Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Michael J. Broadhurst"'
Autor:
F. Rose, E. Worth, N. Lad, D. S. Walter, Robert C.G. Martin, K. Wilson, Michael J. Broadhurst, J. Kneer, David Bradshaw, J. Nixon, A. Rodwell, R. Mackenzie, William Henry Johnson, J.-P. Tang, Hill Christopher Huw, S. Kirtland, H.-J. Kim, M. Brewster, G. Beck, R. Devos, G. Price, G. Bottomley
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 302:390-396
Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by inflammatory cells, has been implicated in several inflammatory disease states. (E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-2'-(methanesulfonyl)-4-methylvalerohydra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94610cf6850a7c5804284eb8fb72c02e
https://doi.org/10.1124/jpet.302.1.390
https://doi.org/10.1124/jpet.302.1.390
Autor:
Michael J. Broadhurst, Andrew J. Clark, Joanne L. Peacock, Divya Patel, Yassair S. S. Al-Faiyz
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1117-1127
Activated N-alkyl-O-acyl hydroxamic acid derivatives 21a–t undergo thermal and base catalysed rearrangement to give 2-acyloxyamides 22a–t in good to excellent yields (50–100%). A range of inorganic and organic bases were screened for their effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd651ab85a85444316a46b889201a68
https://doi.org/10.1039/a909903d
https://doi.org/10.1039/a909903d
Publikováno v:
Tetrahedron Letters. 38:6301-6304
α-Amino acid aminyl radicals have been generated from sulfenamide precursors using Bu3SnH. The aminyl radicals undergo 5-exo-trig cyclisation reactions onto suitably placed N-alkenyl or α-alkenyl chains on the amino acids with reasonable diastereos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f165c83d255128b0d8282c6793338089
https://doi.org/10.1016/s0040-4039(97)01413-5
https://doi.org/10.1016/s0040-4039(97)01413-5
Autor:
P.J. Malsher, Michael J. Broadhurst, K. M. K. Bottomley, Geoffrey Lawton, Brown Paul Anthony, M.I. Cooper, J. S. Nixon, Ian Reginald Kilford, Neera Borkakoti, William Henry Johnson, N. Ballantyne, A.J. Eatherton, B.M. Sutton, E. J. Lewis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2299-2302
A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2abba5802c7d4c274e7e5bc1f9ae53df
https://doi.org/10.1016/s0960-894x(97)00416-2
https://doi.org/10.1016/s0960-894x(97)00416-2
Publikováno v:
Tetrahedron Letters. 38:5903-5906
Whereas the lithium enolates of acetate and propionate esters of difluoroallylic alcohols fragment rapidly, even at −78 °C, methoxy- and benzyloxy-acetates form chelated enolates which undergo smooth [3,3]-rearrangement as their silyl ketene aceta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfeba76d528eca6113c016bcde287dd9
https://doi.org/10.1016/s0040-4039(97)01315-4
https://doi.org/10.1016/s0040-4039(97)01315-4
Autor:
J. Bishop, M. Brewster, J. M. Budd, David Bradshaw, F. Rose, Brown Paul Anthony, William Henry Johnson, K. M. K. Bottomley, Michael J. Broadhurst, K. Wilson, J. S. Nixon, B.M. Sutton, A. Greenham, L H Elliott, E. J. Lewis
Publikováno v:
British Journal of Pharmacology. 121:540-546
1. Ro 32-3555 (3(R)-(cyclopentylmethyl)-2(R)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (Ki values of 3.0, 4.4 and 3.4 nM, respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04ad879a10078b1561ba51fb5a1f8d7b
https://doi.org/10.1038/sj.bjp.0701150
https://doi.org/10.1038/sj.bjp.0701150
Autor:
Hans Werner Lahm, Pat Eyers, Brown Paul Anthony, Michael J. Broadhurst, L H Elliott, John M. Budd, Trevor J. Hallam, Urs Röthlisberger, David Bradshaw, Geoffrey Lawton, Amanda Whittle, J. S. Nixon, Maisie James, Hill Christopher Huw, Janet E. Merritt, Neera Borkakoti, William Henry Johnson, Balraj Krishnan Handa, K. M. K. Bottomley
Publikováno v:
Biochemical Journal. 323:483-488
N-terminal analysis of aggrecan fragments lost from bovine nasal cartilage cultured in the presence of recombinant human interleukin 1alpha revealed a predominant ARGSVIL sequence with an additional ADLEX sequence. Production of the ARGSVIL-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2481197cc0207f066b2fbffa6c53b86
https://doi.org/10.1042/bj3230483
https://doi.org/10.1042/bj3230483
Publikováno v:
Tetrahedron Letters. 42:2007-2009
The phosphazene super bases BTPP 5 , P-2- t Bu 6 , and P-4- t Bu 7 mediate the rearrangement of unactivated N -alkyl- O -benzoyl hydroxamic acid derivatives 8 , 11a – f , 13 and 16 to give 2-benzoyloxy amides 9 , 12a – f , 14 and 17 . The rate of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85fdc93de2ad619e047cb57939ce86a5
https://doi.org/10.1016/s0040-4039(01)00062-4
https://doi.org/10.1016/s0040-4039(01)00062-4
Autor:
Colin C. F. Blake, Hans R. Hartmann, Michael J. Broadhurst, Elizabeth Keech, David J. Bushnell, Gareth John Thomas, Cedric H. Hassall, Nigel Adams, Alan R. Stratton
Publikováno v:
ChemInform. 22
A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor activity. A series of carbamate derivatives of these (hydroxyalkyl)anthracyclines have now been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b528e30e7498387419522dad27a9bc
https://doi.org/10.1002/chin.199108332
https://doi.org/10.1002/chin.199108332
Autor:
David J. Bushnell, Hans R. Hartmann, Elizabeth Keech, Michael J. Broadhurst, Nigel Adams, Gareth John Thomas, Colin C. F. Blake, Alan R. Stratton, Cedric H. Hassall
Publikováno v:
ChemInform. 22
A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl, 9-(hydroxylalkyl), or 9-carbamoyl substituents. Silver trifluoromethanesulfonate catalyzed coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72253667830faa4509363f3eeea134e
https://doi.org/10.1002/chin.199108331
https://doi.org/10.1002/chin.199108331