Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael J. G. Milevskiy"'
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells
Autor:
Choon Leng So, Mélanie Robitaille, Francisco Sadras, Michael H. McCullough, Michael J. G. Milevskiy, Geoffrey J. Goodhill, Sarah J. Roberts-Thomson, Gregory R. Monteith
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Differences in shape can be a distinguishing feature between different cell types, but the shape of a cell can also be dynamic. Changes in cell shape are critical when cancer cells escape from the primary tumor and undergo major morphologica
Externí odkaz:
https://doaj.org/article/d73be88b33ce498590a3f9946c02f12e
Autor:
Jaynish S. Shah, Michael J. G. Milevskiy, Veronika Petrova, Amy Y. M. Au, Justin J. L. Wong, Jane E. Visvader, Ulf Schmitz, John E. J. Rasko
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background After many years of neglect in the field of alternative splicing, the importance of intron retention (IR) in cancer has come into focus following landmark discoveries of aberrant IR patterns in cancer. Many solid and liquid tumour
Externí odkaz:
https://doaj.org/article/683ffd8de71f4bcaa4fcd67ff3102fbf
Autor:
Luuk Heitink, James R. Whittle, François Vaillant, Bianca D. Capaldo, Johanna F. Dekkers, Caleb A. Dawson, Michael J. G. Milevskiy, Elliot Surgenor, Minhsuang Tsai, Huei‐Rong Chen, Michael Christie, Yunshun Chen, Gordon K. Smyth, Marco J. Herold, Andreas Strasser, Geoffrey J. Lindeman, Jane E. Visvader
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1119-1131 (2022)
Breast cancer is a heterogeneous disease that comprises multiple histological and molecular subtypes. To gain insight into mutations that drive breast tumorigenesis, we describe a pipeline for the identification and validation of tumor suppressor gen
Externí odkaz:
https://doaj.org/article/a2c6e54222254a7aaa2607785b7929bf
Autor:
Bhupinder Pal, Yunshun Chen, Michael J. G. Milevskiy, François Vaillant, Lexie Prokopuk, Caleb A. Dawson, Bianca D. Capaldo, Xiaoyu Song, Felicity Jackling, Paul Timpson, Geoffrey J. Lindeman, Gordon K. Smyth, Jane E. Visvader
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-19 (2021)
Abstract Background Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling. To further understand how cellular diversity changes during mammary ontogeny, we profi
Externí odkaz:
https://doaj.org/article/d1cc3b8d744843f492534dc6e9d31a94
Autor:
Alice H. L. Bong, Mélanie Robitaille, Michael J. G. Milevskiy, Sarah J. Roberts‐Thomson, Gregory R. Monteith
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 87-104 (2020)
Neuronal calcium sensor‐1 (NCS‐1) is a positive modulator of IP3 receptors and was recently associated with poorer survival in breast cancers. However, the association between NCS‐1 and breast cancer molecular subtypes and the effects of NCS‐
Externí odkaz:
https://doaj.org/article/358fcc2c34d143f0ac5e3537c968f710
Autor:
Iman Azimi, Mélanie Robitaille, Kaela Armitage, Choon Leng So, Michael J. G. Milevskiy, Korinne Northwood, Huai Fang Lim, Erik W. Thompson, Sarah J. Roberts-Thomson, Gregory R. Monteith
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9417 (2020)
Epithelial to mesenchymal transition (EMT) in cancer is important in therapeutic resistance and invasiveness. Calcium signaling is key to the induction of EMT in breast cancer cells. Although inhibition of specific calcium-permeable ion channels regu
Externí odkaz:
https://doaj.org/article/f76322cb5dd84b2985ee817b3544c7b4
Publikováno v:
Laboratory Investigation. 100:199-206
Transient receptor potential cation channel subfamily V (TRPV) channels play important roles in a variety of cellular processes. One example includes the sensory role of TRPV1 that is sensitive to elevated temperatures and acidic environments and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b099d5c165d5c6532a6e03f353ef2c4
https://doi.org/10.1038/s41374-019-0348-0
https://doi.org/10.1038/s41374-019-0348-0
Autor:
Karen Doggett, Kimberly J Morgan, Stephen Mieruszynski, Benjamin B Williams, Anouk M Olthof, Alexandra L Garnham, Michael J G Milevskiy, Lachlan Whitehead, Janine Coates, Michael Buchert, Robert JJ O’Donoghue, Thomas E Hall, Zhiyuan Gong, Tracy L Putoczki, Matthias Ernst, Kate D Sutherland, Rahul N Kanadia, Joan K Heath
Minor splicing is a second splicing system required for the correct expression of ∼700 human minor intron-containing genes (MIGs). Many MIGs are expressed in vigorously proliferating cells and are frequently dysregulated in cancer including BRAF, E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a185529838d2cf3e4ee87696e8999421
https://doi.org/10.1101/2021.12.09.469623
https://doi.org/10.1101/2021.12.09.469623
Autor:
Jane E. Visvader, Felicity C. Jackling, Gordon K. Smyth, Geoffrey J. Lindeman, Paul Timpson, Yunshun Chen, Caleb A. Dawson, Lexie Prokopuk, François Vaillant, Bianca D. Capaldo, Bhupinder Pal, Xiaoyu Song, Michael J. G. Milevskiy
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-19 (2021)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling. To further understand how cellular diversity changes during mammary ontogeny, we profiled singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8092e8bcc8270f8b471c2cb28be3ef
https://doi.org/10.1186/s13058-021-01445-4
https://doi.org/10.1186/s13058-021-01445-4
Autor:
Mélanie Robitaille, Alice H.L. Bong, Gregory R. Monteith, Michael J. G. Milevskiy, Sarah J. Roberts-Thomson
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 87-104 (2020)
Molecular Oncology
Molecular Oncology
Neuronal calcium sensor‐1 (NCS‐1) is a positive modulator of IP3 receptors and was recently associated with poorer survival in breast cancers. However, the association between NCS‐1 and breast cancer molecular subtypes and the effects of NCS‐
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878917c0cbf918d9fa91d63507290cbb
https://doi.org/10.1002/1878-0261.12589
https://doi.org/10.1002/1878-0261.12589