Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael J. Dapp"'
Autor:
Michelle L. Christian, Michael J. Dapp, Samuel C. Scharffenberger, Hank Jones, Chaozhong Song, Lisa M. Frenkel, Anthony Krumm, James I. Mullins, David J. Rawlings
Publikováno v:
The Journal of Immunology. 208:1700-1710
One key barrier to curative therapies for HIV is the limited understanding of HIV persistence. HIV provirus integration sites (ISs) within BACH2 are common, and almost all sites mapped to date are located upstream of the start codon in the same trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7799514edfb2cbd9ae735b276dba668
https://doi.org/10.4049/jimmunol.2100491
https://doi.org/10.4049/jimmunol.2100491
Autor:
Michael J Dapp, Kord M Kober, Lennie Chen, Dylan H Westfall, Kim Wong, Hong Zhao, Breana M Hall, Wenjie Deng, Thomas Sibley, Suvankar Ghorai, Katie Kim, Natalie Chen, Sarah McHugh, Lily Au, Mardge Cohen, Kathryn Anastos, James I Mullins
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0182443 (2017)
Biological sex differences affect the course of HIV infection, with untreated women having lower viral loads compared to their male counterparts but, for a given viral load, women have a higher rate of progression to AIDS. However, the vast majority
Externí odkaz:
https://doaj.org/article/977db700df844816af228a3f9d60a525
Autor:
Michelle L, Christian, Michael J, Dapp, Samuel C, Scharffenberger, Hank, Jones, Chaozhong, Song, Lisa M, Frenkel, Anthony, Krumm, James I, Mullins, David J, Rawlings
Publikováno v:
J Immunol
One key barrier to curative therapies for HIV is the limited understanding of HIV persistence. HIV provirus integration sites (IS) within BACH2 are common, and almost all sites mapped to date are located upstream of the start codon in the same transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d00b24d0eb5be250debcb996adc12161
https://pubmed.ncbi.nlm.nih.gov/35264460
https://pubmed.ncbi.nlm.nih.gov/35264460
Autor:
Hong Zhao, Lily Au, Kathryn Anastos, Mardge H. Cohen, Lennie Chen, Kord M. Kober, Katie B. Kim, Kim G. Wong, Michael J. Dapp, Natalie Y. Chen, Suvankar Ghorai, Dylan H. Westfall, Thomas H. Sibley, Breana Hall, Sarah McHugh, Wenjie Deng, James I. Mullins
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0182443 (2017)
PloS one, vol 12, iss 10
PLoS ONE
PloS one, vol 12, iss 10
PLoS ONE
Biological sex differences affect the course of HIV infection, with untreated women having lower viral loads compared to their male counterparts but, for a given viral load, women have a higher rate of progression to AIDS. However, the vast majority
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9819f41f46c402aa4d196980c925cf7e
http://europepmc.org/articles/PMC5646779?pdf=render
http://europepmc.org/articles/PMC5646779?pdf=render
Publikováno v:
Journal of Virology. 88:354-363
Reverse transcription is an important early step in retrovirus replication and is a key point targeted by evolutionarily conserved host restriction factors (e.g., APOBEC3G, SamHD1). Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40637d12016f74cd1daeb4d44c7d64d
https://doi.org/10.1128/jvi.02444-13
https://doi.org/10.1128/jvi.02444-13
Autor:
Louis M. Mansky, Jessica L. Martin, Michael J. Dapp, Richard H. Heineman, Steven E. Patterson, Erica Schnettler, Jonathan M.O. Rawson, Lauren B. Beach
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:7222-7228
The nucleoside analog 5,6-dihydro-5-aza-2'-deoxycytidine (KP-1212) has been investigated as a first-in-class lethal mutagen of human immunodeficiency virus type-1 (HIV-1). Since a prodrug monotherapy did not reduce viral loads in Phase II clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a8db7227a16260bdd616f722d9300e
https://doi.org/10.1016/j.bmc.2013.08.023
https://doi.org/10.1016/j.bmc.2013.08.023
Publikováno v:
Trends in Microbiology. 21:56-62
The concept of eliminating HIV-1 infectivity by elevating the viral mutation rate was first proposed over a decade ago, even though the general concept had been conceived earlier for RNA viruses. Lethal mutagenesis was originally viewed as a novel ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b57e73febe79858059773ab7c87b0e
https://doi.org/10.1016/j.tim.2012.10.006
https://doi.org/10.1016/j.tim.2012.10.006
Publikováno v:
Journal of Molecular Biology. 425:41-53
Differences in replication fidelity, as well as mutator and antimutator strains, suggest that virus mutation rates are heritable and prone to natural selection. Human immunodeficiency virus type 1 (HIV-1) has many distinct advantages for the study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9df450d1c139d7deef296f93e6f485
https://doi.org/10.1016/j.jmb.2012.10.009
https://doi.org/10.1016/j.jmb.2012.10.009
Publikováno v:
Journal of Molecular Biology. 419:158-170
RNA virus population dynamics is complex, and sophisticated approaches are needed in many cases for therapeutic intervention. One such approach, termed lethal mutagenesis, is directed at targeting the virus population structure for extinction or erro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505a81888ec94adaefd525ca0f34de22
https://doi.org/10.1016/j.jmb.2012.03.003
https://doi.org/10.1016/j.jmb.2012.03.003
Publikováno v:
Journal of virology. 83(22)
Ribonucleosides inhibit human immunodeficiency virus type 1 (HIV-1) replication by mechanisms that have not been fully elucidated. Here, we report the antiviral mechanism for the ribonucleoside analog 5-azacytidine (5-AZC). We hypothesized that the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3570fb3920b3423c405130c73e25b2
https://pubmed.ncbi.nlm.nih.gov/19726509
https://pubmed.ncbi.nlm.nih.gov/19726509