Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Michael J. McConnell"'
Autor:
Chen Sun, Kunal Kathuria, Sarah B. Emery, ByungJun Kim, Ian E. Burbulis, Joo Heon Shin, Brain Somatic Mosaicism Network, Daniel R. Weinberger, John V. Moran, Jeffrey M. Kidd, Ryan E. Mills, Michael J. McConnell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development,
Externí odkaz:
https://doaj.org/article/3c1b3462f5dc401c808fdd785991305a
Publikováno v:
Vaccines, Vol 12, Iss 1, p 68 (2024)
The emergence and global dissemination of bacterial strains from numerous species with resistance to multiple antibiotic classes has increased in recent years, both in the healthcare and the community setting [...]
Externí odkaz:
https://doaj.org/article/7c110fecf62545a49f453f30cb2b8bd4
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/c40866f9013a42d98d358c195d9110ce
Autor:
Mireia López-Siles, Zaira Moure, Aly Salimo Muadica, Sergio Sánchez, Raquel Cruces, Alicia Ávila, Noelia Lara, Pamela Carolina Köster, Alejandro Dashti, Jesús Oteo-Iglesias, David Carmena, Michael J. McConnell
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
BackgroundExtended-spectrum ß-lactamase-producing Enterobacterales (ESBL-E) are a serious threat among emerging antibiotic resistant bacteria. Particularly, the number of cases of ESBL-E infections reported in children has been increasing in recent
Externí odkaz:
https://doaj.org/article/d525c71757884b8185c5e9f196477947
Autor:
Nadine Michel, Heather M. Raimer Young, Naomi D. Atkin, Umar Arshad, Reem Al-Humadi, Sandeep Singh, Arkadi Manukyan, Lana Gore, Ian E. Burbulis, Yuh-Hwa Wang, Michael J. McConnell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Neurons are overproduced during cerebral cortical development. Neural progenitor cells (NPCs) divide rapidly and incur frequent DNA double-strand breaks (DSBs) throughout cortical neurogenesis. Although half of the neurons born during neurod
Externí odkaz:
https://doaj.org/article/afbddd025bee472c8522a305ded18559
Autor:
María Pérez-Vázquez, Carla López-Causapé, Andrés Corral-Lugo, Michael J. McConnell, Jesús Oteo-Iglesias, Antonio Oliver, Antonio J. Martín-Galiano
Publikováno v:
Microorganisms, Vol 11, Iss 10, p 2486 (2023)
Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the pathogen Pseudomonas aeruginosa. Changes in their DNA binding regions, i.e., palindromic operators, can compromise pump depression and subsequently enhance
Externí odkaz:
https://doaj.org/article/f8211252f8564f5b8d3b80c57eeafdc5
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2023)
Acinetobacter baumannii is an important causative agent of hospital acquired infections. In addition to acquired resistance to many currently-available antibiotics, it is intrinsically resistant to fosfomycin. It has previously been shown that AmpD a
Externí odkaz:
https://doaj.org/article/c20a091c32684238bb7e9d3602e91cb3
Autor:
Ana Tajuelo, Octavio Carretero, Estéfani García-Ríos, Mireia López-Siles, Olga Cano, Mónica Vázquez, Vicente Más, Isabel Rodríguez-Goncer, Antonio Lalueza, Francisco López-Medrano, Rafael San Juan, Mario Fernández-Ruiz, José M. Aguado, Michael J. McConnell, Pilar Pérez-Romero
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/7d7ea77313b845db93f526c6bc7a8209
Autor:
Shiwei Liu, Adam C. Huckaby, Audrey C. Brown, Christopher C. Moore, Ian Burbulis, Michael J. McConnell, Jennifer L. Güler
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-23 (2021)
Abstract Single-cell genomics is a rapidly advancing field; however, most techniques are designed for mammalian cells. We present a single-cell sequencing pipeline for an intracellular parasite, Plasmodium falciparum, with a small genome of extreme b
Externí odkaz:
https://doaj.org/article/c0aa8fdcd77e47e2b462acb1a3425c1d
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Genetic alterations leading to the constitutive upregulation of specific efflux pumps contribute to antibacterial resistance in multidrug resistant bacteria. The identification of such resistance markers remains one of the most challenging tasks of g
Externí odkaz:
https://doaj.org/article/cb4cce786498402493d881d15f16bd6a