Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael J. DePasquale"'
Autor:
Winter Steven Mark, Joan A. Keiser, David Austen Perry, Eileen R. Blasi, Michael J. DePasquale, William T. Loging, Delvin R. Knight, Gregory W Cadelina
Publikováno v:
Drug Development Research. 70:35-48
ILLUMINATE, the Phase 3 clinical trial of morbidity and mortality (MM PF-868,348 is weakly potent and CP-746,281 and CE-308,958 are CETP-inactive. Changes in blood pressure were determined in conscious animals in conjunction with pharmacologic blocka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f5f50afc80cc43b7e99c33c189181f7
https://doi.org/10.1002/ddr.20282
https://doi.org/10.1002/ddr.20282
Publikováno v:
Drug Development Research. 38:105-113
Cardiovascular profiling of developmental compounds by General Pharmacologyl Safety Pharmacology is an integral part of the drug discovery process in support of registration of clinical candidates. Non-invasive screening tools which provide hemodynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09124b17e4ba137adad71a38e07e3133
https://doi.org/10.1002/(sici)1098-2299(199606)38:2<105::aid-ddr4>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199606)38:2<105::aid-ddr4>3.0.co
Publikováno v:
Drug Development Research. 33:422-428
The effects of coadministration of a renin inhibitor, terlakiren, and an angiotensinconverting enzyme inhibitor, captopril, with the angiotensin II receptor antagonist, losartan, on blood pressure of sodium-depleted guinea pigs were studied. Dose-res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ee8cd20789a9a1ebf4f9fc95f6b70e2
https://doi.org/10.1002/ddr.430330405
https://doi.org/10.1002/ddr.430330405
Publikováno v:
Clinical and Experimental Hypertension. 16:245-260
An implantable radio-telemetry device for chronic monitoring of arterial pressure and heart rate in the conscious guinea pig was validated against measurements using an exteriorized, indwelling catheter. There were no significant differences between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7b53291c9f6b90d63961d7d8c47a56
https://doi.org/10.3109/10641969409067952
https://doi.org/10.3109/10641969409067952
Publikováno v:
Hypertension. 19:668-671
Oral administration of the angiotensin II receptor subtype 1 (AT1) antagonist DuP 753 causes long-lasting lowering of mean arterial pressure in spontaneously hypertensive rats. We examined whether the antihypertensive action of DuP 753 is a result of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bad54e95f318112652776ade10165e
https://doi.org/10.1161/01.hyp.19.6.668
https://doi.org/10.1161/01.hyp.19.6.668
Publikováno v:
Journal of pharmacological and toxicological methods. 46(1)
Introduction: The duration of cardiac ventricular depolarization and repolarization is represented as the QT interval. QT prolongation has been associated with the occurrence of arrhythmias. Both cardiovascular as well as noncardiovascular agents hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db31745895936c25ded0afe229999b26
https://pubmed.ncbi.nlm.nih.gov/12164254
https://pubmed.ncbi.nlm.nih.gov/12164254
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 302(2)
QT interval prolongation of the electrocardiogram has been associated with the occurrence of life-threatening fatal ventricular arrhythmias. To understand the relationship between preclinical cardiac conduction assessment to clinical outcome, compari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fd1f0c292893be2a517cb3a7b05631
https://pubmed.ncbi.nlm.nih.gov/12130750
https://pubmed.ncbi.nlm.nih.gov/12130750