Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Michael J. Mitchell"'
Autor:
Alexander Chan, Rebecca M. Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J. Bugaj, George M. Burslem, Michael J. Mitchell, Andrew Tsourkas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Recently, targeted degradation has emerged as a powerful therapeutic modality. Relying on “event-driven” pharmacology, proteolysis targeting chimeras (PROTACs) can degrade targets and are superior to conventional inhibitors against undru
Externí odkaz:
https://doaj.org/article/c8e03480a79f42f1b05ddadc6ec0b9d3
Autor:
Gan Zhao, Maria E. Gentile, Lulu Xue, Christopher V. Cosgriff, Aaron I. Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P. Holcomb, Maria C. Basal, Kathleen M. Stewart, Joseph D. Planer, Edward Cantu, Jason D. Christie, Maria M. Crespo, Michael J. Mitchell, Nuala J. Meyer, Andrew E. Vaughan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Inflammation induced by lung infection is a double-edged sword, moderating both anti-viral and immune pathogenesis effects; the mechanism of the latter is not fully understood. Previous studies suggest the vasculature is involved in tissue i
Externí odkaz:
https://doaj.org/article/298e4f96eba74047b28b7e392be57e41
Autor:
Xuexiang Han, Junchao Xu, Ying Xu, Mohamad-Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan El-Mayta, Rohan Palanki, Claude C. Warzecha, Gan Zhao, Andrew E. Vaughan, James M. Wilson, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devi
Externí odkaz:
https://doaj.org/article/5c7c469fc7ef44afbf32232dfd7a12e4
Autor:
Lulu Xue, Alex G. Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G. Figueroa-Espada, Sarah J. Shepherd, Alvin J. Mukalel, Mohamad-Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E. Vaughan, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lipid nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the pulmonary delivery profile of ch
Externí odkaz:
https://doaj.org/article/5610f990ab3349ad8170012a73e2cbb4
Autor:
Lays Cordeiro Guimaraes, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa Athaydes Seabra Ferreira, Ana Carolina Soares Braga, Leonardo Camilo de Oliveira, Maria Marta Figueiredo, Sarah Shepherd, Alex Hamilton, Celso Martins Queiroz-Junior, Walison Nunes da Silva, Natália Jordana Alves da Silva, Marco Túllio Rodrigues Alves, Anderson Kenedy Santos, Kevin Kelton Santos de Faria, Fernanda Martins Marim, Heidge Fukumasu, Alexander Birbrair, Andréa Teixeira-Carvalho, Renato Santana de Aguiar, Michael J. Mitchell, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Frederic Frezard, Pedro Pires Goulart Guimaraes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract A safe and effective vaccine with long-term protection against SARS-CoV-2 variants of concern (VOCs) is a global health priority. Here, we develop lipid nanoparticles (LNPs) to provide safe and effective delivery of plasmid DNA (pDNA) and sh
Externí odkaz:
https://doaj.org/article/6e21773ab2fa44cfa142124a63708ee7
Autor:
Pedro Augusto Carvalho Costa, Walison Nunes da Silva, Pedro Henrique Dias Moura Prazeres, Heloísa Athaydes Seabra Ferreira, Natália Jordana Alves da Silva, Maria Marta Figueiredo, Bruna da Silva Oliveira, Sérgio Ricardo Aluotto Scalzo Júnior, Felipe Rocha da Silva Santos, Rúbia Aparecida Fernandes, Rohan Palanki, Alex G. Hamilton, Alexander Birbrair, Victor Rodrigues Santos, Aline Silva de Miranda, Michael J. Mitchell, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Pedro Pires Goulart Guimarães
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 115981- (2024)
CXCL12 is a key chemokine implicated in neuroinflammation, particularly during Zika virus (ZIKV) infection. Specifically, CXCL12 is upregulated in circulating cells of ZIKV infected patients. Here, we developed a lipid nanoparticle (LNP) to deliver s
Externí odkaz:
https://doaj.org/article/155029e401784155aeb7601f08e6e90b
Autor:
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1429-1437 (2023)
Evasion of apoptosis is a hallmark of cancer, attributed in part to overexpression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). In a variety of cancer types, including lymphoma, Bcl-2 is overexpressed. Therapeutic targeting of Bcl-2 has d
Externí odkaz:
https://doaj.org/article/ed334e7eb9604a24bf63a6a47cd80494
Autor:
Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M. Billingsley, Rakan El-Mayta, Sarah J. Shepherd, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Gene delivery to fibroblasts for liver fibrosis treatment remains challenging. Here the authors develop a combinatorial library of ligand-tethered lipidoids via a modular synthetic method and adopt a 2-round screening strategy to identify lipidoids f
Externí odkaz:
https://doaj.org/article/81996ac972bd4186941bbb28373c56ae
Autor:
Richard Fisher, Gary W. Moore, Michael J. Mitchell, Letian Dai, Siobhan Crichton, Nuttha Lumlertgul, Marlies Ostermann
Publikováno v:
Annals of Intensive Care, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Background Regional citrate anticoagulation (RCA) is recommended for continuous renal replacement therapy (CRRT). However, filter life varies and premature filter clotting can occur. The aims of this explorative prospective study were to inv
Externí odkaz:
https://doaj.org/article/fb3e6c455d1241418e139ec9b60ad87b
Autor:
Xuexiang Han, Hanwen Zhang, Kamila Butowska, Kelsey L. Swingle, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future developm
Externí odkaz:
https://doaj.org/article/2078c7804ee7479387552ef0bdd9efde