Výsledky vyhledávání - "Michael J. Ashby"

Inducible nitric oxide synthase activity is increased in patients with rheumatoid arthritis and contributes to endothelial dysfunction

Autor: Kaisa M. Mäki-Petäjä, Carmel M. McEniery, Frances Hall, Joseph Cheriyan, Sharon M.L. Wallace, John Brown, A. D. Booth, Ian B. Wilkinson, Michael J. Ashby

Publikováno v: International Journal of Cardiology. 129:399-405

Recent in vitro studies suggest that inducible nitric oxide synthase (iNOS) activity mediates endothelial dysfunction. Rheumatoid arthritis (RA) is a chronic inflammatory condition and is associated with endothelial dysfunction and increased risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b4307e3557b94d5d350a5bb8251611
https://doi.org/10.1016/j.ijcard.2008.02.011

Zobrazit plný text záznamu

The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio

Autor: Michael J. Ashby, Morris J. Brown, Susan J. Hood, Kevin Taylor

Publikováno v: Circulation. 116:268-275

Background— There is continuing variation in diagnosis and estimated prevalence of primary hyperaldosteronism. The higher estimates encourage search for adrenal adenomas in patients with elevated ratios of plasma aldosterone to renin. However, it i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1171dcf9b148a79abd8221740359d3e9
https://doi.org/10.1161/circulationaha.107.690396

Zobrazit plný text záznamu

Characterization of [125 I]-PD164333, an ETA selective non-peptide radiolabelled antagonist, in normal and diseased human tissues

Autor: Annette Marian Doherty, William C. Patt, Michael J. Ashby, Anthony P. Davenport, Rhoda E. Kuc

Publikováno v: British Journal of Pharmacology. 123:223-230

We have synthesized a new low molecular weight, non-peptide radioligand, [125I]-PD164333, an analogue of the orally active butenolide antagonists of the endothelin ETA receptor. Analysis of saturation binding assays demonstrated that [125I]-PD164333

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53607bab34e1959629cc61fe6ab7d3ad
https://doi.org/10.1038/sj.bjp.0701597

Zobrazit plný text záznamu

Bilateral adrenal masses: phaeochromocytoma or melanoma?

Autor: Isla S. Mackenzie, Morris J. Brown, Demetrius D Voutnis, Michael J. Ashby, Tim Donovan

Publikováno v: Journal of the Royal Society of Medicine. 99:153-155

Adrenal masses vary in importance from being incidental findings of no clinical significance to having sinister consequences through malignancy. The importance in integrating the clinical history, biochemical findings and results of modern imaging te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22258b85bf8651c4c57edc7bbdb3c03d
https://doi.org/10.1258/jrsm.99.3.153

Zobrazit plný text záznamu

Expression of Endothelin Peptides and Mrna in the Human Heart

Autor: Rhoda E. Kuc, G O'Reilly, Anthony P. Davenport, Michael J. Ashby, Christopher Plumpton

Publikováno v: Europe PubMed Central

1. We have examined the expression of endothelin isoforms and their precursors in the human heart using RIA, HPLC, immunocytochemistry and reverse transcriptase—polymerase chain reaction assays. 2. Highly specific RIAs were used to measure the leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008e92f33fe9991f26166d49025bcaec
https://doi.org/10.1042/cs0900037

Zobrazit plný text záznamu

Response to Letter Regarding Article, 'The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio'

Autor: Michael J. Ashby, Kevin Taylor, Morris J. Brown, Susan J. Hood

Publikováno v: Circulation. 117

We thank Dr Mulatero and colleagues for their comments on the importance of the Spironolactone, Amiloride, Losartan, and Thiazide (SALT) trial, although the question of whether K+-sparing diuretics protect against glucose intolerance is only now bein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3a447d876e92491e6197c2ceecb0849
https://doi.org/10.1161/circulationaha.107.744250

Zobrazit plný text záznamu

AT2 receptor stimulation may halt progression of pheochromocytoma

Autor: Derek S. Appleton, Michael J. Ashby, Isla S. Mackenzie, Morris J. Brown, Kottekkattu K. Balan

Publikováno v: Annals of the New York Academy of Sciences. 1073

Two patients with pheochromocytoma are described in whom treatment with a high dose of an angiotensin receptor blocker was associated with cessation of tumor growth as assessed by serial CT scanning and plasma norepinephrine estimation. If the associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab613197eb991841438fe58d047d29ff
https://pubmed.ncbi.nlm.nih.gov/17102112

Zobrazit plný text záznamu

Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals

Autor: Ian B. Wilkinson, Carmel M. McEniery, Michael J. Ashby, Patrick Harnett, Yasmin, John R. Cockcroft, Barry J. McDonnell, Kaisa M. Mäki-Petäjä, John Brown, Kevin M. O'Shaughnessy, Asif Arshad, Sharon M.L. Wallace

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 26(8)

Background— Arterial stiffness is an important determinant of cardiovascular risk. Elastin is the main elastic component of the arterial wall and can be degraded by a number of enzymes including serine proteases and matrix metalloproteinases (MMPs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25350fa03491db74b3e180f3baa88cc4
https://pubmed.ncbi.nlm.nih.gov/16709939

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání