Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Michael J. Durcan"'
Publikováno v:
Pharmaceutical Research
Purpose To investigate the hypothesis that paracetamol is absorbed faster from a hot drink than from a standard tablet using simultaneous scintigraphic imaging and pharmacokinetic sampling. Methods Twenty-five healthy male volunteers received both pa
Autor:
Paul M. Matthews, Christopher J. Long, David M. Cole, Christian F. Beckmann, Michael J. Durcan, John D. Beaver
Publikováno v:
NeuroImage. 52:590-599
Symptoms of cognitive impairment during smoking withdrawal can be ameliorated by nicotine replacement. To define brain mechanisms contributing to this therapeutic effect, we conducted a functional connectivity analysis of resting-state fMRI in 17 abs
Autor:
Mitchell L. Kotler, Angela M. DeVeaugh-Geiss, Lisa R. Ramsay, Lilan H. Chen, Michael J. Durcan
Publikováno v:
Clinical Therapeutics. 32:1140-1148
A comparison of the 21-mg NiQuitin patch with other marketed nicotine patches reported significant differences in pharmacokinetic profiles, even among patches of the identical labeled dose strength. The 25-mg Nicorette Invisi patch became available i
Publikováno v:
Journal of Clinical Psychopharmacology. 28:667-674
Objective: Controversy exists over the effect of tobacco deprivation in nicotine-dependent individuals and the efficacy of nicotine in reversing performance decrements. This study's aim was to assess the efficacy of nicotine (4-mg lozenge) versus pla
Autor:
Troy D. Wolter, Richard D. Hurt, Kenneth P. Offord, David P.L. Sachs, J. Taylor Hays, Raymond Niaura, Michael J. Durcan, Nancy A. Rigotti, David Gonzales, J. Andrew Johnston
Publikováno v:
Addictive Behaviors. 27:493-507
The aim of this study was to identify predictors of successful relapse prevention in smokers receiving long-term sustained-release bupropion. Smokers (N=784) who were interested in stopping smoking were enrolled in a 7-week, open-label bupropion phas
Autor:
Douglas E. Jorenby, Scott J. Leischow, John A. Ascher, Stephen I. Rennard, Michael C. Fiore, Jonathan White, Mitchell A. Nides, J. Andrew Johnston, Michael J. Durcan
Publikováno v:
American Journal of Health Behavior. 26:213-220
Objective To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR). Methods Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers
Autor:
Nancy A. Rigotti, David Gonzales, Wendy Bjornson, J. Andrew Johnston, Richard D. Hurt, Raymond Niaura, Jonathan White, A. Sonia Buist, Michael J. Durcan, J. Taylor Hays, David P.L. Sachs
Publikováno v:
American Journal of Preventive Medicine. 22:234-239
Background: Recent data suggest that women smokers respond differently than men to cessation pharmacotherapies, particularly nicotine replacement therapy (NRT). Lower abstinence and higher relapse rates are often reported for women treated with NRT.
Autor:
Michael J. Durcan, Raymond Niaura, David P.L. Sachs, Nancy A. Rigotti, David Gonzales, J. Andrew Johnston, Greg Deener, Jonathan White
Publikováno v:
Clinical Therapeutics. 24:540-551
Most (50%) smokers who attempt to stop smoking relapse within the first year of abstinence. The effect of continued use of pharmacotherapy for smoking cessation on relapse rates is unknown. Bupropion sustained-release (SR) is the first non-nicotine-b
Autor:
Dipak K. Patel, Beth Bentley, Virginia D. Schmith, John A. Ascher, Robert Leadbetter, Michael J. Durcan, J. Andrew Johnston
Publikováno v:
Drugs. 62:11-24
Sustained-release bupropion (bupropion SR) is a unique, non-nicotine smoking cessation aid that is hypothesised to act upon neurological pathways involved in nicotine dependence. Pharmacokinetic and metabolism studies reveal that bupropion SR is meta
Publikováno v:
Life Sciences. 57:PL275-PL283
Binding of 3H-spiperone and 3H-raclopride to membranes of cells stably-transfected with a human dopamine D2 receptor clone was investigated, as was that of 3H-spiperone to those stably-transfected with a human D4 receptor clone. 3H-spiperone and 3H-r