Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Michael J. Chao"'
Autor:
Manav Kapoor, Michael J. Chao, Emma C. Johnson, Gloriia Novikova, Dongbing Lai, Jacquelyn L. Meyers, Jessica Schulman, John I. Nurnberger, Bernice Porjesz, Yunlong Liu, The Collaborative Study on the Genetics of Alcoholism (COGA), Tatiana Foroud, Howard J. Edenberg, Edoardo Marcora, Arpana Agrawal, Alison Goate
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Alcohol use disorder and drinks per week both have been studied genetically and have different correlations with psychiatric diseases. Here the authors integrate multi-omics data to identify unique and shared variants, genes and pathways for alcohol
Externí odkaz:
https://doaj.org/article/2f7874ae384e400ab64698142f8c1fce
Autor:
Michael J Chao, Kyung-Hee Kim, Jun Wan Shin, Diane Lucente, Vanessa C Wheeler, Hong Li, Jared C Roach, Leroy Hood, Nancy S Wexler, Laura B Jardim, Peter Holmans, Lesley Jones, Michael Orth, Seung Kwak, Marcy E MacDonald, James F Gusella, Jong-Min Lee
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007274 (2018)
Modifiers of Mendelian disorders can provide insights into disease mechanisms and guide therapeutic strategies. A recent genome-wide association (GWA) study discovered genetic modifiers of Huntington's disease (HD) onset in Europeans. Here, we perfor
Externí odkaz:
https://doaj.org/article/5931f4866f45429eade3b1d4c42f0e25
Autor:
Maojuan Zhuang, Evan Udine, Roberto A. Ortega, Susan Bressman, Madison Parks, Deborah Raymond, Ritesh A. Ramdhani, Vicki Shanker, Katia de Paiva Lopes, Michael J. Chao, John F. Crary, Steven J. Frucht, Lotje de Witte, Gijsje J. L. J. Snijders, Matthew Swan, Towfique Raj, Elisa Navarro, Ruth H. Walker, Ana C. Pereira, Amanda Allan, Tim Ahfeldt, Jack Humphrey, Charalambos Argyrou, Sarah Simon, Winona Tse, Brooklyn Henderson, Sonya Elango, Rachel Saunders-Pullman, Alison Goate, Tamjeed Sikder, Brian M. Schilder, Carolyn W. Zhu, Ricardo Assunção Vialle, Kurt Farrell, Giulietta Riboldi, Mary Sano
Publikováno v:
Nat Aging
An increasing number of identified Parkinson’s disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their role in pathology is not understood. We hypothesized that PD susceptibility genes modulate disease risk by influe
Autor:
Julia TCW, Lu Qian, Nina H. Pipalia, Michael J. Chao, Shuang A. Liang, Yang Shi, Bharat R. Jain, Sarah E. Bertelsen, Manav Kapoor, Edoardo Marcora, Elizabeth Sikora, Elizabeth J. Andrews, Alessandra C. Martini, Celeste M. Karch, Elizabeth Head, David M. Holtzman, Bin Zhang, Minghui Wang, Frederick R. Maxfield, Wayne W. Poon, Alison M. Goate
Publikováno v:
Cell, vol 185, iss 13
Cell
Cell
The impact of Apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer’s disease (AD), on human brain cellular function remains unclear. Here we investigated the effects of APOE4 on brain cell types derived from population and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b0949c382efaebe1af48a71c238674
https://escholarship.org/uc/item/3hm0v2gr
https://escholarship.org/uc/item/3hm0v2gr
Autor:
Christopher Medway, Vanessa C. Wheeler, Diane Lucente, Amelia Tee, Douglas Barker, Seung Kwak, Anka G Ehrhardt, Jean Paul Vonsattel, Kevin Correia, Michael J. Chao, Jacob M. Loupe, Darren G. Monckton, Alastair Maxwell, Jayalakshmi S. Mysore, Lesley Jones, Michael Orth, Richard H. Myers, Thomas Massey, Hugh Rickards, Ira Shoulson, Timothy Stone, Kyung Hee Kim, Marcy E. MacDonald, Marc Ciosi, Branduff McAllister, Erik van Duijn, Lynsey Hall, Tammy Gillis, Duncan McLauchlan, Jong-Min Lee, Ricardo Mouro Pinto, James F. Gusella, Eliana Marisa Ramos, Eun Pyo Hong, Jane S. Paulsen, Peter Holmans, G. Bernhard Landwehrmeyer, Cristina Sampaio, Afroditi Chatzi, Natalie Ellis, Kawther Abu Elneel, Jeffrey D. Long
Publikováno v:
Biological Psychiatry
Biological Psychiatry, 87(9), 857-865. ELSEVIER SCIENCE INC
Biological Psychiatry, 87(9), 857-865. ELSEVIER SCIENCE INC
