Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Michael J. Hemmer"'
Publikováno v:
Integrated Environmental Assessment and Management. 9:610-615
Determining the sensitivity of a diversity of species to spilled oil and chemically dispersed oil continues to be a significant challenge in spill response and impact assessment. We used standardized tests from the literature to develop species sensi
Autor:
Kimberly A. Salinas, John W. Fournie, Becky L. Hemmer, Michael J. Hemmer, Geraldine M. Cripe, Larry R. Goodman, Calvin C. Walker
Publikováno v:
Aquatic Toxicology. 88:128-136
Protein profiling can be used for detection of biomarkers that can be applied diagnostically to screen chemicals for endocrine modifying activity. In previous studies, mass spectral analysis revealed four peptides (2950.5, 2972.5, 3003.4, 3025.5m/z)
Publikováno v:
Journal of Experimental Zoology Part A: Comparative Experimental Biology. :707-719
Gene arrays provide a powerful method to examine changes in gene expression in fish due to chemical exposures in the environment. In this study, we expanded an existing gene array for sheepshead minnows (Cyprinodon variegatus) (SHM) and used it to ex
Publikováno v:
Marine Environmental Research. 58:547-551
Several genes normally induced by estradiol (E2) in female fish, those for vitellogenins (VTGs) and zona radiata proteins (ZRPs), are also inducible in males exposed to estrogenic chemicals. Male sheepshead minnows (SHM) were exposed to both E2 and p
Autor:
Michael J. Hemmer, Christopher J. Bowman, H.Stephen Lee, Leroy C. Folmar, Nancy D. Denslow, Ronald J. Ferguson
Publikováno v:
General and Comparative Endocrinology. 121:250-260
The recent interest in hormonally active environmental contaminants has sparked a drive to find sensitive methods to measure their effects on wildlife. A molecular-based assay has been developed to measure the induction of gene expression in sheepshe
Autor:
Becky L. Hemmer, Kevin J. Kroll, Marilynn D. Hoglund, Leroy C. Folmar, Christopher J. Bowman, Michael J. Hemmer, Dragoslav T. Marcovich, Nancy D. Denslow
Publikováno v:
Environmental Toxicology and Chemistry. 20:336-343
Temporal and dose-response relationships of vitellogenin (VTG) mRNA induction and subsequent plasma VTG accumulation were established for sheepshead minnows (Cyprinodon variegatus) treated with p-nonylphenol (an alkylphenol) and the organochlorine pe
Publikováno v:
General and Comparative Endocrinology. 120:300-313
Many environmentally persistent xenobiotic chemicals appear to disrupt normal endocrine function by acting as ligands for endogenous steroid receptors, including the estrogen receptor. Xenobiotics that bind to the estrogen receptor may elicit several
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 60:275-289
Previously it was demonstrated that biliary excretion of a single dose of [14C]dieldrin or [3H]7,12-dimethylbenz[a]anthracene (DMBA) was stimulated up to 700% and 300%, respectively, in rainbow trout fed 0.3?0.4 mg dieldrin/kg/d for 9?12 wk. This was
Autor:
R Hemmer, Christopher J. Bowman, Michael J. Hemmer, Kevin J. Kroll, Nancy D. Denslow, Leroy C. Folmar
Publikováno v:
Aquatic Toxicology. 49:77-88
An in vivo bioasssay for vitellogenin (VTG) synthesis was developed to screen individual chemicals or mixtures of chemicals for potentially estrogenic effects in a marine teleost model. An enzyme-linked immunosorbent assay (ELISA) was used to quantit
Publikováno v:
The Journal of Experimental Zoology. 281:251-259
Mammalian P-glycoprotein is a highly conserved integral membrane protein functioning as an energy-dependent efflux pump which decreases the concentration of certain lipophilic aromatic compounds entering the cell by diffusion. Expression of such a tr