Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2

Autor: Aysegul Atasoy-Zeybek, Michael J. Coenen, Gresin P. Hawse, Delphine Logeart-Avramoglou, Christopher H. Evans, Rodolfo E. De La Vega

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 350-363 (2023)

Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclin

Externí odkaz: https://doaj.org/article/a6616c8594034237bd2d18ec1d533163

Lentiviral-based BMP4 in vivo gene transfer strategy increases pull-out tensile strength without an improvement in the osteointegration of the tendon graft in a rat model of biceps tenodesis

Autor: Jon E. Wergedal, Michael J. Coen, Shin-Tai Chen, Charles H. Rundle, Kin-Hing William Lau

Publikováno v: The Journal of Gene Medicine. 13:511-521

Background The present study aimed to develop a rat model of biceps tenodesis and to assess the feasibility of a lentiviral (LV)-based bone morphogenetic protein (BMP) 4 in vivo gene transfer strategy for healing of biceps tenodesis. Methods A rat mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a59882821f2f70675030fe55d3eb799
https://doi.org/10.1002/jgm.1604

The dimpling phenomenon: Articular cartilage injury overlying an occult osteochondral lesion at the time of anterior cruciate ligament reconstruction

Autor: Darren L. Johnson, David N.M. Caborn, Michael J. Coen

Publikováno v: Arthroscopy: The Journal of Arthroscopic & Related Surgery. 12:502-505

The authors report the arthroscopic finding of articular cartilage "dimpling" when a probe is placed onto the discrete chondral area involved over the geographic bone bruise incurred during traumatic anterior cruciate ligament disruption. As we devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181314f15e8ae6c3f24d5116c1a55f19
https://doi.org/10.1016/s0749-8063(96)90051-1

Contributors

Autor: Christopher S. Ahmad, Answorth A. Allen, David W. Altchek, Laurie B. Amundsen, Kai-Nan An, Ludwig Anné, Carl J. Basamania, Alexander Bertlesen, Kamal I. Bohsali, John J. Brems, Stephen F. Brockmeier, Robert H. Brophy, Barrett S. Brown, Ernest M. Burgess, Wayne Z. Burkhead, Gilbert Chan, Paul D. Choi, Jeremiah Clinton, Michael Codsi, Michael J. Coen, Robert H. Cofield, David N. Collins, Ernest U. Conrad, Frank A. Cordasco, Edward Craig, Jeffrey Davila, Anthony F. DePalma, David M. Dines, Joshua S. Dines, Mark C. Drakos, Anders Ekelund, Neal S. ElAttrache, Bassem ElHassan, Nathan K. Endres, Stephen Fealy, Edward V. Fehringer, John M. Fenlin, John M. (Jack) Flynn, Leesa M. Galatz, Seth C. Gamradt, Charles L. Getz, Guillem Gonzalez-Lomas, Thomas P. Goss, Manuel Haag, Peter Habermayer, Manny Halpern, Jo A. Hannafin, Laurence D. Higgins, Jason L. Hurd, Joseph P. Iannotti, Eiji Itoi, Kirk L. Jensen, Christopher M. Jobe, Anne M. Kelly, Christopher D. Kent, Laurent Lafosse, Clayton Lane, Peter Lapner, Kenneth Lin, Steven B. Lippitt, Joachim F. Loehr, John D. MacGillivray, Frederick A. Matsen, Jesse McCarron, Bernard F. Morrey, Andrew S. Neviaser, Stephen J. O'Brien, Brett D. Owens, Wesley P. Phipatanakul, Robin R. Richards, Charles A. Rockwood, Scott A. Rodeo, Robert L. Romano, Ludwig Seebauer, Peter T. Simonian, David L. Skaggs, Douglas G. Smith, John W. Sperling, Robert J. Spinner, Scott P. Steinmann, Daniel P. Tomlinson, Hans K. Uhthoff, Todd W. Ulmer, Tom Van Isacker, Jennifer L. Vanderbeck, James E. Voos, Christopher J. Wahl, Gilles Walch, Jon J.P. Warner, Russell F. Warren, Anthony S. Wei, Jason S. Weisstein, Gerald R. Williams, Riley J. Williams, Michael A. Wirth, Joseph D. Zuckerman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b6f2f88e5353473b75e9b1569a26ecf
https://doi.org/10.1016/b978-1-4160-3427-8.50006-4

Direct Lentiviral-Cyclooxygenase 2 Application to the Tendon-Bone Interface Promotes Osteointegration and Enhances Return of the Pull-Out Tensile Strength of the Tendon Graft in a Rat Model of Biceps Tenodesis

Autor: Michael J. Coen, Shin-Tai Chen, Kin-Hing William Lau, Virginia Stiffel, Charles H. Rundle, Jon E. Wergedal

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e98004 (2014)

This study sought to determine if direct application of the lentiviral (LV)-cyclooxygenase 2 (COX2) vector to the tendon-bone interface would promote osteointegration of the tendon graft in a rat model of biceps tenodesis. The LV-COX2 gene transfer s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457a0e654e28bade77142618a056693a
https://doi.org/10.1371/journal.pone.0098004