Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Michael J. Klemsz"'
Autor:
Jingwu Xie, Michael J. Klemsz, Melissa A. Kacena, George Sandusky, Xiaoli Zhang, Mark H. Kaplan
Publikováno v:
Journal of medical virology. 94(12)
Coronavirus disease 2019 (COVID-19) is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 500 million confirmed cases of COVID-19 have been recorded, with six million deaths. Thus, reducing the COVID-19-related m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dfd2860c88dcaeb6112a38af3f3392
https://pubmed.ncbi.nlm.nih.gov/36030555
https://pubmed.ncbi.nlm.nih.gov/36030555
Autor:
Melissa A. Kacena, Edward F. Srour, Mariel Carozza, Karen Boschen, Christopher M. Robinson, Christopher E. Dalloul, Nancy A. Johnston, Angela Bruzzaniti, Ushashi C. Dadwal, Michael J. Klemsz, Rachel J. Blosser, Olatundun D. Awosanya
Publikováno v:
Bone
The consequences of SARS-CoV-2 infection on the musculoskeletal system represent a dangerous knowledge gap. Aging patients are at added risk for SARS-CoV-2 infection; therefore, a greater understanding of the resulting musculoskeletal sequelae of SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7689d98be19781a8bb278930c810
https://pubmed.ncbi.nlm.nih.gov/34607050
https://pubmed.ncbi.nlm.nih.gov/34607050
Autor:
Kevin F. Gibson, Imre Noth, Kevin R. Flaherty, Katia Rothhaar, Michael J. Klemsz, Sarah Frye, Terrence Chew, Naftali Kaminski, Wade Lange, David S. Wilkes
Publikováno v:
European Respiratory Journal. 45:1393-1402
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. IPF appears to be heterogeneous in pathobiology with ∼40% of IPF patients found to have elevated levels of circulating antibodies to the autoantigen type V colla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc936a981a5640c26972284f47ff0e72
https://doi.org/10.1183/09031936.00105314
https://doi.org/10.1183/09031936.00105314
Autor:
Michael J. Klemsz, Brandon A. Mann, Roger B. Slee, Mark H. Kaplan, Julia H. Huang, Audrey O’Sullivan, Mathur Anita, Ping Li, Hua-Chen Chang, Randy R. Brutkiewicz, Janice S. Blum, Norman Yeh
Publikováno v:
Journal of Interferon & Cytokine Research. 28:367-380
Blocking the function of Stat (signal transducer and activator of transcription) proteins, which are critical for antiviral responses, has evolved as a common mechanism for pathogen immune evasion. The poxvirus-encoded phosphatase H1 is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8606012077214cfadbfb4abb8e99c237
https://doi.org/10.1089/jir.2007.0113
https://doi.org/10.1089/jir.2007.0113
Publikováno v:
Virology. 329:189-198
Histone acetylation plays an important role in chromatin remodeling and transcription control. Acetylation of histones is regulated by histone acetyltransferases and histone deacetylases (HDACs). Human papillomavirus type 16 (HPV16) E7 can inactivate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cce06ee5bf208fc51b1a1b5835d3b98
https://doi.org/10.1016/j.virol.2004.08.009
https://doi.org/10.1016/j.virol.2004.08.009
Autor:
Alicia Cecil, Michael J. Klemsz
Publikováno v:
Journal of Leukocyte Biology. 75:560-568
Although interferon-γ (IFN-γ) induces the transporter associated with antigen processing (Tap)-1 expression in macrophages, cooperation with lipopolysaccharide signaling through Toll-like receptor 4 (TLR4) accelerates the kinetics and increases the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9051dfdae342344399487f84960be6ba
https://doi.org/10.1189/jlb.0803375
https://doi.org/10.1189/jlb.0803375
Autor:
Stacy L. Throm, Michael J. Klemsz
Publikováno v:
Journal of Leukocyte Biology. 74:111-117
Based on knockout models, the transcription factor PU.1 has been shown to be important for the maturation of neutrophils. As the list of genes PU.1 directly regulates in neutrophils is still quite limited, defining PU.1 target genes for this lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232330217e78684823d22f7d4f6a7846
https://doi.org/10.1189/jlb.0203061
https://doi.org/10.1189/jlb.0203061
Publikováno v:
The Journal of Immunology. 165:3190-3197
Proper regulation of the Tap-1 gene is critical for the initiation and continuation of a cellular immune response. Analysis of the Tap-1/low molecular mass polypeptide 2 bidirectional promoter showed that the IFN-γ activation site element is critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b41c13d5ba495272f785e8678e9999
https://doi.org/10.4049/jimmunol.165.6.3190
https://doi.org/10.4049/jimmunol.165.6.3190
Autor:
Michael J. Klemsz, Lakshmi Amaravadi
Publikováno v:
DNA and Cell Biology. 18:875-884
Knockout studies have shown that PU.1 is required for the normal development of many blood cell lineages, yet overexpression of this transcription factor in erythroid cells can lead to erythroleukemia. Thus, how the tissue-specific expression of PU.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1d94edc84fd2b80f29b6ed935f7811
https://doi.org/10.1089/104454999314737
https://doi.org/10.1089/104454999314737
Autor:
Richard A. Maki, Robert G. Oshima, Hideyuki Yamamoto, Michael J. Klemsz, Akihiro Umezawa, Katherine Rhodes
Publikováno v:
Molecular and Cellular Biology. 17:4885-4894
The activities of ETS transcription factors are modulated by posttranscriptional modifications and cooperation with other proteins. Another factor which could alter the regulation of genes by ETS transcription factors is DNA methylation of their cogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450d142c7a998469a7ad6994812bc398
https://doi.org/10.1128/mcb.17.9.4885
https://doi.org/10.1128/mcb.17.9.4885