Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Michael J. Kruhlak"'
Autor:
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and chro
Externí odkaz:
https://doaj.org/article/53398503c4ff4121a84866fffaede387
Autor:
Teresa Olbrich, Maria Vega-Sendino, Desiree Tillo, Wei Wu, Nicholas Zolnerowich, Raphael Pavani, Andy D. Tran, Catherine N. Domingo, Mariajose Franco, Marta Markiewicz-Potoczny, Gianluca Pegoraro, Peter C. FitzGerald, Michael J. Kruhlak, Eros Lazzerini-Denchi, Elphege P. Nora, André Nussenzweig, Sergio Ruiz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Embryos at the 2-cell (2C) stage are totipotent, and overexpression of Dux transcription factor convert embryonic stem cells (ESCs) to a 2C-like state. Here the authors show that DUX-mediated 2C-like reprogramming is associated with DNA damage at CTC
Externí odkaz:
https://doaj.org/article/bf8a1039f8ce4857979f039a7114f987
Autor:
Michael W. Caminear, Brittney S. Harrington, Rahul D. Kamdar, Michael J. Kruhlak, Christina M. Annunziata
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Epithelial ovarian cancer (EOC) is a global health burden and remains the fifth leading cause of cancer related death in women worldwide with the poorest five-year survival rate of the gynecological malignancies. EOC recurrence is considered to be dr
Externí odkaz:
https://doaj.org/article/14e1d4141a4547b7b2afe47a93cc6cab
Autor:
Raul Vizcardo, Nicholas D. Klemen, S.M. Rafiqul Islam, Devikala Gurusamy, Naritaka Tamaoki, Daisuke Yamada, Haruhiko Koseki, Benjamin L. Kidder, Zhiya Yu, Li Jia, Amanda N. Henning, Meghan L. Good, Marta Bosch-Marce, Takuya Maeda, Chengyu Liu, Zied Abdullaev, Svetlana Pack, Douglas C. Palmer, David F. Stroncek, Fumito Ito, Francis A. Flomerfelt, Michael J. Kruhlak, Nicholas P. Restifo
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3175-3190 (2018)
Summary: Induced pluripotent stem cell (iPSC)-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the OP9/DLL1 system, have shown abnormalities that pose major barriers for clinical transl
Externí odkaz:
https://doaj.org/article/720cb2131104496bbbc49192af4af5f1
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1703-1717 (2014)
Summary: The DNA damage response (DDR) occurs in the context of chromatin, and architectural features of chromatin have been implicated in DNA damage signaling and repair. Whereas a role of chromatin decondensation in the DDR is well established, we
Externí odkaz:
https://doaj.org/article/9b994eb07d2542ec980c6448db24d57d
Autor:
Simran Khurana, Michael J. Kruhlak, Jeongkyu Kim, Andy D. Tran, Jinping Liu, Katherine Nyswaner, Lei Shi, Parthav Jailwala, Myong-Hee Sung, Ofir Hakim, Philipp Oberdoerffer
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1049-1062 (2014)
Appropriate DNA double-strand break (DSB) repair factor choice is essential for ensuring accurate repair outcome and genomic integrity. The factors that regulate this process remain poorly understood. Here, we identify two repressive chromatin compon
Externí odkaz:
https://doaj.org/article/bcbd40e8c18048598eca34e3d1b5e693
Publikováno v:
Biochemical and Biophysical Research Communications. 663:171-178
Autor:
S.M. Rafiqul Islam, Takuya Maeda, Naritaka Tamaoki, Meghan L. Good, Rigel J. Kishton, Biman C. Paria, Zhiya Yu, Marta Bosch-Marce, Nicole M. Bedanova, Chengyu Liu, Michael J. Kruhlak, Nicholas P. Restifo, Raul Vizcardo
Publikováno v:
Cancer Research Communications. 3:917-932
Tumor-infiltrating lymphocytes (TIL) that can recognize and kill tumor cells have curative potential in subsets of patients treated with adoptive cell transfer (ACT). However, lack of TIL therapeutic efficacy in many patients may be due in large part
Autor:
Dongpeng Wang, Wei Wu, Elsa Callen, Raphael Pavani, Nicholas Zolnerowich, Srikanth Kodali, Dali Zong, Nancy Wong, Santiago Noriega, William J. Nathan, Gabriel Matos-Rodrigues, Raj Chari, Michael J. Kruhlak, Ferenc Livak, Michael Ward, Keith Caldecott, Bruno Di Stefano, André Nussenzweig
Publikováno v:
Science
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage specification—induced pluripotent stem cell–
Autor:
Raul Vizcardo, Nicholas P. Restifo, Michael J. Kruhlak, Chengyu Liu, Nicole M. Bedanova, Marta Bosch-Marce, Zhiya Yu, Biman C. Paria, Rigel J. Kishton, Meghan L. Good, Naritaka Tamaoki, Takuya Maeda, S.M. Rafiqul Islam
The list of antibodies used in the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9675074aa2457f197b048919763451
https://doi.org/10.1158/2767-9764.23185862.v1
https://doi.org/10.1158/2767-9764.23185862.v1