Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michael J. Di Maso"'
Autor:
Christopher K. Prier, Karla Camacho Soto, Jacob H. Forstater, Nadine Kuhl, Jeffrey T. Kuethe, Wai Ling Cheung-Lee, Michael J. Di Maso, Claire M. Eberle, Shane T. Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin M. Maloney, Amanda Makarewicz, Jonathan P. McMullen, Jeffrey C. Moore, Grant S. Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David A. Thaisrivongs, Deeptak Verma, Adeya Wyatt, Daniel Zewge
Publikováno v:
ACS Catalysis. :7707-7714
Enzymes are capable of unique and selective transformations that can enable sustainable chemical production. While many industrial processes have been developed using free enzymes in aqueous solutions, immobilizing enzymes on a solid support can offe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90db8b74a305bd69c240df125bc8b9b
https://doi.org/10.1021/acscatal.3c00941
https://doi.org/10.1021/acscatal.3c00941
Autor:
Rebecca A. Arvary, Michael J. Di Maso, Darryl Chang, Sachin Lohani, Francisco J. Guzman, Lisa Jellett, Ralph Zhao, Hong Ren, Michael A. Zompa, Siqing Song
Publikováno v:
Organic Process Research & Development. 25:1937-1942
The manufacturing route toward gefapixant citrate generates a trace amount of cyanide as a byproduct of a reaction employing the reagent chloroacetonitrile. In the development of a cyanide control ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7172ebda87e07734b28fe7c5ad11a539
https://doi.org/10.1021/acs.oprd.1c00185
https://doi.org/10.1021/acs.oprd.1c00185
Autor:
Noah P. Burlow, Jason E. Hein, Darlene Q. Tan, Kristin Shimabukuro, Thomas C. Malig, James C. Fettinger, Michael J. Di Maso, Sara Y. Howard, Jared T. Shaw
Publikováno v:
The Journal of Organic Chemistry. 86:11599-11607
The mechanisms for the three- and four-component variants of the Castagnoli-Cushman reaction (CCR) have been investigated. A series of crossover experiments were conducted to probe the structure and reactivity of known amide-acid intermediates for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5123266477f8a56eaf81a3f98a844c
https://doi.org/10.1021/acs.joc.1c01163
https://doi.org/10.1021/acs.joc.1c01163
Publikováno v:
Organic Process Research & Development. 24:2935-2940
A simple and inexpensive photoreactor with a throughput of kilograms of material per day has been developed. This achievement was enabled by using high-power Light Emitting Diodes (LEDs) to provide...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedadb6c415b213d3b5eddca4e95638c
https://doi.org/10.1021/acs.oprd.0c00373
https://doi.org/10.1021/acs.oprd.0c00373
Autor:
Anne E. Mohan, Siqing Song, Hsieh Yao D. Chang, Si-Wei Zhang, Patrick Larpent, Wenjun Liu, Michael DiBenedetto, Eric B. Sirota, Michael J. Di Maso, Richard Desmond, Kevin M. Maloney, Ivan H. Lee, Alfred Y. Lee, Guy R. Humphrey, Embarek Alwedi, Hong Ren
Publikováno v:
Organic Process Research & Development. 24:2498-2504
The development of a sustainable commercial salt formation process for gefapixant citrate (MK-7264), an investigational new P2X3 antagonist for the treatment of chronic cough, is described. Due to ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facd961a62dfed3fd28d482411a9320b
https://doi.org/10.1021/acs.oprd.0c00260
https://doi.org/10.1021/acs.oprd.0c00260
Autor:
Michael J. Di Maso, Si-Wei Zhang, Wenjun Liu, Embarek Alwedi, Alfred Y. Lee, Richard Desmond, Hong Ren, Sumei Ren, Karthik Narsimhan, Alexei Kalinin, Kevin M. Maloney, Patrick Larpent
Publikováno v:
Organic Process Research & Development. 24:2491-2497
A scalable two-pot sulfonamidation through the process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c2a51ca82231c4c49ef265b0a9a9741
https://doi.org/10.1021/acs.oprd.0c00247
https://doi.org/10.1021/acs.oprd.0c00247
Autor:
Jinchu Liu, Patrick Larpent, Kallol Basu, Dan Lehnherr, Kevin M. Maloney, Feng Peng, Ryan D. Cohen, Rebecca A. Arvary, Si-Wei Zhang, Nicholas J. Rogus, Michael J. Di Maso, Gary E. Martin, Francisco J. Guzman, Richard Desmond, Hong Ren, Yu-hong Lam, John Y. L. Chung, Zachary E. X. Dance, Michael A. Zompa
Publikováno v:
Organic Process Research & Development. 24:2462-2477
The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate (MK-7264), is described. A full mechanistic u...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac8ade59139d6a18d85322e69f0e2ba
https://doi.org/10.1021/acs.oprd.0c00246
https://doi.org/10.1021/acs.oprd.0c00246
Autor:
Michael J. Di Maso, Embarek Alwedi, Guy R. Humphrey, Richard Desmond, Louis-Charles Campeau, Lisa Jellett, John R. Naber, Hong Ren, Hsieh Yao D. Chang, Douglas A. L. Otte, Hong Gao, Michael A. Zompa, Si-Wei Zhang, Gary E. Martin, Alfred Y. Lee, Wenjun Liu, Francisco J. Guzman, Kevin M. Maloney, Feng Peng, Elizabeth Fisher, Rebecca T. Ruck, Dan Lehnherr, Anne E. Mohan, Glenn Spencer, Siqing Song, Kallol Basu, Rebecca A. Arvary, Sachin Lohani
Publikováno v:
Organic Process Research & Development. 24:2445-2452
A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c8b1da5db499a674207974d58e42c1
https://doi.org/10.1021/acs.oprd.0c00248
https://doi.org/10.1021/acs.oprd.0c00248
Autor:
Michael J. Di Maso, Stephen W. Laws, Q. Nhu N. Nguyen, Dean J. Tantillo, Lucas C. Moore, Jared T. Shaw
Publikováno v:
Organic Letters. 19:2466-2469
A diastereoselective base-catalyzed Mannich reaction of cyclic, enolizable anhydrides and N-sulfonyl imines for the synthesis of δ-lactams is reported. This anhydride Mannich reaction tolerates imines derived from aryl and enolizable aldehydes. A ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41caf20b7f5d1158566bffe99ddfed41
https://doi.org/10.1021/acs.orglett.7b00468
https://doi.org/10.1021/acs.orglett.7b00468
Autor:
Edward I. Balmond, Nolan C. Turman, Jared T. Shaw, Michael J. Di Maso, Elys P. Rodriguez, James C. Fettinger, Marta Castiñeira Reis, Christine A. Dimirjian, Dean J. Tantillo
Publikováno v:
Organic letters, vol 21, iss 18
The formation of fused pyrazoles via intramolecular 1,3-dipolar cycloadditions of diazo intermediates with pendant alkynes is described. A subsequent thermal [1s, 5s] sigmatropic shift of these pyrazole systems resulted in a ring contraction, forming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4928bdb5e75907e9043268d071ebc5
https://escholarship.org/uc/item/8s0418np
https://escholarship.org/uc/item/8s0418np
