Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Michael J. Bray"'
Autor:
Jessica L. Bourdon, Amelia Dorsey, Maia Zalik, Amanda Pietka, Patricia Salyer, Michael J. Bray, Laura J. Bierut, Alex T. Ramsey
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background The use of genetically-informed personalized risk information for behavioral disorders, namely smoking and smoking-related behaviors, is a promising yet understudied area. The Genetics and Smoking Risk Profile, or RiskProfile, lev
Externí odkaz:
https://doaj.org/article/98c58c62e85f43a4b42fa24ed8ec6330
Autor:
Bryan C. Quach, Michael J. Bray, Nathan C. Gaddis, Mengzhen Liu, Teemu Palviainen, Camelia C. Minica, Stephanie Zellers, Richard Sherva, Fazil Aliev, Michael Nothnagel, Kendra A. Young, Jesse A. Marks, Hannah Young, Megan U. Carnes, Yuelong Guo, Alex Waldrop, Nancy Y. A. Sey, Maria T. Landi, Daniel W. McNeil, Dmitriy Drichel, Lindsay A. Farrer, Christina A. Markunas, Jacqueline M. Vink, Jouke-Jan Hottenga, William G. Iacono, Henry R. Kranzler, Nancy L. Saccone, Michael C. Neale, Pamela Madden, Marcella Rietschel, Mary L. Marazita, Matthew McGue, Hyejung Won, Georg Winterer, Richard Grucza, Danielle M. Dick, Joel Gelernter, Neil E. Caporaso, Timothy B. Baker, Dorret I. Boomsma, Jaakko Kaprio, John E. Hokanson, Scott Vrieze, Laura J. Bierut, Eric O. Johnson, Dana B. Hancock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.
Externí odkaz:
https://doaj.org/article/508c732e509b4270b0f67aeb1af54d38
Autor:
Todd L. Edwards, Ayush Giri, Jacklyn N. Hellwege, Katherine E. Hartmann, Elizabeth A. Stewart, Janina M. Jeff, Michael J. Bray, Sarah A. Pendergrass, Eric S. Torstenson, Jacob M. Keaton, Sarah H. Jones, Radhika P. Gogoi, Helena Kuivaniemi, Kathryn L. Jackson, Abel N. Kho, Iftikhar J. Kullo, Catherine A. McCarty, Hae Kyung Im, Jennifer A. Pacheco, Jyotishman Pathak, Marc S. Williams, Gerard Tromp, Eimear E. Kenny, Peggy L. Peissig, Joshua C. Denny, Dan M. Roden, Digna R. Velez Edwards
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Uterine fibroids affect up to 77% of women by menopause and account for up to $34 billion in healthcare costs each year. Although fibroid risk is heritable, genetic risk for fibroids is not well understood. We conducted a two-stage case-control meta-
Externí odkaz:
https://doaj.org/article/31264c40f47649e09523e49d087a56fb
Autor:
Patricia Salyer, Laura J. Bierut, Penina Acayo Laker, Alex T. Ramsey, Amelia Dorsey, Maia Zalik, Michael J. Bray, Jessica L. Bourdon, Erika A. Waters, Amanda Pietka, Li-Shiun Chen
Publikováno v:
Cancer Prev Res (Phila)
Despite major advancements in genomic medicine, research to optimize the design and communication of genetically informed interventions in behavioral health has lagged. The goal of this study was to engage potential end users in participatory codesig
Autor:
Eric S. Torstenson, Lea K. Davis, Sarah H. Jones, Digna R. Velez Edwards, Todd L. Edwards, Michael J. Bray
Publikováno v:
Hum Hered
Background: Heritability estimates (including twin and single nucleotide polymorphism [SNP]-based heritability studies) for fibroids have been inconsistent across prior studies ranging between 9 and 69%. These inconsistencies are due to variations in
Autor:
Peter B. Barr, Schahram Akbarian, Erich J. Baker, Yuan Zhou, Jason Ernst, Emma C. Johnson, Qing Lu, Li Shen, Bryan C. Quach, Daniel Jacobson, David O Walton, Apurva S. Chitre, Christian Fischer, Dongbing Lai, Arpana Agrawal, Desmond J. Smith, Vivek M. Philip, Eric J. Nestler, Laura J. Bierut, Chelsie E. Benca-Bachman, Manav Kapoor, Hyejung Won, Michael J. Bray, Soo Bin Kwon, Robert W. Williams, Molly A. Bogue, Laura Saba, Thorgeir E. Thorgeirsson, Rohan H. C. Palmer, Michael F. Miles, Clarissa C. Parker, Pjotr Prins, Sandra Sanchez-Roige, Anita Bandrowski, Hao Chen, Joel Gelernter, Dana B. Hancock, Shan Zhang, Eric O. Johnson, Elissa J. Chesler, Howard J. Edenberg, Spencer Mahaffey, Jake Emerson, Timothy Reynolds, Renato Polimanti, Abraham A. Palmer, Anurag Verma, Nathan C. Gaddis, Michael Hawrylycz, Maryann E. Martone
