Efficient autocrine and paracrine signaling explain the osteogenic superiority of transgenic BMP-2 over rhBMP-2

Autor: Aysegul Atasoy-Zeybek, Michael J. Coenen, Gresin P. Hawse, Delphine Logeart-Avramoglou, Christopher H. Evans, Rodolfo E. De La Vega

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 350-363 (2023)

Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclin

Externí odkaz: https://doaj.org/article/a6616c8594034237bd2d18ec1d533163

Segmental defect healing in the presence or absence of recombinant human BMP2: Novel insights from a rat model

Autor: Joseph A. Panos, Michael J. Coenen, Christopher V. Nagelli, Erin B. McGlinch, Aysegul Atasoy‐Zeybek, Consuelo Lopez De Padilla, Rodolfo E. De la Vega, Christopher H. Evans

Publikováno v: Journal of Orthopaedic Research. Wiley

This study defined and compared the course of native, impaired and growth factor-stimulated bone regeneration in a rat femoral defect model. A mid-diaphyseal defect with rigid internal fixation was surgically created in the right femur of male Fische

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c7e42036a13b4727da3c50d628014f
https://doi.org/10.1002/jor.25530

Effects of FK506 on the healing of diaphyseal, critical size defects in the rat femur

Autor: R E De la Vega, C. Lopez De Padilla, Michael J. Coenen, Sebastian A Müller, C V Nagelli, N.P. Quirk, Christopher H. Evans

Publikováno v: European Cells & Materials, Vol 40, Pp 160-171 (2020)
European cells & materials
European Cells & Materials, 40, 160-171. AO Research Institute Davos (ARI)

There is much interest in understanding the influence of the immune system on bone healing, including a number of reports suggesting a beneficial effect of FK506 (tacrolimus) in this regard. The influence of FK506 in a rat, femoral, critical size def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16937d693a622047bd4eb53cf3242908
https://doi.org/10.22203/ecm.v040a10

Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2

Autor: Rodolfo E. De La Vega, Martijn van Griensven, Wen Zhang, Michael J. Coenen, Christopher V. Nagelli, Joseph A. Panos, Carlos J. Peniche Silva, Johannes Geiger, Christian Plank, Christopher H. Evans, Elizabeth R. Balmayor

Publikováno v: Science advances 8(7), 1-15 (2022). doi:10.1126/sciadv.abl6242
Science advances, 8(7):6242. American Association for the Advancement of Science

Science advances 8(7), 1-15 (2022). doi:10.1126/sciadv.abl6242
Published by American Association for the Advancement of Science, Washington, DC [u.a.]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308fb3df419779533d1935fc27dc0291

Picrosirius Red Staining: Revisiting Its Application to the Qualitative and Quantitative Assessment of Collagen Type I and Type III in Tendon

Autor: Sebastian A Müller, Rodolfo E. De la Vega, Christopher H. Evans, Consuelo M. Lopez De Padilla, Michael J. Coenen, Alejandro Tovar

Publikováno v: J Histochem Cytochem

Collagen has a major role in the structural organization of tendons. Picrosirius red (PSR) staining viewed under polarized light microscopy is the standard method to evaluate the organization of collagen fibers in tissues. It is also used to distingu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b66ce4c592d3230ed7b94a0366d33e1
https://pubmed.ncbi.nlm.nih.gov/34549650