Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Michael J Tocci"'
2
A Cell-Based Protein-Protein Interaction Method Using a Permuted Luciferase Reporter
Autor: Praveen Sharma, Haifeng Eishingdrelo, Wright Paul S, Michael J Tocci, Jidong Cai, Paul Weissensee
Publikováno v: Current Chemical Genomics
We have developed a novel cell-based protein-protein interaction assay method. The method relies on conversion of an inactive permuted luciferase containing a Tobacco Etch Virus protease (TEV) cleavage sequence fused onto protein (A) to an active luc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e5b98d316e9f615c52b2a0b6958cfd
https://doi.org/10.2174/1875397301105010122
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3
GPR40 is partially required for insulin secretion following activation of β3-adrenergic receptors
Autor: Roberta Avallone, Zhen Pang, Michael J. Tocci, Pascual Ferrara, Holly Dressler, Xin Zhang, Tiziano Croci, H. Gregory Polites, Vaseem Palejwala, Nancy N. Wu
Publikováno v: Molecular and Cellular Endocrinology. 325:18-25
The free fatty acid (FFA) receptor GPR40, expressed by pancreatic beta-cells, may be responsible for insulin release following beta(3) adrenoceptor (Adrb3) activation. To test this hypothesis, we first studied the effects of Adrb3 agonists SR58611A a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1005f7ff503b0e5083eb0036ccd827a8
https://doi.org/10.1016/j.mce.2010.04.014
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5
The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding
Autor: Janey N. Parsons, Michael J. Tocci, Stephen J. O'Keefe, Margaret Pang, Hollis R. Williams, Betsy Frantz, Tracey Klatt, Anna M. Rolando, Edward A. O'Neill
Publikováno v: Biochemistry. 37:13846-13853
The serine/threonine kinase p38 is a ubiquitous, highly conserved, stress responsive, signal-transducing enzyme. It regulates the production of proinflammatory mediators and is the target of the cytokine synthesis inhibitory pyridinylimidazoles. We h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d084600d9d6efef50916e92dc2072085
https://doi.org/10.1021/bi980832y
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6
Expression and Immunoaffinity Purification of Human Inducible Nitric-oxide Synthase
Autor: David A. Geller, Ermenegilda McCauley, Michael J. Tocci, Timothy R. Billiar, Malcolm MacCoss, Andreas K. Nussler, Stephan K. Grant, Kenny K. Wong, Jimmy R. Calaycay, Theresa M. Kelly, Jeffrey R. Weidner, Patrick R. Griffin, S.M. Raju, Tracey Klatt, Shrenik K. Shah, Hongbo Qi, Richard A. Mumford, Gloria C. Wolfe, Hollis R. Williams, John A. Schmidt, Nancy I. Hutchinson, Karen L. MacNaul
Publikováno v: Journal of Biological Chemistry. 271:28212-28219
Recombinant human inducible nitric-oxide synthase (rH-iNOS) was expressed in the baculovirus system and purified by a novel immunoaffinity column. rH-iNOS and its native counterpart from cytokine-stimulated primary hepatocytes exhibited similar molec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4027a4d1d0842141651cc546b8598808
https://doi.org/10.1074/jbc.271.45.28212
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7
Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B
Autor: R.L. Kincaid, E.C. Nordby, N. Steffan, Edward A. O'Neill, Michael J. Tocci, G D Bren, Stephen J. O'Keefe, C.V. Paya, Betsy Frantz
Publikováno v: The EMBO Journal. 13:861-870
The interleukin-2 (IL-2) promoter consists of several independent T cell receptor (TcR) responsive elements. The induction of promoters dependent on these elements is inhibitable by the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK-506).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015f0de5867cb4971eaeca623a4ff64b
https://doi.org/10.1002/j.1460-2075.1994.tb06329.x
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8
The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice
Autor: Holly Dressler, Erica Schaffer, Vaseem Palejwala, Zhen Pang, Etienne Guillot, Daniel Weinstock, Chunpeng Fan, Xin Zhang, Souad Naimi, Jean Cavallo, Preeti Yamdagni, Michael J. Tocci, David C. Chain, Marie-Pierre Pruniaux, Kyriakos D. Economides, H. Greg Polites, Weiguang Zhao, Nancy N. Wu, Sarah Favara, Anne-Marie Galzin
Publikováno v: Obesity (Silver Spring, Md.). 19(10)
Cannabinoid receptor CB1 is expressed abundantly in the brain and presumably in the peripheral tissues responsible for energy metabolism. It is unclear if the antiobesity effects of rimonabant, a CB1 antagonist, are mediated through the central or th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0c3d386116fdb9e8b182d2e86e5996
https://pubmed.ncbi.nlm.nih.gov/21799481
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10
Unexpected up-regulation of gene expression by cyclosporin A and FK-506 in a T-cell lymphoma: Both immunosuppressants augment Ly-6E antigen induction by interferon-γ in the presence of ionomycin
Autor: Francis J. Dumont, Mary-Jo Staruch, Michael J. Tocci, Anne Altmeyer, Paul A. Fischer, Nolan H. Sigal, Philippe L. Durette
Publikováno v: International Journal of Immunopharmacology. 13:1187-1199
Cyclosporin A (CsA) and FK-506 inhibit lymphokine gene activation in T-cells. In the present study, we investigated the effects of these immunosuppressants on the regulation of a non-lymphokine molecule, the Ly-6E surface antigen, in the YAC-1 T-cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a249b704429e719fc943825f6e89aa17
https://doi.org/10.1016/0192-0561(91)90170-c
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