Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Michael J. Coffey"'
Autor:
Michael J. Coffey, Laura F. Dagley, Simona Seizova, Eugene A. Kapp, Giuseppe Infusini, David S. Roos, Justin A. Boddey, Andrew I. Webb, Christopher J. Tonkin
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Toxoplasma gondii infects approximately 30% of the world’s population, causing disease primarily during pregnancy and in individuals with weakened immune systems. Toxoplasma secretes and exports effector proteins that modulate the host dur
Externí odkaz:
https://doaj.org/article/ea7a3291199047328178731b63d09cfa
Autor:
Adit Naor, Michael W. Panas, Nicole Marino, Michael J. Coffey, Christopher J. Tonkin, John C. Boothroyd
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT The obligate intracellular parasite Toxoplasma gondii controls its host cell from within the parasitophorous vacuole (PV) by using a number of diverse effector proteins, a subset of which require the aspartyl protease 5 enzyme (ASP5) and/or
Externí odkaz:
https://doaj.org/article/7435798edd5842b18076726fbe510eb7
Autor:
Michael J Coffey, Ivan Low, Sacha Stelzer-Braid, Bernd Wemheuer, Millie Garg, Torsten Thomas, Adam Jaffe, William D Rawlinson, Chee Y Ooi
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233557 (2020)
Intestinal bacterial dysbiosis is evident in children with cystic fibrosis (CF) and intestinal viruses may be contributory, given their influence on bacterial species diversity and biochemical cycles. We performed a prospective, case-control study on
Externí odkaz:
https://doaj.org/article/1b4788400dab4b23be75642ad0d102a2
Autor:
Isabelle, Traini, Sin Yee, Chan, Jessica, Menzies, Jennifer, Hughes, Michael J, Coffey, Tamarah, Katz, Isabelle R, McKay, Chee Y, Ooi, Steven T, Leach, Usha, Krishnan
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 75:221-226
Children with esophageal atresia (EA) often have feeding difficulties and dysphagia, which may compromise their nutritional status. This study aimed to compare dietary intake between children with EA and matched healthy controls (HC) and to investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3113d0eefd8370388ed530d165af936a
https://doi.org/10.1097/mpg.0000000000003498
https://doi.org/10.1097/mpg.0000000000003498
Autor:
Alessandro D Uboldi, Mary-Louise Wilde, Emi A McRae, Rebecca J Stewart, Laura F Dagley, Luning Yang, Nicholas J Katris, Sanduni V Hapuarachchi, Michael J Coffey, Adele M Lehane, Cyrille Y Botte, Ross F Waller, Andrew I Webb, Malcolm J McConville, Christopher J Tonkin
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2005642 (2018)
The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stages and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca2+ signalling activates motili
Externí odkaz:
https://doaj.org/article/b74ca0993f11485cab44baf31f1908a9
Autor:
Michael J. Coffey, Chee Y. Ooi
Publikováno v:
Journal of Paediatrics and Child Health. 56:1694-1701
Paediatric pancreatic diseases are often under-recognised and may be associated with severe diseases and significant clinical consequences. In recent years, advances have been made in key areas, particularly with the contributions from international
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bca666c7acf302faa91d59f1893356
https://doi.org/10.1111/jpc.14688
https://doi.org/10.1111/jpc.14688
Autor:
Nitin Gupta, Rosie Sutherland, Michael J. Coffey, Chai Wei Tong, Alison Ting, Daniel A. Lemberg, Victoria Liu, Yajuan Gao, Tamarah Katz, Usha Krishnan, Chee Y. Ooi
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 71:246-251
Objectives Children with celiac disease (CD) follow a lifelong gluten-free diet. This restrictive diet may be associated with nutritional compromise. Our objectives were, therefore, to evaluate the dietary composition (energy, macronutrients and micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d9bdfb4da12f20661458ccc0a15846
https://doi.org/10.1097/mpg.0000000000002743
https://doi.org/10.1097/mpg.0000000000002743
Autor:
Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin
Publikováno v:
eLife, Vol 4 (2015)
Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained a
Externí odkaz:
https://doaj.org/article/87c2bb0c16e043169ac8333f604bb8e0
Autor:
Simona Seizova, Ushma Ruparel, Alexandra L. Garnham, Stefanie M. Bader, Alessandro D. Uboldi, Michael J. Coffey, Lachlan W. Whitehead, Kelly L. Rogers, Christopher J. Tonkin
Publikováno v:
Cell hostmicrobe. 30(2)
Toxoplasma gondii develops a latent infection in the muscle and central nervous system that acts as a reservoir for acute-stage reactivation in vulnerable patients. Little is understood about how parasites manipulate host cells during latent infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d2d611d72bbd0636275f5611b82f71
https://pubmed.ncbi.nlm.nih.gov/34921775
https://pubmed.ncbi.nlm.nih.gov/34921775
Publikováno v:
Journal of Cystic Fibrosis. 18:857-862
Background Meconium ileus (MI) affects up to 20% of newborns with cystic fibrosis (CF). We compared clinical outcomes between Australian paediatric CF patients with and without meconium ileus (non-MI). Methods This was a retrospective case-control st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293fc05e845b6b9233325da8b7da464f
https://doi.org/10.1016/j.jcf.2019.09.008
https://doi.org/10.1016/j.jcf.2019.09.008