Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Michael J Sweredoski"'
Autor:
William T Ireland, Suzannah M Beeler, Emanuel Flores-Bautista, Nicholas S McCarty, Tom Röschinger, Nathan M Belliveau, Michael J Sweredoski, Annie Moradian, Justin B Kinney, Rob Phillips
Publikováno v:
eLife, Vol 9 (2020)
Advances in DNA sequencing have revolutionized our ability to read genomes. However, even in the most well-studied of organisms, the bacterium Escherichia coli, for ≈65% of promoters we remain ignorant of their regulation. Until we crack this regul
Externí odkaz:
https://doaj.org/article/a102a55ccecf4145acbb0d068fc98190
Autor:
Spencer Hill, Kurt Reichermeier, Daniel C Scott, Lorena Samentar, Jasmin Coulombe-Huntington, Luisa Izzi, Xiaojing Tang, Rebeca Ibarra, Thierry Bertomeu, Annie Moradian, Michael J Sweredoski, Nora Caberoy, Brenda A Schulman, Frank Sicheri, Mike Tyers, Gary Kleiger
Publikováno v:
eLife, Vol 8 (2019)
The cullin-RING ligases (CRLs) form the major family of E3 ubiquitin ligases. The prototypic CRLs in yeast, called SCF enzymes, employ a single E2 enzyme, Cdc34, to build poly-ubiquitin chains required for degradation. In contrast, six different huma
Externí odkaz:
https://doaj.org/article/98a68f538710454382335ba50adf32c3
Autor:
Grigor Varuzhanyan, Rebecca Rojansky, Michael J Sweredoski, Robert LJ Graham, Sonja Hess, Mark S Ladinsky, David C Chan
Publikováno v:
eLife, Vol 8 (2019)
Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis. Acutely after depletion of mitofusins Mfn1 and Mfn2, spermatog
Externí odkaz:
https://doaj.org/article/bea96b69c3024295bb0ecb0861f2d75c
Autor:
Min-Kyung Sung, Tanya R Porras-Yakushi, Justin M Reitsma, Ferdinand M Huber, Michael J Sweredoski, André Hoelz, Sonja Hess, Raymond J Deshaies
Publikováno v:
eLife, Vol 5 (2016)
Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1. tom1
Externí odkaz:
https://doaj.org/article/44ad927e6bbf49ea8eb9522bc2eca76c
Autor:
Ruzbeh Mosadeghi, Kurt M Reichermeier, Martin Winkler, Anne Schreiber, Justin M Reitsma, Yaru Zhang, Florian Stengel, Junyue Cao, Minsoo Kim, Michael J Sweredoski, Sonja Hess, Alexander Leitner, Ruedi Aebersold, Matthias Peter, Raymond J Deshaies, Radoslav I Enchev
Publikováno v:
eLife, Vol 5 (2016)
The COP9-Signalosome (CSN) regulates cullin–RING ubiquitin ligase (CRL) activity and assembly by cleaving Nedd8 from cullins. Free CSN is autoinhibited, and it remains unclear how it becomes activated. We combine structural and kinetic analyses to
Externí odkaz:
https://doaj.org/article/687ae2c8181c46b19f44a743b621a9d9
Autor:
Angelica M Riestra, Shiv Gandhi, Michael J Sweredoski, Annie Moradian, Sonja Hess, Sinisa Urban, Patricia J Johnson
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005294 (2015)
Trichomonas vaginalis is an extracellular eukaryotic parasite that causes the most common, non-viral sexually transmitted infection worldwide. Although disease burden is high, molecular mechanisms underlying T. vaginalis pathogenesis are poorly under
Externí odkaz:
https://doaj.org/article/d0aea1e73a124808b276bec7485bacc9
Autor:
Jessica A. Griffiths, Bryan B. Yoo, Peter Thuy-Boun, Victor J. Cantu, Kelly C. Weldon, Collin Challis, Michael J. Sweredoski, Ken Y. Chan, Taren M. Thron, Gil Sharon, Annie Moradian, Gregory Humphrey, Qiyun Zhu, Justin P. Shaffer, Dennis W. Wolan, Pieter C. Dorrestein, Rob Knight, Viviana Gradinaru, Sarkis K. Mazmanian
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113953- (2024)
Summary: The gastrointestinal (GI) tract is innervated by intrinsic neurons of the enteric nervous system (ENS) and extrinsic neurons of the central nervous system and peripheral ganglia. The GI tract also harbors a diverse microbiome, but interactio
Externí odkaz:
https://doaj.org/article/8903257bb5ea472f893d149c894884a6
Autor:
Chun-Shik Shin, Shuxia Meng, Spiros D. Garbis, Annie Moradian, Robert W. Taylor, Michael J. Sweredoski, Brett Lomenick, David C. Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Most mitochondrial proteins are imported from the cytosol and must fold in the mitochondria. Here, the authors show that the mitochondrial protease LONP1 plays a critical role in the mtHSP70 chaperone system independently of its protease activity.
Externí odkaz:
https://doaj.org/article/8a65c368ecc04a4481d331a0a80d8431
Autor:
Brenda M. Molgora, Anand Kumar Rai, Michael J. Sweredoski, Annie Moradian, Sonja Hess, Patricia J. Johnson
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The ability of the sexually transmitted parasite Trichomonas vaginalis
Externí odkaz:
https://doaj.org/article/cb268fb518a6420cb0d472cbc1d6b297
Autor:
Brett M. Babin, Lydia Atangcho, Mark B. van Eldijk, Michael J. Sweredoski, Annie Moradian, Sonja Hess, Tim Tolker-Nielsen, Dianne K. Newman, David A. Tirrell
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Biofilm infections exhibit high tolerance against antibiotic treatment. The study of biofilms is complicated by phenotypic heterogeneity; biofilm subpopulations differ in their metabolic activities and their responses to antibiotics. Here, w
Externí odkaz:
https://doaj.org/article/304e4d5b63f845a58cf8ae5331b0818c