Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael J. Gumkowski"'
Autor:
Bruce C. MacDonald, Patrick Lukulay, Anthony J. Carella, Michael Christopher Roy, Michael J. Gumkowski, Sheri L. Shamblin, Kenneth Craig Waterman
Publikováno v:
Pharmaceutical Research. 24:780-790
To propose and test a new accelerated aging protocol for solid-state, small molecule pharmaceuticals which provides faster predictions for drug substance and drug product shelf-life. The concept of an isoconversion paradigm, where times in different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0370d331a1d64ffea37402460cb2ed
https://doi.org/10.1007/s11095-006-9201-4
https://doi.org/10.1007/s11095-006-9201-4
Publikováno v:
The Journal of Physical Chemistry. 94:8832-8835
Long-chain perfluorocarboxylates have been found to have stronger electronic absorption bands in the 205-225-nm region than perfluoroacetates. The absorptivity increases significantly on micelle formation in some regions. This increase can be used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f1a69acf41e9d29f887c5c4e17ea06
https://doi.org/10.1021/j100388a016
https://doi.org/10.1021/j100388a016
Autor:
Michael J. Gumkowski, Sharad B. Murdande, D. Freel, T.S. Shah, L.C. Erhart, J. Thornton-Manning, Michael Ellis Perlman, C.M. Rodricks
Publikováno v:
International journal of pharmaceutics. 351(1-2)
Torcetrapib is a highly lipophilic ( C log P = 7.45) and water insoluble cholesteryl ester transfer protein (CETP) inhibitor developed for the treatment of atherosclerosis. Self-emulsifying drug delivery system (SEDDS) formulations have been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ce1d9c537cbc25dd26172884eea600
https://pubmed.ncbi.nlm.nih.gov/18024021
https://pubmed.ncbi.nlm.nih.gov/18024021
Publikováno v:
ACS Symposium Series ISBN: 9780841233331
Surfactant Adsorption and Surface Solubilization
Surfactant Adsorption and Surface Solubilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdcb5ccc89d2d97aedd348c31ff5df87
https://doi.org/10.1021/bk-1995-0615.ch002
https://doi.org/10.1021/bk-1995-0615.ch002
Autor:
Richard M. Shepard, Gregory M. Hockel, Bruce Allen Lefker, Michael L. Mangiapane, Michael J. Gumkowski, Ward H. Smith, Jasjit S. Bindra, M. J. Gardner, Robert L. Rosati, Mark R. Nocerini, William F. Holt, Wester Ronald Thure, Dennis J. Hoover, Kleinman Edward F, William R. Murphy, Ian H. Williams
Publikováno v:
Aspartic Proteinases ISBN: 9781461357612
Oral bioavailability has been a formidable barrier to the development of drugs which mimic the structures of biologically active peptides. This report describes the discovery of potent renin inhibitors having high oral bioavailability and good plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28e9ffb8993c016e2a25ca68d3790d5
https://doi.org/10.1007/978-1-4615-1871-6_21
https://doi.org/10.1007/978-1-4615-1871-6_21
Autor:
RAVI SHARMA, Pasupati Mukerjee, Richard A. Pyter, Michael J. Gumkowski, C. Treiner, V. Monticone, John H. O'Haver, Jeffrey H. Harwell, Chung-Ching Yu, Lance L. Lobban, Luuk K. Koopal, Tanya Goloub, P. Somasundaran, S. Krishnakumar, Joy T. Kunjappu, Kunio Esumi, Martin G. Bakker, Dexter D. Murphy, Brandon Davis, Paul F. Luckham, A. I. Bailey, F. Miano, T. F. Tadros, M. M. Santore, M. S. Kelly, E. Mubarekyan, V. A. Rebar, T. Cosgrove, S. J. Mears, L. Thompson, I. Howell, J. F. Bishop, T. H. Mourey, J. Texter, Shaun H. Chen, Curtis W. Frank, Fredrik Tiberg, Johanna Brinck, L. Huang, C. Maltesh, Simon Biggs, Paul Mulvaney, Patrick J. Breen, Christopher J. Rulison, Robert Y. Lochhead, L. J. Fina, J. R. Lu, R. K. Thomas, Atul N. Parikh, Jonathan Wood, David L. Allara, D. T. Smith, D. Y. Kwok, P. Chiefalo, B. Khorshiddoust, S. Lahooti, M. A. Cabrerizo-Vilchez, O. del Rio, A. W. Neumann
Autor:
Rakesh Kumar Tekade
Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future.