Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michael J Thomenius"'
Autor:
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kat Cosmopoulos, Alexandra R Grassian, Christine Klaus, Megan Foley, Elizabeth A Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E Mills, Scott Ribich, Margaret Porter Scott, Kevin W Kuntz, William P Janzen, Mikel Moyer, Jesse J Smith, Richard Chesworth, Robert A Copeland, P Ann Boriack-Sjodin
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://doaj.org/article/8d24a066e3c44272bf8a8c8842bb3428
Autor:
Michael J. Thomenius, Alejandra Raimondi, Scott A. Ribich, Sarah K. Knutson, Elayne Chan-Penebre, Heike Keilhack, Robert A. Copeland, Jesse J. Smith, Christopher Plescia, Igor Feldman, Natalie M. Warholic, Vinny Motwani, Trupti Lingaraj, Allison Drew, Danielle Johnston-Blackwell, Dorothy Brach
The EZH2 small-molecule inhibitor tazemetostat (EPZ-6438) is currently being evaluated in phase II clinical trials for the treatment of non-Hodgkin lymphoma (NHL). We have previously shown that EZH2 inhibitors display an antiproliferative effect in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16635ec96cb32a617f49970fa6370768
https://doi.org/10.1158/1535-7163.c.6539623.v1
https://doi.org/10.1158/1535-7163.c.6539623.v1
Autor:
Michael J. Thomenius, Alejandra Raimondi, Scott A. Ribich, Sarah K. Knutson, Elayne Chan-Penebre, Heike Keilhack, Robert A. Copeland, Jesse J. Smith, Christopher Plescia, Igor Feldman, Natalie M. Warholic, Vinny Motwani, Trupti Lingaraj, Allison Drew, Danielle Johnston-Blackwell, Dorothy Brach
Table S1: Conditions and seeding densities of all cell lines used in studies; Table S2. Single agent IC50 values for agents tested for 3 days in 96-well plates as described in Materials and Methods; Figure S1. Tazemetostat dosing reduced H3K27me3 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028053566081cf3c139a50ed258075a7
https://doi.org/10.1158/1535-7163.22510432
https://doi.org/10.1158/1535-7163.22510432
Autor:
Gabriel J. Sandoval, Katharine Feldman, Sal Topal, Ammar Adam, Hsin-Jung Wu, Darshan Sappal, Luis M. Soares, David L. Lahr, Lan Xu, Rishi G. Vaswani, Jordana Muwanguzi, Liyue Huang, Jessica Piel, Mike Collins, Ho Man Chan, Michael J. Thomenius, Steven F. Bellon, Ryan G. Kruger, Carl P. Decicco, Richard C. Centore, Martin Hentemann
Publikováno v:
Cancer Research. 82:LB190-LB190
SPI1 (PU.1) is an ETS family transcription factor that plays a critical role in hematopoietic development and differentiation. Regulation of SPI1 expression has also been implicated in Acute Myeloid Leukemia (AML) oncogenesis, though its mechanism is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::275371575ca144b436a9541a469cc338
https://doi.org/10.1158/1538-7445.am2022-lb190
https://doi.org/10.1158/1538-7445.am2022-lb190
Autor:
Thomas V. Riera, Lampe John W, Cuyue Tang, Kat Cosmopoulos, Alejandra Raimondi, Michael John Munchhof, Neil A. Farrow, Kenneth W. Duncan, Dorothy Brach, Vinny Motwani, Darren Martin Harvey, P. Ann Boriak-Sjodin, Sean T. Eckley, Jennifer Totman, Joshua S Alford, Megan Alene Cloonan Foley, Michael J Thomenius
Publikováno v:
ACS Medicinal Chemistry Letters
SET domain-containing protein 2 (SETD2), a histone methyltransferase, has been identified as a target of interest in certain hematological malignancies, including multiple myeloma. This account details the discovery of EPZ-719, a novel and potent SET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c70d3b49c7dd565ec207bc48d880872
https://pubmed.ncbi.nlm.nih.gov/34671445
https://pubmed.ncbi.nlm.nih.gov/34671445
Autor:
Chih-Sheng Yang, Christopher B. Newgard, Wanli Tang, Jonathan L. Coloff, Erika Segear Johnson, Christopher D. Freel, Jie An, Jeffrey C. Rathmell, Judy Qiju Wu, Olga Ilkayeva, Sarah R. Horn, Sally Kornbluth, Michael J. Thomenius
Publikováno v:
Molecular Biology of the Cell
Mitochondria form an interconnected network that undergoes dynamin-related protein 1 (Drp1)-dependent fission during mitosis. We demonstrate that changes in mitochondrial dynamics as cells exit mitosis are driven through ubiquitylation of Drp1 by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cf18ca0c824de5656fd7cabef55c72
https://doi.org/10.1091/mbc.e10-07-0567
https://doi.org/10.1091/mbc.e10-07-0567
Autor:
S Balasundaram, Christopher D. Freel, R Cannon, Michael J. Thomenius, Kristin White, Ronald J. Krieser, Sally Kornbluth, Eltyeb Abdelwahid, Sarah R. Horn
Publikováno v:
Cell Death and Differentiation
In most multicellular organisms, the decision to undergo programmed cell death in response to cellular damage or developmental cues is typically transmitted through mitochondria. It has been suggested that an exception is the apoptotic pathway of Dro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d29ccad0d2cd9848565c9c85e07212
https://doi.org/10.1038/cdd.2011.26
https://doi.org/10.1038/cdd.2011.26
Autor:
Kat Cosmopoulos, Kenneth W. Duncan, Lampe John W, J. Joshua Smith, Thomas V. Riera, Neil A. Farrow, Richard Chesworth, Lei Ci, Dorothy Brach, Michael J Thomenius, Jennifer Totman, Cuyue Tang
Publikováno v:
Blood. 132:3207-3207
t(4;14) chromosome translocations are found in 15% of newly diagnosed multiple myeloma (MM) cases and are associated with high risk. MM cells with t(4;14) over-express the histone methyltransferase (HMT), WHSC1/MMSET/NSD2, which leads to deregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b4a81f7fbd2ffa0247c25750a988d1
https://doi.org/10.1182/blood-2018-99-110803
https://doi.org/10.1182/blood-2018-99-110803
Autor:
D. Ashley Richardson, Christopher D. Freel, Sally Kornbluth, Michael R. Olson, Eugene C. Gan, Michael J. Thomenius, Sarah R. Horn
Publikováno v:
Journal of Biological Chemistry. 283:367-379
Morphological hallmarks of apoptosis result from activation of the caspase family of cysteine proteases, which are opposed by a pro-survival family of inhibitors of apoptosis proteins (IAPs). In Drosophila, disruption of IAP function by Reaper, HID,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39747b07a214de0fc47670ca29a55fb3
https://doi.org/10.1074/jbc.m708931200
https://doi.org/10.1074/jbc.m708931200
Autor:
Michael J. Thomenius, Sally Kornbluth
Publikováno v:
Cell Death & Differentiation. 13:1305-1309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f77bbeff88518d1f6e95f7670ee048
https://doi.org/10.1038/sj.cdd.4401954
https://doi.org/10.1038/sj.cdd.4401954