Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Michael J. Willhauck"'
Autor:
Geoffrey K Grünwald, Alexandra Vetter, Kathrin Klutz, Michael J Willhauck, Nathalie Schwenk, Reingard Senekowitsch-Schmidtke, Markus Schwaiger, Christian Zach, Ernst Wagner, Burkhard Göke, Per S Holm, Manfred Ogris, Christine Spitzweg
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) gene using a dendrimer-coated adenovirus. To further improve shieldi
Externí odkaz:
https://doaj.org/article/cf89ae9f89b048719d9650b6616bc415
Autor:
Markus Schwaiger, Reingard Senekowitsch-Schmidtke, Michael J. Willhauck, Burkhard Göke, Alexandra Vetter, Geoffrey K. Grünwald, Per Sonne Holm, Manfred Ogris, Kathrin Klutz, Christine Spitzweg, Ernst Wagner, Christian Zach, Nathalie Schwenk
Publikováno v:
Journal of Nuclear Medicine. 54:1450-1457
Currently, major limitations for the clinical application of adenovirus-mediated gene therapy are high prevalence of neutralizing antibodies, widespread expression of the coxsackie-adenovirus receptor (CAR), and adenovirus sequestration by the liver.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfb35f3c00dea25838054005c338942
https://doi.org/10.2967/jnumed.112.115493
https://doi.org/10.2967/jnumed.112.115493
Autor:
Nathalie Schwenk, Burkhard Göke, Christine Spitzweg, Kerstin Knoop, Ernst Wagner, Christoph Zischek, Michael J. Willhauck, Peter J. Nelson, Markus Hacker, Patrick Dolp, Christian Zach
Publikováno v:
Human Gene Therapy. 24:306-316
The tumor-homing property of mesenchymal stem cells (MSC) has lead to their use as delivery vehicles for therapeutic genes. The application of the sodium iodide symporter (NIS) as therapy gene allows noninvasive imaging of functional transgene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528a5a4d7eb610c3294637f395001f18
https://doi.org/10.1089/hum.2012.104
https://doi.org/10.1089/hum.2012.104
Autor:
Michael J. Willhauck, Burkhard Göke, Kerstin Knoop, Christine Spitzweg, Sibylle Ziegler, Ernst Wagner, Christian Zach, Reingard Senekowitsch-Schmidtke, Nathalie Wunderlich, Franz-Josef Gildehaus, Christian Dohmen, Kathrin Klutz, Manfred Ogris, Sebastian Fürst
Publikováno v:
Human Gene Therapy. 22:1563-1574
We reported the induction of tumor-selective iodide uptake and therapeutic efficacy of (131)I in a hepatocellular carcinoma (HCC) xenograft mouse model, using novel polyplexes based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3717b9272c47fbb29cc95119676a92bb
https://doi.org/10.1089/hum.2011.041
https://doi.org/10.1089/hum.2011.041
Autor:
Marie Kolokythas, Dan Draganovici, Nathalie Wunderlich, Burkhard Göke, Peter J. Nelson, Michael J. Willhauck, Guido Böning, Kerstin Knoop, Christian Zach, Christine Spitzweg, Ernst Wagner, Franz-Josef Gildehaus, Kathrin Klutz
Publikováno v:
Molecular Therapy. 19(9):1704-1713
Due to its dual role as reporter and therapy gene, the sodium iodide symporter (NIS) allows noninvasive imaging of functional NIS expression by (123)I-scintigraphy or (124)I-PET imaging before the application of a therapeutic dose of (131)I. NIS expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09752da4d6237431e135e93f125354f8
Autor:
Christine Spitzweg, Ernst Wagner, Christian Zach, Michael J. Willhauck, David Schaffert, Rudolf Haase, Reingard Senekowitsch-Schmidtke, Geoffrey K. Grünwald, Manfred Ogris, Nathalie Wunderlich, Burkhard Göke, Franz Josef Gildehaus, Kathrin Klutz
Publikováno v:
Molecular Therapy. 19:676-685
We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of radioiodine in neuroblastoma tumors after systemic nonviral polyplex-mediated sodium iodide symporter (NIS) gene delivery. In the present study, we used novel polyplex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7af307c8328b7a6baffe24f3a8de73
https://doi.org/10.1038/mt.2010.296
https://doi.org/10.1038/mt.2010.296
Autor:
Dennis J. O`Kane, Christine Spitzweg, Michael J. Willhauck, Burkhard Göke, Nathalie Wunderlich
Publikováno v:
Breast Cancer Research and Treatment. 125:377-386
The sodium iodide symporter (NIS) mediates the active iodide uptake in the thyroid gland as well as lactating breast tissue. Recently, we reported significant stimulation of all-trans retinoic acid (atRA)-induced NIS expression in the estrogen-recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cc71f85e9163dbdf6a0efe8477a183d
https://doi.org/10.1007/s10549-010-0835-x
https://doi.org/10.1007/s10549-010-0835-x
Autor:
Norbert E. Fusenig, Nicolae Mirancea, Silvia Vosseler, Margareta M. Mueller, Hans Jürgen Stark, Alessandra Pavesio, Petra Boukamp, Michael J. Willhauck
Publikováno v:
Carcinogenesis. 28:595-610
Interactions between cancer cells and the tissue microenvironment play an essential role in controlling tumor development and progression. Here, we report that stromal modulation induced by a biodegradable meshwork (Hyalograft 3D) inhibited tumor vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9e17ad045beb83c76dd187685b4209
https://doi.org/10.1093/carcin/bgl188
https://doi.org/10.1093/carcin/bgl188
Autor:
M. Schütz, Michael J. Willhauck, Neziha Cengic, John C. Morris, Christine Spitzweg, S. Unterholzner, Burkhard Göke
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:69-78
Context: The sodium iodide symporter (NIS) mediates the active iodide uptake in the thyroid gland as well as lactating breast tissue. Recently induction of functional NIS expression was reported in the estrogen receptor-positive human breast cancer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af9723cf3fcf77824508f3bc6ef4b3c
https://doi.org/10.1210/jc.2005-0779
https://doi.org/10.1210/jc.2005-0779
Autor:
K Knoop, Burkhard Goke, Michael J. Willhauck, H Zankl, M Hacker, Peter J. Nelson, Ernst Wagner, G Böning, P Dolp, C Zischek, Christine Spitzweg, N Schwenk
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee2e9015b64533da8acbd9b8863cf62b
https://doi.org/10.1055/s-0033-1336722
https://doi.org/10.1055/s-0033-1336722