Výsledky vyhledávání - "Michael J Ziller"

Akademický článek

Genomic distribution and inter-sample variation of non-CpG methylation across human cell types.

Autor: Michael J Ziller, Fabian Müller, Jing Liao, Yingying Zhang, Hongcang Gu, Christoph Bock, Patrick Boyle, Charles B Epstein, Bradley E Bernstein, Thomas Lengauer, Andreas Gnirke, Alexander Meissner

Publikováno v: PLoS Genetics, Vol 7, Iss 12, p e1002389 (2011)

DNA methylation plays an important role in development and disease. The primary sites of DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account for roughly three quarters of the total DNA methylation content in hu

Externí odkaz: https://doaj.org/article/90d0c1f60b0a45fe96f3ef51e7dc277f

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Akademický článek

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)

Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.

Externí odkaz: https://doaj.org/article/b648848b74c14840be9be48f8be10660

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Akademický článek

Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

Autor: Florian J. Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V. Glaser, Michael C. Wehr, Michael J. Ziller, Andrea Schmitt, Peter Falkai, Moritz J. Rossner

Publikováno v: Cells, Vol 11, Iss 2, p 241 (2022)

Oligodendrocytes (OLs) are critical for myelination and are implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression of different combinations of the

Externí odkaz: https://doaj.org/article/08b805a9fb834881ad230840bfd5a1b3

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Akademický článek

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

Autor: Chao Sheng, Johannes Jungverdorben, Hendrik Wiethoff, Qiong Lin, Lea J. Flitsch, Daniela Eckert, Matthias Hebisch, Julia Fischer, Jaideep Kesavan, Beatrice Weykopf, Linda Schneider, Dominik Holtkamp, Heinz Beck, Andreas Till, Ullrich Wüllner, Michael J. Ziller, Wolfgang Wagner, Michael Peitz, Oliver Brüstle

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related s

Externí odkaz: https://doaj.org/article/9c09e47ee2e347998c07481693058095

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Akademický článek

Genome-wide tracking of dCas9-methyltransferase footprints

Autor: Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller, Alexander Meissner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

Catalytically inactive Cas9 fused to a methyltransferase has emerged as a promising epigenome modifying tool. Here the authors generate a methylation depleted but maintenance competent mouse ES cell line and find ubiquitous off-target activity.

Externí odkaz: https://doaj.org/article/facfcb998fb94a91ab5dd5199cd3a1b4

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Akademický článek

Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development

Autor: Ryan M.J. Genga, Eric M. Kernfeld, Krishna M. Parsi, Teagan J. Parsons, Michael J. Ziller, René Maehr

Publikováno v: Cell Reports, Vol 27, Iss 3, Pp 708-718.e10 (2019)

Summary: Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key molecular aspects of human END regulation differ even from rodents. Differentiation of human

Externí odkaz: https://doaj.org/article/e7593eac1e9e4a069ad3b75b75374298

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Akademický článek

Information recovery from low coverage whole-genome bisulfite sequencing

Autor: Emanuele Libertini, Simon C. Heath, Rifat A. Hamoudi, Marta Gut, Michael J. Ziller, Agata Czyz, Victor Ruotti, Hendrik G. Stunnenberg, Mattia Frontini, Willem H. Ouwehand, Alexander Meissner, Ivo G. Gut, Stephan Beck

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)

Here, Libertini and colleagues devise a computation tool that can analyze whole-genome bisulfite sequencing (WGBS) data to recover of ∼30% of the lost differential methylation position information. They use COMETgazer and COMETvintage to analyze 13

Externí odkaz: https://doaj.org/article/270685d69411490d83bf90eb1cdafc89

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