Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Michael J. Jackson"'
Autor:
Erika Coletto, Iain R. Tough, Sara Pritchard, Atsuko Hikima, Michael J. Jackson, Peter Jenner, K. Ray Chaudhuri, Helen M. Cox, Mahmoud M. Iravani, Sarah Rose
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical changes in the
Externí odkaz:
https://doaj.org/article/510bc52c596442c9b171cfd7f59f12c7
Publikováno v:
Future Internet, Vol 14, Iss 11, p 327 (2022)
Technological evolution and its potential impacts are of significant interest to governments, corporate organizations and for academic enquiry; but assessments of technology progression are often highly subjective. This paper prototypes potential obj
Externí odkaz:
https://doaj.org/article/27047a25850147f1a6f316ecb574d1f8
Publikováno v:
Journal of Rehabilitation Medicine, Vol 53, Iss 4, p jrm00184 (2021)
Objective: To evaluate and assess the effectiveness of muscle strengthening and cardiovascular interventions in improving outcomes in poliomyelitis (polio) survivors. Data sources: A systematic literature search was conducted in Medline, PubMed, CINA
Externí odkaz:
https://doaj.org/article/0b8f21b692954847ac7ce2a4284b5b63
Publikováno v:
Geochemistry, Geophysics, Geosystems, Vol 19, Iss 10, Pp 3811-3831 (2018)
Abstract Volcanic ash flow tuffs (ignimbrites) may contain single domain‐sized (titano) magnetite that should be good for recording geomagnetic field intensity, but due to their complex thermal histories also contain other magnetic grains, which ca
Externí odkaz:
https://doaj.org/article/78ee43c47efe44da8c9c2ae3ba1050b5
Publikováno v:
ISPRS International Journal of Geo-Information, Vol 8, Iss 1, p 34 (2019)
The topic of technology development and its disruptive effects has been the subject of much debate over the last 20 years with numerous theories at both macro and micro scales offering potential models of technology progression and disruption. This p
Externí odkaz:
https://doaj.org/article/2e536034af154e9fb6a1a36d5d488caf
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 3, Pp 599-607 (2010)
Hyperinnervation of the striatum by serotoninergic (5-HT) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. Recent studies have suggested that non-physiological release of dopamine (DA) formed from levodopa in these serot
Externí odkaz:
https://doaj.org/article/f8786945a012434bac24b956b33b62cc
Autor:
Didier G. Leibovici, Julian F. Rosser, Crona Hodges, Barry Evans, Michael J. Jackson, Chris I. Higgins
Publikováno v:
ISPRS International Journal of Geo-Information, Vol 6, Iss 3, p 78 (2017)
Volunteer geographical information (VGI), either in the context of citizen science or the mining of social media, has proven to be useful in various domains including natural hazards, health status, disease epidemics, and biological monitoring. Nonet
Externí odkaz:
https://doaj.org/article/a7b25fced9184c5b8dfa5d8921694a9e
Autor:
Michael J. Jackson, Atsuko Hikima, Erika Coletto, Helen M. Cox, Mahmoud M. Iravani, Sara Pritchard, Peter Jenner, Sarah Rose, Iain R. Tough, K. Ray Chaudhuri
Publikováno v:
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-11 (2021)
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-11 (2021)
The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical changes in the enteric
Autor:
Sarah Rose, Ria Fisher, Mark A. Varney, Ronan Depoortère, Atsuko Hikima, Rebecca Morris, Adrian Newman-Tancredi, Michael J. Jackson
Publikováno v:
Fisher, R, Hikima, A, Morris, R, Jackson, M J, Rose, S, Varney, M A, Depoortere, R & Newman-Tancredi, A 2020, ' The selective 5-HT 1A receptor agonist, NLX-112, exerts anti-dyskinetic and anti-parkinsonian-like effects in MPTP-treated marmosets ', Neuropharmacology, vol. 167, 107997 . https://doi.org/10.1016/j.neuropharm.2020.107997
King's College London
Neuropharmacology
King's College London
Neuropharmacology
l-DOPA is the gold-standard pharmacotherapy for treatment of Parkinson's disease (PD) but can lead to the appearance of troubling dyskinesia which are attributable to ‘false neurotransmitter’ release of dopamine by serotonergic neurons. Reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3085a626eb1b59f691bd663fbecf739e
https://kclpure.kcl.ac.uk/en/publications/1e11b8e0-d1b8-4575-878a-9a65a73748ba
https://kclpure.kcl.ac.uk/en/publications/1e11b8e0-d1b8-4575-878a-9a65a73748ba
Publikováno v:
King's College London
Mann, L, Jackson, M, Lincoln, L, Fisher, R, Rose, S & Duty, S 2020, ' Antiparkinsonian effects of a metabotropic glutamate receptor 4 agonist in MPTP-treated marmosets ', Journal of parkinsons disease .
Mann, L, Jackson, M, Lincoln, L, Fisher, R, Rose, S & Duty, S 2020, ' Antiparkinsonian effects of a metabotropic glutamate receptor 4 agonist in MPTP-treated marmosets ', Journal of parkinsons disease .
Background: Increased firing across glutamatergic synapses may contribute to both the motor dysfunction and L-DOPA-induced dyskinesia seen in Parkinson’s disease. Given their ability to reduce glutamate release, activation of group III metabotropic