Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Michael J. Dart"'
Autor:
John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone, Michael E. Kort
Publikováno v:
Journal of Medicinal Chemistry. 66:3852-3865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941bc4bfb75cae4284f6cb7de0cad715
https://doi.org/10.1021/acs.jmedchem.2c01415
https://doi.org/10.1021/acs.jmedchem.2c01415
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Autor:
Jill-Desiree Brederson, Michael J. Dart, Robert G. Schmidt, Steve McGaraughty, Philip R. Kym, Arthur Gomtsyan, Laura Leys, Katharine L. Chu, Richard J. Radek, Jun Xu
Publikováno v:
Journal of Neurophysiology. 118:904-916
TRPV3 is a nonselective cation channel activated by temperatures above 33°C and is reported to be localized in keratinocytes and nervous tissue. To investigate a role for TRPV3 in pain modulation, we conducted a series of in vivo electrophysiologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b71e35732be381557da3e884c36cd80
https://doi.org/10.1152/jn.00104.2017
https://doi.org/10.1152/jn.00104.2017
Autor:
Nicole V Haste, Diana Donnelly-Roberts, Swathi Krishnan, Lauren LeBon, Jennifer M. Frost, Fiona E. McAllister, Andrea T. Ireland, Yao Liang Wong, Carmela Sidrauski, Stephan Riedmaier, Michael J. Dart, Kathy L. Kohlhaas, Lei Shi, Nimrod D. Rubinstein, Ana M. Basso, Janani Prakash, Kathleen A. Martin, Andrew M. Swensen, Arthur L. Nikkel, Jonathon J. O’Brien, Margaret Ann Roy, Holly M. Robb
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9990114b53b75c88cb58914a496683c
https://doi.org/10.7554/elife.42940
https://doi.org/10.7554/elife.42940
Autor:
Diana L. Donnelly-Roberts, Ana M. Basso, Arthur L. Nikkel, Andrea T. Ireland, Jennifer M. Frost, Lauren LeBon, Carmela Sidrauski, Stephan Riedmaier, Nimrod D. Rubinstein, Holly M. Robb, Kathleen A. Martin, Nicole V Haste, Fiona E. McAllister, Swathi Krishnan, Lei Shi, Margaret Ann Roy, Andrew M. Swensen, Janani Prakash, Jonathon J. O’Brien, Kathy L. Kohlhaas, Yao Liang Wong, Michael J. Dart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebd2110389786065142053652d6bb1f
https://doi.org/10.7554/elife.42940.036
https://doi.org/10.7554/elife.42940.036
Autor:
Philip R. Kym, Arthur Gomtsyan, Gregory A. Gfesser, Bin Li, Regina M. Reilly, Bruce Clapham, Jerome F. Daanen, Rodger F. Henry, Torben R. Neelands, Pamela S. Puttfarcken, Susan M. Huang, Robert G. Schmidt, Robert J. Altenbach, S.K. Joshi, Huaqing Liu, Marlon D. Cowart, David N. Whittern, Phil B. Cox, Jill-Desiree Brederson, Michael J. Dart, Anurupa Shrestha, Donna Gauvin, Michael E. Kort, Erol K. Bayburt, Ping Song, Steve McGaraughty, Connie R. Faltynek, Heath A. McDonald, Patricia N. Banfor, Diana Schmidt, Eric A. Voight, Mohamad Shebley, Jason A. Segreti
Publikováno v:
Journal of Medicinal Chemistry. 59:4926-4947
Transient receptor potential vanilloid 3 (TRPV3) is a Ca(2+)- and Na(+)-permeable channel with a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues, including dorsal root ganglia, spinal cord, and keratinocytes. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1b773984159dd5e2a719a0398228e6
https://doi.org/10.1021/acs.jmedchem.6b00287
https://doi.org/10.1021/acs.jmedchem.6b00287
Autor:
Ana M. Basso, Nimrod D. Rubinstein, Arthur L. Nikkel, Fiona E. McAllister, Jennifer M. Frost, Michael J. Dart, Janani Prakash, Diana Donnelly-Roberts, Kathleen A. Martin, Kathy L. Kohlhaas, Andrew M. Swensen, Lauren LeBon, Lei Shi, Jonathon J. O’Brien, Yao Liang Wong, Stephan Riedmaier, Swathi Krishnan, Nicole V Haste, Carmela Sidrauski, Holly M. Robb
The Integrated Stress Response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792bd23e32b80b51dd87fa6b42310ee3
Autor:
Arthur Gomtsyan, Kort Michael E, Michael J. Dart, Regina M. Reilly, Jason A. Segreti, Heath A. McDonald, Philip R. Kym, Pamela S. Puttfarcken, Robert G. Schmidt, Jerome F. Daanen, Voight Eric
Publikováno v:
Temperature: Multidisciplinary Biomedical Journal
Transient receptor potential vanilloid 1 (TRPV1) is a multifunctional ion channel playing important roles in a numerous biological processes including the regulation of body temperature. Within distinct and tight chemical space of chromanyl ureas TRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97219b310e316ae06bf27bb69c1321c
https://doi.org/10.1080/23328940.2015.1046013
https://doi.org/10.1080/23328940.2015.1046013
Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid-3 (TRPV3) Antagonist
Autor:
Robert G. Schmidt, Jerome F. Daanen, Arthur Gomtsyan, Philip R. Kym, Michael J. Dart, Eric A. Voight
Publikováno v:
The Journal of organic chemistry. 81(23)
An efficient asymmetric synthesis of dipyridyl TRPV3 antagonist 1 is reported. The four-step route involves two C–C bond-forming steps, a highly diastereoselective alkene hydration, and asymmetric ketone hydrosilylation in 97% ee.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c872a552827bd07e374fa2534ad6a6e
https://pubmed.ncbi.nlm.nih.gov/27934457
https://pubmed.ncbi.nlm.nih.gov/27934457
Autor:
B B Yao, William A. Carroll, Jennifer M. Frost, Madhavi Pai, George K. Grayson, Chang Zhu, Bradley A. Hooker, Alan S. Florjancic, Karin R. Tietje, Michael Meyer, Anthony V. Daza, Michael J. Dart, Tiffany Runyan Garrison, Derek W. Nelson, Keith B. Ryther, Gin C. Hsieh, Prasant Chandran, Odile F. El-Kouhen, Yihong Fan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2604-2608
SAR studies on a series of thiophene amide derivatives provided CB(2) receptor agonists. The activity of the compounds was characterized by radioligand binding determination, multiple functional assays, ADME, and pharmacokinetic studies. A representa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cec3e6fc78e745dc4ab01db88eb9d1
https://doi.org/10.1016/j.bmcl.2012.01.121
https://doi.org/10.1016/j.bmcl.2012.01.121