Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael J. Dagley"'
Autor:
Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa, Wai K. Lam, Michael J. Dagley, Eleanor C. Saunders, Lisa M. Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E. van de Sandt, Lucy Cooper, Kim L. Good-Jacobson, Katherine Kedzierska, Laura K. Mackay, Malcolm J. McConville, Georg Ramm, Michael T. Ryan, Nicole L. La Gruta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have hig
Externí odkaz:
https://doaj.org/article/6da73ceced984a059e48b4f7619a183a
Autor:
Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa, Wai K. Lam, Michael J. Dagley, Eleanor C. Saunders, Lisa M. Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E. van de Sandt, Lucy Cooper, Kim L. Good-Jacobson, Katherine Kedzierska, Laura K. Mackay, Malcolm J. McConville, Georg Ramm, Michael T. Ryan, Nicole L. La Gruta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/4bb3b23071da4efa94de40dde3087b1f
Publikováno v:
F1000Research, Vol 4 (2015)
A number of medically important microbial pathogens target and proliferate within macrophages and other phagocytic cells in their mammalian hosts. While the majority of these pathogens replicate within the host cell cytosol or non-hydrolytic vacuolar
Externí odkaz:
https://doaj.org/article/bb66b0dbb93644a78b9bab2d0b3ac3a0
Autor:
Jiyoti Verma-Gaur, Yue Qu, Paul F Harrison, Tricia L Lo, Tara Quenault, Michael J Dagley, Matthew Bellousoff, David R Powell, Traude H Beilharz, Ana Traven
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005590 (2015)
The yeast Candida albicans is a human commensal and opportunistic pathogen. Although both commensalism and pathogenesis depend on metabolic adaptation, the regulatory pathways that mediate metabolic processes in C. albicans are incompletely defined.
Externí odkaz:
https://doaj.org/article/26d369bd1bb9478b876a665e3593e08e
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004683 (2015)
Information on the growth rate and metabolism of microbial pathogens that cause long-term chronic infections is limited, reflecting the absence of suitable tools for measuring these parameters in vivo. Here, we have measured the replication and physi
Externí odkaz:
https://doaj.org/article/ac267e0f616f4038bcbfe85880fcc2ec
Autor:
Erica Wynne-Jones, Kylie M. Quinn, Lisa M Assmus, Kim L. Good-Jacobson, Laura K. Mackay, Carolien E. van de Sandt, Georg Ramm, Wai K Lam, Tabinda Hussain, Michael J Dagley, Nicole L. La Gruta, Liyen Loh, Malcolm J. McConville, Katherine Kedzierska, Michael T. Ryan, Lucy Cooper, Felix Kraus, Luke E. Formosa, Eleanor C Saunders
Publikováno v:
Nature communications, 11(1):2857. Nature Publishing Group
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked proliferative dysfunction in advanced age. High spare respiratory capacity (SRC) has been proposed as a defining metabolic chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b9d439a40478ff5044380707195fc4
https://doi.org/10.1038/s41467-020-16633-7
https://doi.org/10.1038/s41467-020-16633-7
Autor:
Michael J Dagley, Erica Wynne-Jones, Laura K. Mackay, Felix Kraus, Georg Ramm, Wai K Lam, Kylie M. Quinn, Lisa M Assmus, Malcolm J. McConville, Luke E. Formosa, Michael T. Ryan, Katherine Kedzierska, Liyen Loh, Carolien E. van de Sandt, Nicole L. La Gruta, Lucy Cooper, Eleanor C Saunders, Tabinda Hussain, Kim L. Good-Jacobson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications
Nature Communications
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publikováno v:
Bioinformatics
Summary Stable isotope directed metabolomics is increasingly being used to measure metabolic fluxes in microbial, plant and animal cells. Incorporation of 13C/15N isotopes into a wide range of metabolites is typically determined using gas chromatogra
Publikováno v:
ASSAY and Drug Development Technologies. 13:389-401
Leishmania species are sandfly-transmitted protozoan parasites that cause a spectrum of diseases, ranging from localized skin lesions to fatal visceral disease, in more than 12 million people worldwide. These parasites primarily target macrophages in
Autor:
Martin Blume, Michael J Dagley, Joachim Kloehn, Malcolm J. McConville, Simon A. Cobbold, Eleanor C Saunders
Publikováno v:
Current opinion in microbiology. 32
Protozoan parasites have evolved diverse growth and metabolic strategies for surviving and proliferating within different extracellular and intracellular niches in their mammalian hosts. Metabolomic approaches, including high coverage metabolite prof