Výsledky vyhledávání - "Michael J. Hoy"

Akademický článek

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans

Autor: Angela Rivera, Won Young Lim, Eunchong Park, Patrick A. Dome, Michael J. Hoy, Ivan Spasojevic, Sheng Sun, Anna Floyd Averette, Sergio Pina-Oviedo, Praveen R. Juvvadi, William J. Steinbach, Maria Ciofani, Jiyong Hong, Joseph Heitman

Publikováno v: mBio, Vol 14, Iss 5 (2023)

ABSTRACT Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizing

Externí odkaz: https://doaj.org/article/ce0b324bccb346759ee1b133f5211833

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Akademický článek

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

Autor: Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman

Publikováno v: mBio, Vol 13, Iss 3 (2022)

ABSTRACT Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the s

Externí odkaz: https://doaj.org/article/117f01418524456e8457bbd3d23cdecf

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Akademický článek

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)

FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm

Externí odkaz: https://doaj.org/article/4b8d65315776423982c1bea6612cead9

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Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity ExhibitIn VivoTherapeutic Efficacy against Cryptococcus

Publikováno v: mBio. 13

Due to rising rates of antifungal drug resistance and a limited armamentarium of antifungal treatments, there is a paramount need for novel antifungal drugs to treat systemic fungal infections. Calcineurin has been established as an essential and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89d5e3691f424b12df939e277bf0aabc
https://doi.org/10.1128/mbio.01049-22

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Akademický článek

Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans

Autor: Emma Watson, Viridiana Olin-Sandoval, Michael J Hoy, Chi-Hua Li, Timo Louisse, Victoria Yao, Akihiro Mori, Amy D Holdorf, Olga G Troyanskaya, Markus Ralser, Albertha JM Walhout

Publikováno v: eLife, Vol 5 (2016)

Metabolic network rewiring is the rerouting of metabolism through the use of alternate enzymes to adjust pathway flux and accomplish specific anabolic or catabolic objectives. Here, we report the first characterization of two parallel pathways for th

Externí odkaz: https://doaj.org/article/e41dab67960c492ea49983dc8cb5e514

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Fungal pathogens

Autor: Sheng Sun, Michael J. Hoy, Joseph Heitman

Publikováno v: Current biology : CB. 30(19)

Fungi are key components in global biogeochemical cycles, play important roles in manufacturing industries and biomedical research, and influence humans through their impact on global health, agriculture, and biodiversity. Fungi have been isolated fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3559964ad73a797ce6c23c20628aac1
https://pubmed.ncbi.nlm.nih.gov/33022261

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Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex

Autor: Anna F. Averette, Yong Sun Bahn, Kwang Woo Jung, Michael J. Hoy, Jeffrey I. Everitt, Kyung-Tae Lee, Joseph Heitman

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports

The unfolded protein response (UPR) pathway, consisting of the evolutionarily conserved Ire1 kinase/endonuclease and the bZIP transcription factor Hxl1, is critical for the pathogenicity of Cryptococcus neoformans; however, its role remains unknown i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7c89febb6fceea2ef9fee1c90ad23b
http://link.springer.com/article/10.1038/s41598-018-26405-5

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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications

Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e25dca73de3347142bc94a3eb686547
https://doi.org/10.1038/s41467-019-12199-1

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Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans

Autor: Timo Louisse, Markus Ralser, Akihiro Mori, Michael J. Hoy, Chi-Hua Li, Viridiana Olin-Sandoval, Emma Watson, Amy D. Holdorf, Albertha J.M. Walhout, Olga G. Troyanskaya, Victoria Yao

Publikováno v: eLife, Vol 5 (2016)
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66adbb8afea6be7b3910ff7876bd24cd
https://elifesciences.org/articles/17670

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