Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Michael J. Gait"'
Autor:
Dhanu Gupta, Sara Orehek, Janne Turunen, Liz O’Donovan, Michael J. Gait, Samir El-Andaloussi, Matthew J. A. Wood
Publikováno v:
Cells, Vol 12, Iss 18, p 2285 (2023)
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in maintaining normal homeostatic processes under the pathogenesis of various inflammatory and autoimmune diseases. This context-dependent effect from a cytokine is due to two d
Externí odkaz:
https://doaj.org/article/5a318b60e70e48a49a8ececc4099cc3d
Autor:
Suzan M. Hammond, Frank Abendroth, Larissa Goli, Jessica Stoodley, Matthew Burrell, George Thom, Ian Gurrell, Nina Ahlskog, Michael J. Gait, Matthew J.A. Wood, Carl I. Webster
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new genetic drug modalities. However, their high molecular weight limits their bioavailability for otherwise-treatable neurological disorders. We investigated conjugation of
Externí odkaz:
https://doaj.org/article/e10b5264221549b9be42dfc52acf597f
Autor:
Julien Tailhades, Hotake Takizawa, Michael J. Gait, Don A. Wellings, John D. Wade, Yoshitsugu Aoki, Fazel Shabanpoor
Publikováno v:
Frontiers in Chemistry, Vol 5 (2017)
Antisense oligonucleotide (ASO)-based drug development is gaining significant momentum following the recent FDA approval of Eteplirsen (an ASO based on phosphorodiamidate morpholino) and Spinraza (2′-O-methoxyethyl-phosphorothioate) in late 2016. T
Externí odkaz:
https://doaj.org/article/3d3daccb5568402a9e5ed87d1c5de9f4
The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended,
Autor:
Jonathan K. Watts, Michael J. Gait
Publikováno v:
Nucleic Acids in Chemistry and Biology ISBN: 9781788019040
Nucleic acid syntheses in a wide variety of forms are required for multiple research activities: in nucleic acids chemistry, chemical biology, molecular biology, synthetic biology, genetics and precision therapeutics. For the chemical synthesis of mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f85025d89b014446bda42882eae3768c
https://doi.org/10.1039/9781837671328-00279
https://doi.org/10.1039/9781837671328-00279
Publikováno v:
Nucleic Acids in Chemistry and Biology ISBN: 9781788019040
For over 60 years, we have been fascinated and stimulated by their awareness that the study of nucleic acids is central to the knowledge of life. This chapter looks at the biological importance of DNA, the origins of nucleic acids research, early str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5386a15a3211d01178a7caa2edfbc186
https://doi.org/10.1039/9781837671328-00001
https://doi.org/10.1039/9781837671328-00001
Autor:
Michael J, Gait, Sudhir, Agrawal
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2434
This introduction charts the history of the development of the major chemical modifications that have influenced the development of nucleic acids therapeutics focusing in particular on antisense oligonucleotide analogues carrying modifications in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e7c8cb715d128e3d288de259e6ad800
https://pubmed.ncbi.nlm.nih.gov/35213007
https://pubmed.ncbi.nlm.nih.gov/35213007
Autor:
Wooi F. Lim, Melissa Bowerman, Corinne A. Betts, Lara Cravo, Aarti Jagannath, Tirsa L.E. van Westering, Jinhong Meng, Katarzyna Chwalenia, Russell G. Foster, Jennifer E. Morgan, Carlo Rinaldi, Maria Sofia Falzarano, Elizabeth O’Donovan, Alessandra Ferlini, Graham McClorey, Katharina E. Meijboom, John R. Counsell, Amarjit Bhomra, Matthew J.A. Wood, Michael J. Gait, Amer F. Saleh, Subhashis Banerjee
Publikováno v:
Life Science Alliance
Absence of integral sarcolemmal protein, dystrophin, disrupts the RhoA-actin-SRF cascade in skeletal muscle, with subsequent dysregulation of downstream-SRF circadian targets and circadian rhythm.
Absence of dystrophin, an essential sarcolemmal
Absence of dystrophin, an essential sarcolemmal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d711e18ebfc93027b1f5621297a5949
https://doi.org/10.26508/lsa.202101014
https://doi.org/10.26508/lsa.202101014
Autor:
Larissa Goli, Ian Gurrell, Matthew Burrell, Matthew J.A. Wood, Nina Ahlskog, Suzan M. Hammond, George Thom, Michael J. Gait, Carl I. Webster, Jessica Stoodley, Frank Abendroth
Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new genetic drug modalities, however, the high molecular weight limits their bioavailability for otherwise treatable neurological disorders. We investigated conjugation of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab1b1dbae12385c5470237071678d2a3
https://doi.org/10.1101/2021.07.29.454272
https://doi.org/10.1101/2021.07.29.454272
Autor:
Michael J. Gait
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 66:79-100
Dan Brown was a nucleic acids chemist of the highest order, beginning with pioneering work under Lord Alexander Todd in the 1950s at University of Cambridge on chemical methods for synthesis of nucleosides and nucleotides. This work helped to confirm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7706f7b196e386a28b5f25b18372b111
https://doi.org/10.1098/rsbm.2018.0008
https://doi.org/10.1098/rsbm.2018.0008