Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michael J. Abbott"'
Autor:
Martine Keenan, Eileen Ryan, Scott Cornwall, Andrea Khong, Jason H. Chaplin, Wayne M. Best, Karen L. White, R.C. Andrew Thompson, Catherine J. Perez, Ivan Scandale, Susan A. Charman, Michael J. Abbott, Paul W. Alexander, Francis C. K. Chiu, David M. Shackleford, Michael Campbell, Maria Koltun, Eric Chatelain, Adriana Botero, Julia Morizzi, Thomas W. von Geldern
Publikováno v:
Journal of Medicinal Chemistry
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is an increasing threat to global health. Available medicines were introduced over 40 years ago, have undesirable side effects, and give equivocal results of cure in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38832ff07aa1233c73b2095f1457b219
https://doi.org/10.1021/jm401610c
https://doi.org/10.1021/jm401610c
Autor:
Martine Keenan, Eileen Ryan, Susan A. Charman, Jason H. Chaplin, Karen L. White, Eric Chatelain, Gong Chen, Jean-Robert Ioset, Zhisen Wang, Michael J. Abbott, Scott Cornwall, Wayne M. Best, Sarah Keatley, Paul W. Alexander, Thomas W. von Geldern, Hugo Diao, Catherine J. Perez, R.C. Andrew Thompson
Publikováno v:
Future Medicinal Chemistry. 5:1733-1752
Background: Inhibitors of Trypanosoma cruzi with novel mechanisms of action are urgently required to diversify the current clinical and preclinical pipelines. Increasing the number and diversity of hits available for assessment at the beginning of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de70cd8bb075d45ff1f1bb4e212c14b
https://doi.org/10.4155/fmc.13.139
https://doi.org/10.4155/fmc.13.139
Autor:
Tanya Armstrong, Thomas W. von Geldern, Sen Z. Wang, Bradley Berven, Michael J. Abbott, Ivan Scandale, Susan A. Charman, Jason H. Chaplin, Andrea Khong, Joshua D. McManus, Eric Chatelain, Adriana Botero, Wayne M. Best, Julia Morizzi, Maria Kerfoot, Tien Nguyen, Paul W. Alexander, Karen L. White, R.C. Andrew Thompson, Martine Keenan, Eileen Ryan
Publikováno v:
Journal of Medicinal Chemistry. 55:4189-4204
We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi ( T. cruzi ), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC(50)s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a30d423509261689188e5175fe646b
https://doi.org/10.1021/jm2015809
https://doi.org/10.1021/jm2015809
Effects of Dietary Energy and Protein Restriction on Nutritional Indices of Female White-Tailed Deer
Publikováno v:
The Journal of Wildlife Management. 59:595
Several physical and physiological indices have been used to assess white-tailed deer (Odocoileus virginianus) nutritional condition and habitat quality. We tested whether indices reflected inferred nutritional circumstances under controlled conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::193ae92ea524809fb90f654d059fc37c
https://doi.org/10.2307/3802468
https://doi.org/10.2307/3802468
Autor:
Stephen M. Schmitt, Duane E. Ullrey, H. Allen Tucker, Michael J. Abbott, Pao K. Ku, Dale R. Romsos
Publikováno v:
The Journal of Wildlife Management. 48:776
The effects of contrasting (16L:8D vs. 8L:16D) photoperiods on fat accretion and growth in 19 white-tailed doe fawns (Odocoileus virginianus) from 9 September to 16 December 1981 were examined. Fawns exposed to long days (LD fawns) delayed their autu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d27d732d2152bbde85bb0ee708d3bb7b
https://doi.org/10.2307/3801424
https://doi.org/10.2307/3801424