.1 This transformation has been shown to occur as a result of gain of MYC (8q24) rear
Publikováno v:
Journal of Clinical Pathology. 64:802-808
Aims In recent years the genetic aberrations associated with diffuse large B-cell lymphoma and the new subtype described in the 2008 revision of the WHO classification, ‘B-cell lymphoma, unclassifiable, with features intermediate between diffuse la
Autor:
Amanda Dixon-McIver, Matthew L. Smith, T. Andrew Lister, Ama Z. S. Rohatiner, J. A. L. Amess, Michael J. Neat, Maxine Cambal-Parrales, Jennifer Snaddon, Rachael Arch, Jude Fitzgibbon
Publikováno v:
Genes, Chromosomes and Cancer. 37:72-78
CEBPA encodes the transcription factor C/EBPα and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t
Autor:
Andrew Lister, Loretta Byrne, Christopher D Dalley, J. A. L. Amess, Nicola J. Foot, Bryan D. Young, Ama Z. S. Rohatiner, Debra M. Lillington, Michael J. Neat, Margaret Burridge
Publikováno v:
The Hematology Journal. 3:290-298
Comparative genomic hybridization (CGH) and multiplex-fluorescence in situ hybridization (M-FISH) were used to evaluate the presentation karyotype in 15 and 18 patients respectively, aged >/=60 years, with acute myeloid leukemia (AML). Conventional G
Autor:
Richard W J Lee, Elena Ortiz-Zapater, George Santis, Tony Ng, Frank McCaughan, Michael J. Neat, Gilbert O. Fruhwirth, Gregory Weitsman, Peter J. Parker, W. Owen, Robert G Dunn
Publikováno v:
Ortiz-Zapater, E, Lee, R W, Owen, W, Weitsman, G, Fruhwirth, G, Dunn, R G, Neat, M J, McCaughan, F, Parker, P, Ng, T & Santis, G 2017, ' MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition ', PLoS ONE, vol. 12, no. 1, pp. e0170798 . https://doi.org/10.1371/journal.pone.0170798
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170798 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170798 (2017)
Advanced lung cancer has poor survival with few therapies. EGFR tyrosine kinase inhibitors (TKIs) have high response rates in patients with activating EGFR mutations, but acquired resistance is inevitable. Acquisition of the EGFR T790M mutation cause