Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Michael J. Derelanko"'
Autor:
Michael J. Derelanko
The third edition of the Toxicologist's Pocket Handbook, like the first two editions, is a scaled-down version of the best-selling Handbook of Toxicology. It provides the most frequently used toxicology reference information in a convenient pocket-si
Autor:
Guo-Hua Chu, William M. Barker, Rolf T. Windh, Patrick J. Little, Michael J. Derelanko, Bertrand Le Bourdonnec, Michael Koblish, Diane L. DeHaven-Hudkins, Minghua Gu, Thomas M. Graczyk, Daniel D. Wiant, Lara K. Leister, Bernice L. Brogdon, Robert N. DeHaven, Christopher W. Ajello, Steven A. Smith, Serge Belanger, David D. Christ, Paul A. Tuthill, Steve Kutz, Joel A. Cassel, Marina S. Feschenko, Roland E. Dolle
Publikováno v:
Journal of Medicinal Chemistry. 51:5893-5896
Selective delta opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening. Subsequent lead optimization iden
Autor:
Michael J. Derelanko, Carol S. Auletta
The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their
Publikováno v:
Drug and Chemical Toxicology. 26:147-168
The developmental toxicity of methyl ethyl ketoxime (MEKO), an industrial antioxidant used primarily as an antiskinning agent in alkyd paint, was investigated in rats and rabbits. Following preliminary dose range finding studies, groups of 25 pregnan
Autor:
Anne F. Gilliam, Rochelle W. Tyl, William E. Rinehart, Melissa C. Marr, Michael J. Derelanko, James M. Gerhart, John C. Seely, Dolores R. Brine, Christina B. Myers
Publikováno v:
Fundamental and Applied Toxicology. 31:149-161
Methylethyl ketoxime (CAS No. 96-29-7; MEKO; 2-butanone oxime), an antioxidant agent used in paints, resins, and adhesives, was tested for reproductive toxicity in a two-generation study with CD (Sprague–Dawley) rats. Thirty-eight-week-old rats/sex
Autor:
Michael J. Derelanko
Publikováno v:
Journal of the American College of Toxicology. 13:314-320
Toxicologists are being called upon to educate the public about the value of toxicity testing and the important role animals play in this regard. This article discusses the importance of toxicologists educating students in the middle school about the
Autor:
Thomas M. Graczyk, Patrick J. Little, Diane L. DeHaven-Hudkins, William M. Barker, Michael Koblish, Rolf T. Windh, Minghua Gu, Marina S. Feschenko, Joel A. Cassel, Guo-Hua Chu, Daniel D. Wiant, Steve Kutz, Lara Kathryn Leister, Robert N. DeHaven, Serge Belanger, Bertrand Le Bourdonnec, Roland E. Dolle, Bernice L. Brogdon, Steven A. Smith, Tuthill Paul Anson, Michael J. Derelanko, Q. Jean Zhou, Christopher W. Ajello
Publikováno v:
Journal of medicinal chemistry. 52(18)
Selective, nonpeptidic delta opioid receptor agonists have been the subject of great interest as potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) contributed to the rapid expansion of research in this field. However, po