Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Michael J. Fuller"'
Autor:
Beatriz León, Michael J. Fuller, Amber M. Papillion, Alejandro V. Villarino, Amy S. Weinmann, John J. O'Shea, Danielle A. Chisolm, André Ballesteros-Tato, Michael D. Powell, Kenneth J. Oestreich, Holly Bachus
Publikováno v:
Science immunology. 4(39)
Sustained TCR stimulation is required for maintaining germinal center T follicular helper cells (GC-T(FH)). Paradoxically, TCR activation induces interleukin-2 receptor (IL-2R) expression and IL-2 production, thereby initiating a feedback loop of IL-
Autor:
André Ballesteros-Tato, John E. Bradley, Holly Bachus, Amy S. Weinmann, Davide Botta, Troy D. Randall, Beatriz León, Michael J. Fuller, Tatiana T. Marquez-Lago, Frances E. Lund, Allan J. Zajac
Publikováno v:
Nature immunology. 18(11)
Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg
Autor:
Dana L. Hasselschwert, Arlene H. Sharpe, William C. Satterfield, Arash Grakoui, Benoit Callendret, Charles M. Rice, Michael J. Fuller, Lynn B. Dustin, Baogong Zhu, Rafi Ahmed, Christopher M. Walker, Gordon J. Freeman
Publikováno v:
Proceedings of the National Academy of Sciences. 110:15001-15006
Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling improves in vitro proliferation of HCV-specific T lymphocytes, but whethe
Autor:
Dana L. Hasselschwert, Arash Grakoui, Nilufer P. Seth, Naglaa H. Shoukry, David G. Bowen, Kathleen M. Brasky, Michael Houghton, Kai W. Wucherpfennig, Christopher M. Walker, Andrew G. Cawthon, Christine Dong, Gordon J. Freeman, Michael J. Fuller
Publikováno v:
Journal of Virology. 82:5109-5114
The inhibitory receptor programmed death-1 (PD-1) is present on CD8 + T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absen
Publikováno v:
Chemical Physics. 319:226-234
Ultrafast photoinduced charge separation in the donor–acceptor dyad, N-(10-phenyl-10-H-phenothiazine)-9-cyano-1,6-bis(3,5-di-tert-butylphenoxy)-perylene-3,4-dicarboximide (CNPMI-PTZ) occurs readily in both toluene and benzonitrile. When CNPMI-PTZ i
Autor:
Xiyou Li, Jovan M. Giaimo, Michael R. Wasielewski, Michael J. Fuller, Louise E. Sinks, Boris Rybtchinski
Publikováno v:
The Journal of Physical Chemistry A. 109:970-975
Condensation of 3,4,5-tris(n-dodecyloxy)aniline with the green chromophore 1,7-bis(N-pyrrolidinyl)perylene-3,4;9,10-tetracarboxylic dianhydride yields N,N'-bis(3,4,5-tris(n-dodecyloxy)phenyl)-1,7-bis(N-pyrrolidinyl)perylene-3,4;9,10-bis(dicarboximide
Publikováno v:
Israel Journal of Chemistry. 44:101-108
Photoexcitation of chromophoric dimers constrained to a symmetric π-stacked geometry by their molecular structure usually produce excimers independent of solvent polarity, while dimers with edge-to-edge perpendicular π systems undergo excited-state
Publikováno v:
The Journal of Immunology. 172:2834-2844
We have investigated the contribution of CD4 T cells to the optimal priming of functionally robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice with lymphocytic choriomeningitis virus resulted in the elabo
Autor:
Albert Tousson, Casey T. Weaver, Takekazu Kubo, Arman Saparov, Benjamin T. Weaver, James R. Oliver, Vincent Hurez, Michael J. Fuller
Publikováno v:
The Journal of Experimental Medicine
Limited frequencies of T cells express IL-2 in primary antigenic responses, despite activation marker expression and proliferation by most clonal members. To define the basis for restricted IL-2 expression, a videomicroscopic system and IL-2 reporter
Autor:
Allan J. Zajac, Michael J. Fuller
Publikováno v:
The Journal of Immunology. 170:477-486
To evaluate the impact of sustained viral loads on anti-viral T cell responses we compared responses that cleared acute lymphocytic choriomeningitis virus infection with those that were elicited but could not resolve chronic infection. During acute i