Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Michael J Wester"'
Publikováno v:
Bioinformatics and Biology Insights, Vol 16 (2022)
We previously developed a method of defining receptor clusters in the membrane based on mutual distance and applied it to a set of transmission microscopy images of vascular endothelial growth factor receptors. An optimal length parameter was identif
Externí odkaz:
https://doaj.org/article/3f05bf47d0d04dd8bf04330e8cab2229
Autor:
Hanieh Mazloom-Farsibaf, Farzin Farzam, Mohamadreza Fazel, Michael J Wester, Marjolein B M Meddens, Keith A Lidke
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246138 (2021)
Visualizing actin filaments in fixed cells is of great interest for a variety of topics in cell biology such as cell division, cell movement, and cell signaling. We investigated the possibility of replacing phalloidin, the standard reagent for super-
Externí odkaz:
https://doaj.org/article/d49220088b1543d6b8ca295630a7ea46
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188599 (2017)
Candida albicans is a virulent human opportunistic pathogen. It evades innate immune surveillance by masking an immunogenic cell wall polysaccharide, β-glucan, from recognition by the immunoreceptor Dectin-1. Glucan unmasking by the antifungal drug
Externí odkaz:
https://doaj.org/article/395edde4584848808f78959241ad3886
Autor:
Michelle S Itano, Matthew S Graus, Carolyn ePehlke, Michael J Wester, Ping eLiu, Keith A Lidke, Nancy L Thompson, Ken eJacobson, Aaron K Neumann
Publikováno v:
Frontiers in Physics, Vol 2 (2014)
Dendritic cells express DC-SIGN and CD206, C-type lectins (CTLs) that bind a variety of pathogens and may facilitate pathogen uptake for subsequent antigen presentation. Both proteins form punctate membrane nanodomains (~80 nm) on naïve cells. We an
Externí odkaz:
https://doaj.org/article/3b53ccae7b03414281af8451095170f7
Autor:
Matthew S Graus, Carolyn Pehlke, Michael J Wester, Lisa B Davidson, Stanly L Steinberg, Aaron K Neumann
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 5, p e1003639 (2014)
To understand the process of innate immune fungal recognition, we developed computational tools for the rigorous quantification and comparison of receptor recruitment and distribution at cell-cell contact sites. We used these tools to quantify patter
Externí odkaz:
https://doaj.org/article/263374a4f4324948a34b06a4e2caeeef
Autor:
Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
Publikováno v:
Nature Biotechnology. 40:1509-1519
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect®, an approach to enhance the functional selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37adbdc10c2c7fdd110d991a2ca6fa2f
https://doi.org/10.1038/s41587-022-01384-1
https://doi.org/10.1038/s41587-022-01384-1
Autor:
Michael J. Wester, David J. Schodt, Hanieh Mazloom-Farsibaf, Mohamadreza Fazel, Sandeep Pallikkuth, Keith A. Lidke
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
We describe a robust, fiducial-free method of drift correction for use in single molecule localization-based super-resolution methods. The method combines periodic 3D registration of the sample using brightfield images with a fast post-processing alg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab24caefe6f01c8971c91ea03d21544b
https://doaj.org/article/475849048ed14e0398cdd277211aaefd
https://doaj.org/article/475849048ed14e0398cdd277211aaefd
Autor:
Michael J. Wester
Publikováno v:
Mathematics in Computer Science. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b83f418ab6b7208a9a1127ce70f6e54e
https://doi.org/10.1007/s11786-022-00541-8
https://doi.org/10.1007/s11786-022-00541-8
Autor:
Mohamadreza Fazel, Michael J. Wester, David J. Schodt, Sebastian Restrepo Cruz, Sebastian Strauss, Florian Schueder, Thomas Schlichthaerle, Jennifer M. Gillette, Diane S. Lidke, Bernd Rieger, Ralf Jungmann, Keith A. Lidke
Publikováno v:
Nature Communications, 13(1)
Single-molecule localization microscopy super-resolution methods rely on stochastic blinking/binding events, which often occur multiple times from each emitter over the course of data acquisition. Typically, the blinking/binding events from each emit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad6e89701cf437a8cac465d9691a4d5
https://pubmed.ncbi.nlm.nih.gov/36418347
https://pubmed.ncbi.nlm.nih.gov/36418347
Autor:
Diane S. Lidke, Keith A. Lidke, Julian A. Rojo, David J. Schodt, Michael J. Wester, Rachel M. Grattan, Emanuel Salazar-Cavazos, Elizabeth M. Bailey
Publikováno v:
J Vis Exp
Phosphorylation is a necessary posttranslational modification that regulates protein function and directs cell signaling outcomes. Current methods to measure protein phosphorylation cannot preserve the heterogeneity in phosphorylation across individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b92900651dda7c657ae070a1a454ebb
https://doi.org/10.3791/63665-v
https://doi.org/10.3791/63665-v