Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael J. Malecki"'
Publikováno v:
Journal of Health Economics and Outcomes Research, Vol 10, Iss 1 (2023)
**Background:** Breast cancer is the most common cancer among women in the United States. Newly diagnosed patients with breast cancer often experience anxiety, depression, and stress. However, the impact of psychological distress on healthcare resour
Externí odkaz:
https://doaj.org/article/3c36aff5ead4481c9925db8406e68f0f
Publikováno v:
Cancer Control, Vol 29 (2022)
Background Multimorbidity is common in patients with breast cancer, thus increasing the complexity of cancer care and economic burden, worsening their prognosis and quality of life. The prevalence of multimorbidity and its influence on psychological
Externí odkaz:
https://doaj.org/article/08b935edadf447d29daa8b53ebd82566
Publikováno v:
JCO Oncology Practice. 19:e660-e671
PURPOSE: Mental health comorbidities are commonplace among patients with cancer and have been associated with adverse health outcomes and elevated health care costs. Given the rapidly evolving cancer care landscape, an updated understanding of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df0b7cb774dd5582a5a686e2b2432cbe
https://doi.org/10.1200/op.22.00555
https://doi.org/10.1200/op.22.00555
Publikováno v:
Journal of the National Comprehensive Cancer Network. 20:HSR22-131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3addb5fe66dd5ef2b1b323d27a746d18
https://doi.org/10.6004/jnccn.2021.7251
https://doi.org/10.6004/jnccn.2021.7251
Autor:
Wendy R Gordon, Didem Vardar-Ulu, Sarah L'Heureux, Todd Ashworth, Michael J Malecki, Cheryll Sanchez-Irizarry, Debbie G McArthur, Gavin Histen, Jennifer L Mitchell, Jon C Aster, Stephen C Blacklow
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6613 (2009)
Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the re
Externí odkaz:
https://doaj.org/article/bd8fa4227a984c5fb57219385262de3b
Autor:
Cheryll Sanchez-Irizarry, Jon C. Aster, Gavin Histen, Mina L. Xu, Jennifer L. Mitchell, Stephen C. Blacklow, Michael J. Malecki
Publikováno v:
Molecular and Cellular Biology. 26:4642-4651
The NOTCH1 receptor is cleaved within its extracellular domain by furin during its maturation, yielding two subunits that are held together noncovalently by a juxtamembrane heterodimerization (HD) domain. Normal NOTCH1 signaling is initiated by the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9e97b264b069aed2a653d9f53bbb6f
https://doi.org/10.1128/mcb.01655-05
https://doi.org/10.1128/mcb.01655-05
Autor:
Michael J. Malecki, Sarah L'Heureux, Didem Vardar-Ulu, Jennifer L. Mitchell, Todd Ashworth, Wendy R. Gordon, Cheryll Sanchez-Irizarry, Stephen C. Blacklow, Debbie G. McArthur, Gavin Histen, Jon C. Aster
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6613 (2009)
PLoS ONE
PLoS ONE
Background Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38bb60944f313482ebab1c044c1809e
http://europepmc.org/articles/PMC2726630?pdf=render
http://europepmc.org/articles/PMC2726630?pdf=render
Autor:
Jon C. Aster, Woojoong Lee, Mina L. Xu, Cheryll Sanchez-Irizarry, Stephen C. Blacklow, Michael J. Malecki
Publikováno v:
Blood. 106:843-843
NOTCH1 is a type I transmembrane receptor that regulates T cell development via a signaling pathway that relies on regulated proteolysis. During its maturation, most NOTCH1 is cleaved at a position 70 amino acids external to the transmembrane domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::febdf3846127339e4609c3b7f5431c9e
https://doi.org/10.1182/blood.v106.11.843.843
https://doi.org/10.1182/blood.v106.11.843.843