Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael J. Boucher"'
Autor:
Michael J. Boucher, Ellen Yeh
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Malaria parasites (Plasmodium spp.) contain a nonphotosynthetic plastid organelle called the apicoplast, which houses essential metabolic pathways and is required throughout the parasite life cycle. The biogenesis pathways responsible for ap
Externí odkaz:
https://doaj.org/article/6495b587a66f43b79dc0362445838590
Autor:
Michael J Boucher, Sreejoyee Ghosh, Lichao Zhang, Avantika Lal, Se Won Jang, An Ju, Shuying Zhang, Xinzi Wang, Stuart A Ralph, James Zou, Joshua E Elias, Ellen Yeh
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2005895 (2018)
Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary eukaryote-eukaryote endosymbiosis, the apicoplast is a fascinating organelle whose fun
Externí odkaz:
https://doaj.org/article/d925f6a77f2445a2baa9c3bf5bedc363
Autor:
Marcin Drąg, Jiří Brynda, Robin Kryštůfek, Jan Konvalinka, Eva Tloušt’ová, Martin Hradilek, Michael J. Boucher, Pavel Šácha, Justyna Grzymska, Pavlína Řezáčová, Miroslav Hájek, Jana Starková, Wioletta Rut, Charles S. Craik, Hiten D. Madhani, Pavel Majer
Publikováno v:
Journal of medicinal chemistry, vol 64, iss 10
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Cryptococcosis is an invasive infection that accounts for 15% of AIDS-related fatalities. Still, treating cryptococcosis remains a significant challenge due to the poor availability of effective antifungal therapies and emergence of drug resistance.
Autor:
Elizabeth A. Gaylord, Michael J. Boucher, Meenakshi B. Joshi, Manning Y. Huang, Liza C. Loza, Tamara L. Doering, Hiten D. Madhani, Sujin Lee
Publikováno v:
Genetics
Cryptococcus neoformans, the most common cause of fungal meningitis, is a basidiomycete haploid budding yeast with a complete sexual cycle. Genome modification by homologous recombination is feasible using biolistic transformation and long homology a
Publikováno v:
Molecular Biology of the Cell
Trypanosoma brucei has a unique catenated mitochondrial DNA (mtDNA) network called kinetoplast DNA (kDNA). Replication of kDNA occurs once per cell cycle in near synchrony with nuclear S phase and requires the coordination of many proteins. Among the
Autor:
Nina F. Gnädig, Jonathan Z. Long, Yani Zhou, Ouma Onguka, Eranthie Weerapana, David A. Fidock, Barbara H. Stokes, Sachel Mok, Anne-Catrin Uhlemann, Stephanie M. Terrell, Kenji L. Kurita, Piotr Cieplak, Christopher J. Schulze, Tomas Yeo, Roger G. Linington, Ian T. Foe, Matthew Bogyo, Michael J. Boucher, Euna Yoo
SUMMARYSalinipostin A (Sal A) is a potent antimalarial marine natural product with an undefined mechanism of action. Using a Sal A-derived activity-based probe, we identify its targets in thePlasmodium falciparumparasite. All of the identified protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213079f81ffedc83bc3c52eeab1a4ac0
Autor:
David A. Fidock, Barbara H. Stokes, Piotr Cieplak, Yani Zhou, Krittikorn Kümpornsin, Sachel Mok, Jonathan Z. Long, Euna Yoo, Kenji L. Kurita, Ian T. Foe, Matthew Bogyo, Michael J. Boucher, Nina F. Gnädig, Anne-Catrin Uhlemann, Ouma Onguka, Tomas Yeo, Roger G. Linington, Stephanie M. Terrell, Christopher J. Schulze, Marcus C. S. Lee, Eranthie Weerapana
Publikováno v:
Cell Chem Biol
Summary Salinipostin A (Sal A) is a potent antiplasmodial marine natural product with an undefined mechanism of action. Using a Sal A-derived activity-based probe, we identify its targets in the Plasmodium falciparum parasite. All of the identified p
Autor:
Jonathan C. Miller, Jeniffer Concepción-Acevedo, Michael J. Boucher, Stephanie B. Delzell, Michele M. Klingbeil
Publikováno v:
J Cell Sci
Mitochondrial DNA of Trypanosoma brucei and related parasites is a catenated network containing thousands of minicircles and tens of maxicircles, called kinetoplast DNA (kDNA). Replication of a single nucleoid requires at least three DNA polymerase I
Autor:
Ellen Yeh, Michael J. Boucher
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 6, p e1007661 (2019)
PLoS Pathogens, Vol 15, Iss 6, p e1007661 (2019)
Autor:
Eranthie Weerapana, Nina F. Gnädig, Barbara H. Stokes, Ian T. Foe, Kenji L. Kurita, Roger G. Linington, Anne-Catrin Uhlemann, Matthew Bogyo, Michael J. Boucher, Jonathan Z. Long, Piotr Cieplak, David A. Fidock, Ouma Onguka, Euna Yoo, Tomas Yeo, Yani Zhou, Christopher J. Schulze, Sachel Mok, Stephanie M. Terrell
Publikováno v:
SSRN Electronic Journal.
Salinipostin A (Sal A) is a potent antimalarial marine natural product with an undefined mechanism of action. Using a Sal A-derived activity-based probe, we identify its targets in the Plasmodium falciparum parasite. All of the identified proteins co