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene. It is diagnosed following a standardized exam of motor control and often presents with cognitive decline and psychiatric symptoms
Autor:
Leslie M. Shaw, Angela L. Jefferson, David A. Bennett, Alison Goate, Timothy J. Hohman, Eric B. Larson, Nancy J. Cox, Marilyn S. Albert, Michael J. Chao, Lisa L. Barnes, Brian W. Kunkle, William S. Bush, Jonathan L. Haines, Paul K. Crane, Walter A. Kukull, Henrik Zetterberg, C. Dirk Keene, Yuetiva Deming, Gerard D. Schellenberg, Shubhabrata Mukherjee, Carlos Cruchaga, Thomas J. Montine, Kaj Blennow, Kara L. Hamilton-Nelson, Matthew J. Huentelman, John Q. Trojanowski, Philip L. De Jager, Elaine R. Peskind, Logan Dumitrescu, Eden R. Martin, Julie A. Schneider, Madhav Thambisetty, Gary W. Beecham, Susan M. Resnick, Sterling C. Johnson, Katherine A. Gifford, Margaret A. Pericak-Vance, Lori B. Chibnik
Publikováno v:
Brain
Autopsy measures of Alzheimer’s disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However, despite evidence of sex differences in Alzheimer’s disease risk, sex-stratified models have
Autor:
Debby W. Tsuang, Robert S. Wilson, Michael J. Chao, Alan E. Renton, Kelley Faber, Tatiana Foroud, Richard Mayeux, Allison Goate, Dolly Reyes-Dumeyer, Robert A. Sweet, Badri N. Vardarajan, David A. Bennett, Roger N. Rosenberg, Margaret A. Pericak-Vance, B. F. Boeve, Carlos Cruchaga, Haines Jl
INTRODUCTIONThe National Institute on Aging Late-Onset Alzheimer’s Disease Family Based Study (NIA-LOAD FBS) was established to study the genetic etiology of Alzheimer’s disease (AD).METHODSRecruitment focused on families with two living affected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42daac904793f9bff0be594c49d0e251
https://doi.org/10.1101/2021.04.12.21255332
https://doi.org/10.1101/2021.04.12.21255332
Autor:
Julianna Y. Lee, Tom Massey, Jane S. Paulsen, Elizabeth Aylward, JN D Stone, Nigel Williams, Darren G. Monckton, Jasmine Donaldson, Georg Bernhard Landwehrmeyer, Peter Holmans, Lyn Elliston, Chughtai U, Anne Elizabeth Rosser, Branduff McAllister, Lesley Jones, Georgina E. Menzies, Schuhmacher L, S. V. Lobanov, Sophie Powell, Michael J. Chao, Binda Cs, Wheeler, Marc Ciosi, Alastair Maxwell, Marcy E. MacDonald, J. F. Gusella, Diane Lucente, Edwards G, Nicholas D. Allen, Jeffrey D. Long, E. Rees, Eun Pyo Hong
SummaryThe age at onset of motor symptoms in Huntington’s disease (HD) is driven by HTT CAG repeat length but modified by other genes. We used exome sequencing of 683 HD patients with extremes of onset or phenotype relative to CAG length to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::186d09a6104703c0de6b1a80e06b7c7c
https://doi.org/10.1101/2021.04.13.439716
https://doi.org/10.1101/2021.04.13.439716
Autor:
Marcy E. MacDonald, Michael J. Chao, Eun Pyo Hong, Darren G. Monckton, Vanessa C. Wheeler, Thomas Massey, Diane Lucente, Marc Ciosi, James F. Gusella, Seung Kwak, Michael Orth, Lesley Jones, Jeffrey D. Long, Peter Holmans, S. V. Lobanov, Jong-Min Lee, Branduff McAllister
Publikováno v:
J Huntingtons Dis
Background: Huntington’s disease (HD) is caused by an expanded (>35) CAG trinucleotide repeat in huntingtin (HTT). Age-at-onset of motor symptoms is inversely correlated with the size of the inherited CAG repeat, which expands further in brain regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9405f24d10bbcd11d606ef38db8714f
https://orca.cardiff.ac.uk/id/eprint/143934/1/GWA12345.XWAS.Accepted.Author.Manuscript.pdf
https://orca.cardiff.ac.uk/id/eprint/143934/1/GWA12345.XWAS.Accepted.Author.Manuscript.pdf
Autor:
Julia T.C.W., Shuang A. Liang, Elizabeth Sikora, Wayne W. Poon, Sarah Bertelsen, Lu Qian, Manav Kapoor, Minghui Wang, David M. Holtzman, Frederick R. Maxfield, Yang Shi, Alison Goate, Michael J. Chao, Nina H. Pipalia, Bin Zhang, Edoardo Marcora
Publikováno v:
Alzheimer's & Dementia. 16