Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michael J. Lew"'
Autor:
Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate
Publikováno v:
iScience, Vol 11, Iss , Pp 93-113 (2019)
Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two distinct ECD
Externí odkaz:
https://doaj.org/article/106ae93fb3814699bbd1551cc5a6f606
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTPeptide mapping with mass spectrometry (MS) is an important tool for protein characterization in the biopharmaceutical industry. Historically, peptide mapping monitors post-translational modifications (PTMs) of protein products and process in
Externí odkaz:
https://doaj.org/article/32a2c9c93bbb4533a85f6d28c175f3b6
Autor:
Daniel Scott, Ross A. D. Bathgate, Mohammed Akhter Hossain, Paul R. Gooley, Asuka Inoue, Bradley L. Hoare, Ashish Sethi, Shoni Bruell, Michael J. Lew
Publikováno v:
iScience, Vol 11, Iss, Pp 93-113 (2019)
iScience
iScience
Summary The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two distinct ECD s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cef3fdf1e94b1fb58f096ad72c5377
http://hdl.handle.net/10097/00128216
http://hdl.handle.net/10097/00128216
Autor:
Michael J, Lew
Publikováno v:
Handbook of experimental pharmacology. 257
This chapter demystifies P-values, hypothesis tests and significance tests and introduces the concepts of local evidence and global error rates. The local evidence is embodied in this data and concerns the hypotheses of interest for this experiment,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5cb77216979a80e03d27161d2efc8653
https://pubmed.ncbi.nlm.nih.gov/31897610
https://pubmed.ncbi.nlm.nih.gov/31897610
Autor:
Michael J. Lewis, MD, Torsten Malm, MD, PhD, Anna Hallbergson, MD, PhD, Jens Johansson Ramgren, MD, Petru Liuba, MD, PhD
Publikováno v:
JTCVS Open, Vol 15, Iss , Pp 424-432 (2023)
Objective: To evaluate the long-term performance of the patch materials we have used to augment the pulmonary arterial tree across a wide spectrum of diagnoses and anatomical locations. Methods: Retrospective, single-center review of 217 consecutive
Externí odkaz:
https://doaj.org/article/3cac2dba3f374a82a6f0578333decc49
Autor:
Michael J. Lew
Publikováno v:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine ISBN: 9783030336554
This chapter demystifies P-values, hypothesis tests and significance tests and introduces the concepts of local evidence and global error rates. The local evidence is embodied in this data and concerns the hypotheses of interest for this experiment,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0d04f5ef42f941c80e36dd380b1f031
https://doi.org/10.1007/164_2019_286
https://doi.org/10.1007/164_2019_286
Autor:
Shenna Y. Langenbach, Qianyu Chen, Christine R. Keenan, Alastair G. Stewart, Danica Prodanovic, Michael J. Lew, Meina Li
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(3)
Cortisol, a physiologic glucocorticoid (GC), is essential for growth and differentiation of the airway epithelium. Epithelial function influences inflammation in chronic respiratory diseases. Synthetic GCs, including inhaled corticosteroids, exert an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa305599288496b94c961ade59d80b6
https://pubmed.ncbi.nlm.nih.gov/29167235
https://pubmed.ncbi.nlm.nih.gov/29167235
Autor:
Daniel P. Poole, Nigel W. Bunnett, Peter McIntyre, Silvia Amadesi, Wolfgang Liedtke, William Darby, Fe C. Abogadie, Tina Marie Lieu, Nicholas A. Veldhuis, Michael J. Lew
Publikováno v:
Journal of Biological Chemistry. 288:5790-5802
G protein-coupled receptors of nociceptive neurons can sensitize transient receptor potential (TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated receptor 2 (PAR(2)), a receptor for inflammatory proteases, is a majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4eef25696a95e2d1a3bee7046d650e4
https://doi.org/10.1074/jbc.m112.438184
https://doi.org/10.1074/jbc.m112.438184
Autor:
Michael J. Lew
Publikováno v:
British Journal of Pharmacology. 166:1559-1567
Statistical analysis is universally used in the interpretation of the results of basic biomedical research, being expected by referees and readers alike. Its role in helping researchers to make reliable inference from their work and its contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f65f250594614ec80b6e5bf06dbe67
https://doi.org/10.1111/j.1476-5381.2012.01931.x
https://doi.org/10.1111/j.1476-5381.2012.01931.x
Autor:
Michael J. Lew, John Ludbrook
Publikováno v:
ANZ Journal of Surgery. 79:565-570
THE CLINICAL PROBLEM: If a surgeon has performed a particular operation on n consecutive patients without major complications, what is the long-term risk of major complications after performing many more such operations? Examples of such operations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80aaade3820c2a381d7a9040aa985835
https://doi.org/10.1111/j.1445-2197.2009.04994.x
https://doi.org/10.1111/j.1445-2197.2009.04994.x