Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Michael J Spinella"'
Autor:
Doha Shokry, Mehwish W. Khan, Christine Powell, Samantha Johnson, Brayden C. Rennels, Raya I. Boyd, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Maryanna H. Parker, Miranda D. Vieson, Jonathan P. Samuelson, Michael J. Spinella, Ratnakar Singh
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number of cisplatin-resistant patients die from progressive disease as no effective alternatives exist. Curative cisplatin the
Externí odkaz:
https://doaj.org/article/68755ecf9402453293b42c650e2ab10c
Autor:
Pingping Mao, Mary P Hever-Jardine, Gilbert J Rahme, Eric Yang, Janice Tam, Anita Kodali, Bijesh Biswal, Camilo E Fadul, Arti Gaur, Mark A Israel, Michael J Spinella
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81803 (2013)
STK17A is a relatively uncharacterized member of the death-associated protein family of serine/threonine kinases which have previously been associated with cell death and apoptosis. Our prior work established that STK17A is a novel p53 target gene th
Externí odkaz:
https://doaj.org/article/b111648a7d7944d39d3c1b8d7e97f07d
Autor:
Bijesh K Biswal, Maroun J Beyrouthy, Mary P Hever-Jardine, David Armstrong, Craig R Tomlinson, Brock C Christensen, Carmen J Marsit, Michael J Spinella
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53003 (2012)
Human embryonal carcinoma (EC) cells are the stem cells of nonseminoma testicular germ cells tumors (TGCTs) and share remarkable similarities to human embryonic stem (ES) cells. In prior work we found that EC cells are hypersensitive to low nanomolar
Externí odkaz:
https://doaj.org/article/a03afb36e5c4405b938a6654ddcf4d3a
Autor:
Kelly C Heim, Joshua J Gamsby, Mary P Hever, Sarah J Freemantle, Jennifer J Loros, Jay C Dunlap, Michael J Spinella
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7639 (2009)
Mechanisms that underlie oscillatory transcriptional activity of nuclear receptors (NRs) are incompletely understood. Evidence exists for rapid, cyclic recruitment of coregulatory complexes upon activation of nuclear receptors. RIP140 is a NR coregul
Externí odkaz:
https://doaj.org/article/2d1f7ad0450446ba93ba15964ad48fed
Autor:
Andrea K. Corbet, Emmanuel Bikorimana, Raya I. Boyd, Doha Shokry, Kelly Kries, Ayush Gupta, Anneliese Paton, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Erik R. Nelson, Michael J. Spinella, Ratnakar Singh
Publikováno v:
Translational Oncology, Vol 33, Iss , Pp 101676- (2023)
G0/G1 switch gene 2 (G0S2) is known to inhibit lipolysis by inhibiting adipose triglyceride lipase (ATGL). In this report, we dissect the role of G0S2 in ER+ versus ER- breast cancer. Overexpression of G0S2 in ER- cells increased cell proliferation,
Externí odkaz:
https://doaj.org/article/cbcbc9b7c9dc4ba880141b3cdbbac673
Autor:
Raya I. Boyd, Doha Shokry, Zeeshan Fazal, Brayden C. Rennels, Sarah J. Freemantle, Michael R. La Frano, Gail S. Prins, Zeynep Madak Erdogan, Joseph Irudayaraj, Ratnakar Singh, Michael J. Spinella
Publikováno v:
Toxics, Vol 12, Iss 4, p 232 (2024)
The potential effects of poly- and perfluoroalkyl substances (PFAS) are a recently emergent human and environmental health concern. There is a consistent link between PFAS exposure and cancer, but the mechanisms are poorly understood. Although epidem
Externí odkaz:
https://doaj.org/article/63bec03f1c444472b4882a8ed84927b2
Autor:
Ratnakar Singh, Zeeshan Fazal, Emmanuel Bikorimana, Raya I. Boyd, Cliff Yerby, Megan Tomlin, Hannah Baldwin, Doha Shokry, Andrea K. Corbet, Khadeeja Shahid, Aleyah Hattab, Sarah J. Freemantle, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Externí odkaz:
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef
Autor:
Zeeshan Fazal, Ratnakar Singh, Fang Fang, Emmanuel Bikorimana, Hannah Baldwin, Andrea Corbet, Megan Tomlin, Cliff Yerby, Nabil Adra, Costantine Albany, Sarah Lee, Sarah J. Freemantle, Kenneth P Nephew, Brock C Christensen, Michael J. Spinella
Publikováno v:
Epigenetics, Vol 16, Iss 10, Pp 1071-1084 (2021)
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, altho
Externí odkaz:
https://doaj.org/article/4b7b7223caa54e218dd20f2ec7342e9a
Publikováno v:
Toxics, Vol 11, Iss 1, p 32 (2022)
Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important or
Externí odkaz:
https://doaj.org/article/22a7c4db8e524a4a890d2fb3c4c29575
Autor:
Sarah J. Freemantle, Megan Tomlin, Khadeeja Shahid, Andrea K. Corbet, Aleyah Hattab, Emmanuel Bikorimana, Hannah Baldwin, Raya I. Boyd, Ratnakar Singh, Cliff Yerby, Doha Shokry, Zeeshan Fazal, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Molecular Oncology
Molecular Oncology
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ddf3799002302ee27479edca374322
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef