Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael J. Abrahamson"'
Autor:
Ryan M. Phelan, Michael J. Abrahamson, Jesse T. C. Brown, Ruijie K. Zhang, Christian R. Zwick
Publikováno v:
Organic Process Research & Development. 26:1944-1959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c800739f89685c97952a7084acd46048
https://doi.org/10.1021/acs.oprd.1c00467
https://doi.org/10.1021/acs.oprd.1c00467
Autor:
Rodger F. Henry, Chen Ding, Sanjay R. Chemburkar, Shuang Chen, Hongqiang Zhang, Nandkishor K. Nere, Jianzhang Mei, Kirill A. Lukin, Rajarathnam E. Reddy, David R. Hill, Matthew J. Pelc, Angelica B. Kielbus, Timothy B. Towne, Michael J. Abrahamson, Kenneth M. Engstrom, Russell D. Cink
Publikováno v:
Organic Process Research & Development. 24:1393-1404
The preceding article described the development of the large-scale synthetic route to macrocycle 3 of glecaprevir (1), a potent HCV protease inhibitor. This article describes the development of the...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::282f605e761bed3756f3a1fb8d0587d2
https://doi.org/10.1021/acs.oprd.0c00245
https://doi.org/10.1021/acs.oprd.0c00245
Publikováno v:
Advanced Synthesis & Catalysis. 355:1780-1786
The reductive amination of ketones to produce chiral amines is an important transformation in the production of pharmaceutical intermediates. Therefore, industrially applicable enzymatic methods that enable the selective synthesis of chiral amines co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7a0ec416f8cacfdea760dafe04181dd
https://doi.org/10.1002/adsc.201201030
https://doi.org/10.1002/adsc.201201030
Autor:
Nicholas B. Woodall, Andreas S. Bommarius, Eduardo Vazquez-Figueroa, Jeffrey C. Moore, Michael J. Abrahamson
Publikováno v:
Angewandte Chemie International Edition. 51:3969-3972
A leucine dehydrogenase has been successfully altered through several rounds of protein engineering to an enantioselective amine dehydrogenase. Instead of the wild-type α-keto acid, the new amine dehydrogenase now accepts the analogous ketone, methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da402f69bcef6be5d7bbaf3e490ebde
https://doi.org/10.1002/anie.201107813
https://doi.org/10.1002/anie.201107813
Autor:
Nicholas B. Woodall, Michael J. Abrahamson, Andreas S. Bommarius, Eduardo Vazquez-Figueroa, Jeffrey C. Moore
Publikováno v:
Angewandte Chemie. 124:4036-4040
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::143901417d747ae15a6309c61aefbc16
https://doi.org/10.1002/ange.201107813
https://doi.org/10.1002/ange.201107813
Publikováno v:
Current Opinion in Chemical Biology. 15:194-200
Recent advances in the development of both experimental and computational protein engineering tools have enabled a number of further successes in the development of biocatalysts ready for large-scale applications. Key tools are first, the targeting o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c99471b9a2799b7c8a0729e36d38a7
https://doi.org/10.1016/j.cbpa.2010.11.011
https://doi.org/10.1016/j.cbpa.2010.11.011
Autor:
Bettina Bommarius, Andreas S. Bommarius, Samantha K. Au, Michael J. Abrahamson, Martin Schuermann
Publikováno v:
The FASEB Journal. 28
Recently, we obtained the first amine dehydrogenases, termed L-AmDH and F-AmDH, from leucine DH [1] and phenylalanine DH [2], respectively, allowing direct reductive amination of ketones to chiral amines. Starting from a scaffold devoid of such activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4398ad31272839625abce13d424ac08
https://doi.org/10.1096/fasebj.28.1_supplement.363.3
https://doi.org/10.1096/fasebj.28.1_supplement.363.3
Publikováno v:
Journal of colloid and interface science. 315(1)
Approximately 90% of all ophthalmic drug formulations are now applied as eye-drops. While eye-drops are convenient and well accepted by patients, about 95% of the drug contained in the drops is lost due to absorption through the conjunctiva or throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43da4dcbe7d3ebdceb15c1f53ea228b
https://pubmed.ncbi.nlm.nih.gov/17673246
https://pubmed.ncbi.nlm.nih.gov/17673246