Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Michael J. McPherson"'
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1040 (2024)
Src homology 3 (SH3) domains play a critical role in mediating protein–protein interactions (PPIs) involved in cell proliferation, migration, and the cytoskeleton. Despite their abundance in the human proteome, the functions and molecular interacti
Externí odkaz:
https://doaj.org/article/09656d7271eb4a709813154e06a09ec5
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Approaches for antibody discovery have seen substantial improvement and success in recent years. Yet, advancing antibodies into the clinic remains difficult because therapeutic developability concerns are challenging to predict. We developed a comput
Externí odkaz:
https://doaj.org/article/e9eca828fb774c6fa14891a2fc97fbaf
Autor:
Katarzyna Z. Haza, Heather L. Martin, Ajinkya Rao, Amy L. Turner, Sophie E. Saunders, Britta Petersen, Christian Tiede, Kevin Tipping, Anna A. Tang, Modupe Ajayi, Thomas Taylor, Maia Harvey, Keri M. Fishwick, Thomas L. Adams, Thembaninkosi G. Gaule, Chi H. Trinh, Matthew Johnson, Alexander L. Breeze, Thomas A. Edwards, Michael J. McPherson, Darren C. Tomlinson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools
Externí odkaz:
https://doaj.org/article/9fb0e318fb534431a1e30f0ac4d27ca1
Autor:
Shazana Hilda Shamsuddin, David G. Jayne, Darren C. Tomlinson, Michael J. McPherson, Paul A. Millner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Carcinoembryonic antigen (CEA) is the only blood based protein biomarker at present, used for preoperative screening of advanced colorectal cancer (CRC) patients to determine the appropriate curative treatments and post-surveillance screenin
Externí odkaz:
https://doaj.org/article/1a33adcba2a44a18b93a84d48aebf2a6
Autor:
Hope Adamson, Amanda Nicholl, Christian Tiede, Anna A Tang, Alex Davidson, Helen Curd, Alex Wignall, Robert Ford, James Nuttall, Michael J McPherson, Matt Johnson, Darren C Tomlinson
Publikováno v:
BioTechniques, Vol 67, Iss 6, Pp 261-269 (2019)
Therapeutic antibodies are the fastest growing class of drugs in the treatment of cancer, and autoimmune and inflammatory diseases that require the concomitant development of assays to monitor therapeutic antibody levels. Here, we demonstrate that th
Externí odkaz:
https://doaj.org/article/9af09924ca4c4659a73e4f3514b2de9a
Autor:
Adrian D. Hobson, Michael J. McPherson, Martin E. Hayes, Christian Goess, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Jindong Yang, Liang Sun, Qiang Zhang, Pei Qu, Shi Yang, Axel Hernandez, Shaughn H. Bryant, Suzanne L. Mathieu, Agnieszka K. Bischoff, Julia Fitzgibbons, Ling C. Santora, Lu Wang, Margaret M. Fettis, Xiaofeng Li, Christopher C. Marvin, Zhi Wang, Meena V. Patel, Diana L. Schmidt, Tongmei Li, John T. Randolph, Rodger F. Henry, Candace Graff, Yu Tian, Ana L. Aguirre, Anurupa Shrestha
Publikováno v:
Journal of Medicinal Chemistry. 65:15893-15934
Using a convergent synthetic route to enable multiple points of diversity, a series of glucocorticoid receptor modulators (GRM) were profiled for potency, selectivity, and drug-like properties
Autor:
Rhodri J. King, Katharina Schuett, Christian Tiede, Vera Jankowski, Vicky John, Abhi Trehan, Katie Simmons, Sreenivasan Ponnambalam, Robert F. Storey, Colin W.G. Fishwick, Michael J. McPherson, Darren C. Tomlinson, Ramzi A. Ajjan
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Complement C3 binds fibrinogen and compromises fibrin clot lysis thereby enhancing thrombosis risk. We investigated the role of fibrinogen-C3 interaction as a novel therapeutic target to reduce thrombosis risk by analysing: i) consistency in the fibr
Externí odkaz:
https://doaj.org/article/0a7a6073a1f94ae8b8c4a4c9e4c51308
Autor:
Raheem Ullah, Aamir Shehzad, Majid Ali Shah, Matteo De March, Fouzia Ismat, Mazhar Iqbal, Silvia Onesti, Moazur Rahman, Michael J. McPherson
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 926 (2020)
The human zinc transporter 8 (hZnT8) plays important roles in the storage of insulin in the secretory vesicles of pancreatic β cells. hZnT8 consists of a transmembrane domain, with its N- and C-termini protruding into the cytoplasm. Interestingly, t
Externí odkaz:
https://doaj.org/article/918201aae0ed440b94dff7e8287c55a4
Autor:
Oleg A. Karpov, Gareth W. Fearnley, Gina A. Smith, Jayakanth Kankanala, Michael J. McPherson, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v:
AIMS Biophysics, Vol 2, Iss 4, Pp 476-502 (2015)
Receptor tyrosine kinases (RTKs) are membrane proteins that control the flow of information through signal transduction pathways, impacting on different aspects of cell function. RTKs are characterized by a ligand-binding ectodomain, a single transme
Externí odkaz:
https://doaj.org/article/58bd594031e341e1855696de9aa98863
Autor:
Kevin W. Tipping, Thembaninkosi G. Gaule, Keri M. Fishwick, Amy L. Turner, Anna A Tang, Britta Petersen, Heather L. Martin, Sophie E. Saunders, Chi H. Trinh, Darren C. Tomlinson, Ajinkya Rao, Alexander L. Breeze, Matthew D. Johnson, Thomas A. Edwards, Thomas L. Adams, Maia Harvey, Katarzyna Z. Haza, Thomas Taylor, Michael J. McPherson, Modupe Ajayi, Christian Tiede
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
'Nature Communications ', vol: 12, pages: 4045-1-4045-15 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 4045-1-4045-15 (2021)
Nature Communications
RAS mutations are the most common oncogenic drivers across human cancers, but there remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable pockets have proven difficult to identify. Here, we identify two RAS-binding