Publikováno v:
Genes, brain, and behavior, vol 20, iss 6
Genes, Brain, and Behavior
Genes, Brain, and Behavior
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f1ca6744de16af819b05aea185729d
https://escholarship.org/uc/item/824438bw
https://escholarship.org/uc/item/824438bw
Autor:
Yinjiao Ma, Laura J. Bierut, Michael J. Bray, Nancy L. Saccone, Richard A. Grucza, Timothy B. Baker, Eric O. Johnson, James McKay, Louis Fox, Li-Shiun Chen, Sarah M. Hartz, Robert Culverhouse, Dana B. Hancock
Publikováno v:
Nicotine Tob Res
Introduction The purpose of this study is to examine the predictive utility of polygenic risk scores (PRSs) for smoking behaviors. Aims and Methods Using summary statistics from the Sequencing Consortium of Alcohol and Nicotine use consortium, we gen
Autor:
Michael J. Bray, Amanda Pietka, Amelia Dorsey, Maia Zalik, Laura J. Bierut, Jessica L. Bourdon, Timothy B. Baker, Marcus R. Munafò, Li-Shiun Chen, Patricia Salyer, Alex T. Ramsey
Publikováno v:
Cancer Prev Res (Phila)
Ramsey, A T, Bourdon, J L, Bray, M, Dorsey, A, Zalik, M, Pietka, A, Salyer, P, Chen, L-S, Baker, T B, Munafo, M R & Bierut, L J 2020, ' Proof of concept of a personalized genetic risk tool to promote smoking cessation : High acceptability and reduced cigarette smoking ', Cancer Prevention Research, vol. 14, no. 2, pp. 253-262 . https://doi.org/10.1158/1940-6207.CAPR-20-0328
Ramsey, A T, Bourdon, J L, Bray, M, Dorsey, A, Zalik, M, Pietka, A, Salyer, P, Chen, L-S, Baker, T B, Munafo, M R & Bierut, L J 2020, ' Proof of concept of a personalized genetic risk tool to promote smoking cessation : High acceptability and reduced cigarette smoking ', Cancer Prevention Research, vol. 14, no. 2, pp. 253-262 . https://doi.org/10.1158/1940-6207.CAPR-20-0328
Relatively little is known about the possible effects of personalized genetic risk information on smoking, the leading preventable cause of morbidity and mortality. We examined the acceptability and potential behavior change associated with a persona
Autor:
Rachel F. Tyndale, Mengzhen Liu, Laura J. Bierut, Robert Culverhouse, Louis Fox, Timothy B. Baker, James McKay, Li-Shiun Chen, Scott I. Vrieze, Dana B. Hancock, John E. Hokanson, Nancy L. Saccone, Eric O. Johnson, Michael J. Bray, Sarah M. Hartz
Publikováno v:
Genet Epidemiol
Smoking is a major contributor to lung cancer and chronic obstructive pulmonary disease (COPD). Two of the strongest genetic associations of smoking-related phenotypes are the chromosomal regions 15q25.1, encompassing the nicotinic acetylcholine rece
Autor:
Marcella Rietschel, Henry R. Kranzler, Bryan C. Quach, Jouke-Jan Hottenga, William G. Iacono, Lindsay A. Farrer, Joel Gelernter, Georg Winterer, Dorret I. Boomsma, Jacqueline M. Vink, Maria Teresa Landi, Fazil Aliev, Matt McGue, Dana B. Hancock, Danielle M. Dick, Michael C. Neale, Scott I. Vrieze, Kendra A. Young, Nancy L. Saccone, Michael Nothnagel, Mengzhen Liu, Neil E. Caporaso, Timothy B. Baker, Nathan C. Gaddis, Richard Sherva, Laura J. Bierut, Mary L. Marazita, Richard A. Grucza, Yuelong Guo, Pamela A. F. Madden, Nancy Y A Sey, Camelia C. Minică, Stephanie Zellers, Alex Waldrop, Eric O. Johnson, Hannah Young, Daniel W. McNeil, Hyejung Won, Jesse Marks, John E. Hokanson, Jaakko Kaprio, Michael J. Bray, Teemu Palviainen, Christina A. Markunas
Cigarette smoking is the leading cause of preventable morbidity and mortality. Knowledge is evolving on genetics underlying initiation, regular smoking, nicotine dependence (ND), and cessation. We performed a genome-wide association study using the F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e7fb1cd3c7579f0ac57cdf663daddb