Výsledky vyhledávání - "Michael J. Currens"

Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα

Autor: Michael J. Currens, Thomas G. McCloud, Dominic A. Scudiero, Paul Klausmeyer, Robert H. Shoemaker, John H. Cardellina

Publikováno v: Bioorganic & Medicinal Chemistry. 20:4646-4652

A high throughput in vitro screen has been developed to identify substances that induce expression of C/EBPα in tumor cells. An extract of the fruit of Gyrocarpus jacquinii showed induction of C/EBPα activity that was attributed by dereplication an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaad7674733decdc0049abe5ac121426
https://doi.org/10.1016/j.bmc.2012.06.017

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Chemical library screen for novel inhibitors of Kaposi's sarcoma-associated herpesvirus processive DNA synthesis

Autor: Xulin Chen, Michael J. Currens, Weimin Zhu, Paula E. Roberts, Glenn N. Gray, Angela Burnette, Robert H. Shoemaker, Robert P. Ricciardi, Shizuko Sei, Dorjbal Dorjsuren

Publikováno v: Antiviral Research. 69:9-23

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma and certain lymphoproliferative disorders. The role of KSHV lytic replication has been implicated in the tumor pathogenesis. A highly specific molecular complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebf68668f8449fbeb141dc1598d3d22
https://doi.org/10.1016/j.antiviral.2005.09.005

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Isolation and Characterization of Myrianthus holstii Lectin, a Potent HIV-1 Inhibitory Protein from the Plant Myrianthus holstii

Autor: Murray H. G. Munro, Raymond C. Sowder, Michael R. Boyd, Lewis K. Pannell, Tawnya C. McKee, Romila D. Charan, Michael J. Currens, Barry R. O'Keefe

Publikováno v: Journal of Natural Products. 63:1170-1174

Aqueous extracts from the African plant Myrianthus holstii potently inhibited the infection of the T-lymphoblastoid cell line, CEM-SS, by human immunodeficiency virus-1 RF (HIV-1 RF ). The active constituent, M. holstii lectin (MHL), was purified by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::196521d9e0b09b6a8edd3174a3c4fbad
https://doi.org/10.1021/np000039h

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HIV-Inhibitory Gallotannins fromLepidobotrys staudtii

Autor: Michael J. Currens, Tawnya C. McKee, Michael R. Boyd, Heidi R. Bokesch, John H. Cardellina, James B. McMahon, Robert J. Gulakowski

Publikováno v: Natural Product Letters. 8:133-136

Three galloylquinic acids, 1,3,4,5-tetra-O-galloylquinic acid (1), 3,4,5-tri-O-galloylquinic acid (2), and methyl 3,4,5-tri-O-galloylquinate (3) were isolated from the stem bark of the monotypic plant Lepidobotrys staudtii. Compound 1 protected targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98100def4b24a42149aa928f348f6c01
https://doi.org/10.1080/10575639608043252

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Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups

Autor: Valerie Fliakas-Boltz, Michael R. Boyd, Michael J. Currens, Tracy L. Stup, Joseph L. Roberson, William Decker, C A Pyle, E L White, James B. McMahon, Robert W. Buckheit

Publikováno v: Antiviral Research. 26:117-132

We have biologically and biochemically evaluated a structurally diverse group of HIV-1-specific reverse transcriptase (RT) inhibitors and determined that the members of this class share many common properties. These include reproducible and selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb56f747810d46cabb7378f11f61284
https://doi.org/10.1016/0166-3542(94)00069-k

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RSK2 Binding Models Delineate Key Features for Activity

Autor: Rick, Gussio, Michael J, Currens, Dominic A, Scudiero, Jeffrey A, Smith, Deborah A, Lannigan, Robert H, Shoemaker, Dan W, Zaharevitz, Tam Luong, Nguyen

Publikováno v: Journal of chemical and pharmaceutical research. 2(5)

Due to its overexpression and activation in human cancer cells and tissues, an emerging molecular target in cancer therapeutics is p90 ribosomal s6 kinase 2 (RSK2). While a growing number of RSK2 inhibitors have been reported in the literature, only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::222fa3c5ac8b528cb7ec3993678b9ea6
https://pubmed.ncbi.nlm.nih.gov/21593990

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Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase

Autor: Michael J. Currens, P L Boyer, James B. McMahon, Stephen H. Hughes, Michael R. Boyd

Publikováno v: Journal of Virology. 67:2412-2420

A number of chemically distinct nonnucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) have been reported. Several lines of evidence, including the isolation of RT mutants that show cross resistance, sugges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59370bbe67905b83a1a5085dc8650f24
https://doi.org/10.1128/jvi.67.4.2412-2420.1993

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HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum

Autor: Stephen H. Hughes, Kirk R. Gustafson, Yoel Kashman, Gordon M. Cragg, James B. McMahon, Michael R. Boyd, Michael J. Currens, John H. Cardellina, Robert W. Buckheit, Richard W. Fuller

Publikováno v: Journal of Medicinal Chemistry. 35:2735-2743

Eight new coumarin compounds (1-8) were isolated by anti-HIV bioassay-guided fractionation of an extract of Calophyllum lanigerum. The structures of calanolide A (1), 12-acetoxycalanolide A (2), 12-methoxycalanolide A (3), calanolide B (4), 12-methox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e6df1ff128c99f2852a9a7062144119
https://doi.org/10.1021/jm00093a004

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Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2′,3′-dideoxyguanosine

Autor: David A. Cooney, David G. Johns, Hiroaki Mitsuya, Laureano L. Bondoc, Harry Ford, Michael J. Currens, Arnold Fridland, Gurpreet S. Ahluwalia

Publikováno v: Biochemical and Biophysical Research Communications. 171:1297-1303

The inosinate dehydrogenase (IMPD) inhibitors ribavirin, tiazofurin and mycophenolic acid were found to stimulate by as much as 20-fold the anabolism of the anti-HIV agent 2' ,3'dideoxyguanosine to its 5'-diphosphate (ddGDP) in a human T-cell culture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3b112ab4ce82b5b2d83fbcc378dc77
https://doi.org/10.1016/0006-291x(90)90827-a

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