Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Michael J. Greig"'
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
Rapid mutations of proteins that are targeted in cancer therapy often lead to drug resistance. Often, the mutation directly affects a drug’s binding site, effectively blocking binding of the drug, but these mutations can have other effects such as
Externí odkaz:
https://doaj.org/article/4cdd757837e142f3bc96408a4ac0c80a
Autor:
Kevin K.-C. Liu, Jiangli Yan, Alexei Brooun, Michael J. Greig, H. Jane Dyson, Robert A. Love, Ya Li Deng, Rosa Cardoso, Jing Zhu, Simon Bergqvist, Ping Chen, Carol L. Nilsson, Nowlin Dawn Marie
Publikováno v:
Protein Science. 21:1885-1896
The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small
Autor:
Stone D.-H. Shi, Roslyn Dillon, Bryan Krastins, Nathan V. Lee, Michael J. Greig, Carol L. Nilsson
Publikováno v:
Journal of Proteome Research. 10:5084-5094
In recent years, there have been notable advances with the development of anticancer drugs including those targeting protein tyrosine kinases such as the c-Met receptor, which has been implicated in the development and progression of several cancers.
Autor:
Joseph Wu, Michael J. Greig, Wade Diehl, Alan G. Marshall, Xiu Yu, Hui-Min Zhang, Mark R. Emmett, Ketan S. Gajiwala, Elizabeth A. Lunney
Publikováno v:
Protein Science. 19:703-715
Mutations of the receptor tyrosine kinase KIT are linked to certain cancers such as gastrointestinal stromal tumors (GISTs). Biophysical, biochemical, and structural studies have provided insight into the molecular basis of resistance to the KIT inhi
Autor:
Bryan Krastins, Michael Major, Yongjie Ji, Frederick F. Lang, John C. Rogers, Arugadoss Devakumar, Mary F. Lopez, Howard Colman, Carol L. Nilsson, Michael Rosenblatt, Barbara Kaboord, Waldemar Priebe, Gregory Kilmer, Charles A. Conrad, Michael J. Greig, Taha Rezai, Stone D.-H. Shi, David A. Sarracino, Roslyn Dillon, Amol Prakash
Publikováno v:
Journal of Proteome Research. 9:430-443
Initiation and maintenance of several cancers including glioblastoma (GBM) may be driven by a small subset of cells called cancer stem cells (CSCs). CSCs may provide a repository of cells in tumor cell populations that are refractory to chemotherapeu
Autor:
Sherry Niessen, Michael J. Greig, Jun Li Feng, Manli Shi, Scott L. Weinrich, Theodore O. Johnson
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
International Journal of Cell Biology
International Journal of Cell Biology
Rapid mutations of proteins that are targeted in cancer therapy often lead to drug resistance. Often, the mutation directly affects a drug’s binding site, effectively blocking binding of the drug, but these mutations can have other effects such as
Publikováno v:
Journal of Chromatography B. 825:176-185
Liquid chromatography-mass spectrometry (LC-MS) has been used extensively in determination of the molecular weights of proteins, as well as covalent protein-ligand complexes. We have successfully developed LC-MS method for protein molecular weight me
Autor:
Haitao Li, Doug Phillipson, Ben Bolaños, Catherine Pham, William Farrell, Christine Aurigemma, Jessica M. R. Bylund, Kathleen Tivel, Michael J. Greig, Terri Quenzer, Phuong Tran, Manuel Ventura
Publikováno v:
International Journal of Mass Spectrometry. 238:85-97
We report the use of supercritical fluid chromatography/mass spectrometry (SFC/MS) for numerous applications in drug discovery at Pfizer, La Jolla. Namely, SFC/MS has been heavily relied upon for analysis and purification of a diverse set of compound
Autor:
Ola Blixt, Valery V. Fokin, James C. Paulson, Manuel Ventura, Michael J. Greig, Gary Siuzdak, John E. Crowell, Zhouxin Shen, Raymond C. Stevens, Eden P. Go, Alejandra Gámez, M. G. Finn, Junefredo V. Apon
Publikováno v:
ChemBioChem. 5:921-927
A surface-based laser desorption/ionization mass spectrometry assay that makes use of Desorption/Ionization on Silicon Mass Spectrometry (DIOS-MS) has been developed to monitor enzyme activity and enzyme inhibition. DIOS-MS has been used to character
Publikováno v:
Rapid Communications in Mass Spectrometry. 17:2763-2768
Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) was coupled with atmospheric pressure photoionization (APPI) for the first time and used for the analysis of several corticosteroids.1 The analytes showed excellent response using