Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael J. Donio"'
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Table S2 is a summary of AO-176 tumor cell killing in solid and hematologic tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c82520fd1d3690cfbf57b84b579fa69
https://doi.org/10.1158/1535-7163.22519501
https://doi.org/10.1158/1535-7163.22519501
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Table S1 shows the affinity and kinetics of AO-176 and AO-104 to human and cynomolgus monkey CD47 determined by surface plasmon resonance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ff9bd00db04ab5b6a1520ba10d79b2
https://doi.org/10.1158/1535-7163.22519504
https://doi.org/10.1158/1535-7163.22519504
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Figure S2 shows that AO-176 does not bind to mouse CD47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b05a9f14c962f64bc83eb6a37c819d0
https://doi.org/10.1158/1535-7163.22519516
https://doi.org/10.1158/1535-7163.22519516
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Figure S5 demonstrates that AO-176 does not mediate antibody dependent cell cytotoxicity of tumor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d37f05fc5401e3ca591b2d14f1a4e60
https://doi.org/10.1158/1535-7163.22519507.v1
https://doi.org/10.1158/1535-7163.22519507.v1
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Table S3 is a summary of AO-176 mediated phagocytosis of solid and hematologic tumor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8e50a90ac8a9c46d46772ee6296d50
https://doi.org/10.1158/1535-7163.22519498.v1
https://doi.org/10.1158/1535-7163.22519498.v1
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Figure S3 shows the specificity of AO-176 for human CD47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2817f064eff88eb6043109365c7022fb
https://doi.org/10.1158/1535-7163.22519513.v1
https://doi.org/10.1158/1535-7163.22519513.v1
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Figure S1 depicts the sequence and analytical characteristics of AO-176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fc642b44cc405b264bc62daf927fc1
https://doi.org/10.1158/1535-7163.22519519
https://doi.org/10.1158/1535-7163.22519519
Autor:
Daniel S. Pereira, Robert W. Karr, William A. Frazier, Pamela T. Manning, Michael J. Donio, Benjamin J. Capoccia, Ronald R. Hiebsch, Myriam N. Bouchlaka, Robyn J. Puro
Figure S4 demonstrates the minimal reduction in RBC and hemoglobin levels in cynomolgus monkeys treated with AO-176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103aa2ae70d6f06cdd0bc05e7bf6620a
https://doi.org/10.1158/1535-7163.22519510.v1
https://doi.org/10.1158/1535-7163.22519510.v1
Autor:
Pamela T. Manning, Ronald R. Hiebsch, Daniel S. Pereira, Benjamin J. Capoccia, Robyn J Puro, Michael J. Donio, Myriam N. Bouchlaka, William A. Frazier, Karr Robert W
Publikováno v:
Molecular Cancer Therapeutics. 19:835-846
Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47 is an innate immune checkpoint receptor broadly expressed on normal tissues and overexpressed on many tumors. Binding of tumor CD47 to signal regulatory protein a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167f2f437f2edfd0f87056982e7ae191
https://doi.org/10.1158/1535-7163.mct-19-1079
https://doi.org/10.1158/1535-7163.mct-19-1079
Autor:
Ronald R. Hiebsch, Robyn J Puro, Casey Wilson, Rachel Delston, Daniel S. Pereira, Arun K. Kashyap, Benjamin J. Capoccia, Michael J. Donio, Gabriela Andrejeva
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCD47 is a cell surface protein expressed on tumors that binds SIRPα on macrophages and dendritic cells resulting in a ”don’t eat me” signal that allows tumors to evade phagocytosis. The highly differentiated monoclonal antibody, AO-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee292c6258da9bb2fc86fcd25d2fc1e
https://doaj.org/article/5ea9add8ab9d4c4297ee134cebe5d2b2
https://doaj.org/article/5ea9add8ab9d4c4297ee134cebe5d2b2