Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael J. Mihalevic"'
Autor:
Lucía F. Zacchi, John C. Dittmar, Michael J. Mihalevic, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1129-1140 (2017)
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of dystonia is early-onset torsion dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Externí odkaz:
https://doaj.org/article/f7ac7a235cf04b5ba2e8af83825ca350
Autor:
Rohit, Prakash, Yashpal, Rawal, Meghan R, Sullivan, McKenzie K, Grundy, Hélène, Bret, Michael J, Mihalevic, Hayley L, Rein, Jared M, Baird, Kristie, Darrah, Fang, Zhang, Raymond, Wang, Tiffany A, Traina, Marc R, Radke, Scott H, Kaufmann, Elizabeth M, Swisher, Raphaël, Guérois, Mauro, Modesti, Patrick, Sung, Maria, Jasin, Kara A, Bernstein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(38)
Mutations in homologous recombination (HR) genes, including
Publikováno v:
DNA Repair. 62:8-17
Yeast Cdc13 protein (related to human CTC1) maintains telomere stability by preventing 5′-3′ end resection. While Cdc13 and Yku70/Yku80 proteins appear to prevent excessive resection, their combined contribution to maintenance of telomere ends ac
Autor:
Kara A. Bernstein, Nathan L. Clark, Meghan R. Sullivan, Stefanie Böhm, Faiz F. Kabbinavar, Michael J. Mihalevic, Barnabas Szakal, Dana Branzei, Benjamin W. Herken
Publikováno v:
Journal of Biological Chemistry. 291:4442-4452
DNA damage must be repaired in an accurate and timely fashion to preserve genome stability. Cellular mechanisms preventing genome instability are crucial to human health because genome instability is considered a hallmark of cancer. Collectively refe
Publikováno v:
Journal of Cell Science.
The TORC1 complex is a key regulator of cell growth and metabolism in Saccharomyces cerevisiae . The vacuole-associated EGO complex couples activation of TORC1 to the availability of amino acids, specifically glutamine and leucine. The EGO complex is
Autor:
John C. Dittmar, Jeffrey L. Brodsky, Annette M. Shewan, Michael J. Mihalevic, Lucia F. Zacchi, Benjamin L. Schulz, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms.
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of Dystonia is Early-Onset Torsion Dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Autor:
Stephen K. Godin, Robert W. Sobol, Kara A. Bernstein, Michael A. Resnick, Zhuying Zhang, Michael J. Mihalevic, James W. Westmoreland, Zhongxun Yu, Benjamin W. Herken, Alison G. Lee
Publikováno v:
Nucleic Acids Research
Here, we investigate the role of the budding yeast Shu complex in promoting homologous recombination (HR) upon replication fork damage. We recently found that the Shu complex stimulates Rad51 filament formation during HR through its physical interact
Autor:
Michael J. Mihalevic, Meghan R. Sullivan, Jared M. Baird, Maria Jasin, Kara A. Bernstein, Rohit Prakash
Publikováno v:
Clinical Cancer Research. 24:A08-A08
Homologous recombination (HR) deficiency is associated with hereditary ovarian carcinomas. HR deficiency can occur through somatic and germline mutations in BRCA1, BRCA2, and other associated genes such as RAD51C. Understanding the impact of HR gene
Autor:
Huan Chen, Lorraine S. Symington, Ivana Sunjaveric, Eleni P. Mimitou, Rodney Rothstein, Kara A. Bernstein, Michael J. Mihalevic
Publikováno v:
Genetics. 195(4)
The RecQ helicase family is critical during DNA damage repair, and mutations in these proteins are associated with Bloom, Werner, or Rothmund-Thompson syndromes in humans, leading to cancer predisposition and/or premature aging. In the budding yeast