Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michael J. Caspers"'
Autor:
Robert D. Winefield, Swetha Kaul, Anthonius A. M. Heemskerk, Todd D. Williams, Michael J. Caspers, Morris D. Faiman, Elinore F. McCance-Katz, Craig E. Lunte, Thomas E. Prisinzano
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 107:518-525
Disulfiram (DSF), a treatment for alcohol use disorders, has shown some clinical effectiveness in treating addiction to cocaine, nicotine, and pathological gambling. The mechanism of action of DSF for treating these addictions is unclear but it is un
Autor:
Matthew W. Johnson, Katherine A. MacLean, Thomas E. Prisinzano, Michael J. Caspers, Roland R. Griffiths
Publikováno v:
Journal of psychopharmacology (Oxford, England). 30(4)
Salvinorin A is a kappa opioid agonist and the principal psychoactive constituent of the Salvia divinorum plant, which has been used for hallucinogenic effects. Previous research on salvinorin A pharmacokinetics likely underestimated plasma levels ty
Autor:
Justin T. Douglas, Michael J. Caspers, Richard B. Rothman, Christina M. Dersch, Anthony Lozama, Thomas E. Prisinzano, Christopher W. Cunningham
Publikováno v:
Journal of Natural Products. 74:718-726
As part of our continuing efforts toward more fully understanding the structure-activity relationships of the neoclerodane diterpene salvinorin A, we report the synthesis and biological characterization of unique cycloadducts through [4+2] Diels-Alde
Autor:
Mary Jeanne Kreek, Eduardo R. Butelman, Michael J. Caspers, Kimberly M. Lovell, Thomas E. Prisinzano
Active blood-brain barrier mechanisms, such as the major efflux transporter P-glycoprotein (mdr1), modulate the in vivo/central nervous system (CNS) effects of many pharmacological agents, whether they are used for nonmedical reasons or in pharmacoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bf985593faf1244c2ee124087f56bb
https://europepmc.org/articles/PMC3362888/
https://europepmc.org/articles/PMC3362888/
Autor:
Eduardo R. Butelman, Mary Jeanne Kreek, Matthew W. Johnson, Roland R. Griffiths, Kimberly M. Lovell, Thomas E. Prisinzano, Michael J. Caspers, Katherine A. MacLean, Anthony Lozama, Todd D. Williams
Publikováno v:
Analytical Methods. 5:7042
A facile method for quantifying the concentration of the powerful and widely available hallucinogen salvinorin A (a selective kappa opioid agonist) from non-human primate cerebrospinal fluid (CSF) and human plasma has been developed using liquid chro