Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Michael J Shattock"'
Autor:
Mingjie Bai, Emily Gallen, Sarah Memarzadeh, Jacqueline Howie, Xing Gao, Chien-Wen S Kuo, Elaine Brown, Simon Swingler, Sam J Wilson, Michael J Shattock, David J France, William Fuller
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299665 (2024)
Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral me
Externí odkaz:
https://doaj.org/article/4fde80e1212443ac90281f207fa24630
Autor:
Yu Jin Chung, Zoe Hoare, Friedrich Baark, Chak Shun Yu, Jia Guo, William Fuller, Richard Southworth, Doerthe Katschinski, Michael P. Murphy, Thomas R. Eykyn, Michael J. Shattock
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 10, Iss , Pp 100108- (2024)
Externí odkaz:
https://doaj.org/article/ec7d30ade53f4faea7757d290d0164cb
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 10, Iss , Pp 100117- (2024)
Externí odkaz:
https://doaj.org/article/add60a7bd1d2476595351fb895d1b7e9
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25250 (2011)
Diet-induced obesity in rat pregnancy has been shown previously to be associated with consistently raised blood pressure in the offspring, attributed to sympathetic over-activation, but the relative contributions to this phenotype of maternal obesity
Externí odkaz:
https://doaj.org/article/276aaaea0be046b3a3099109cd85d6d9
Autor:
Andrew R. Hall, Qutuba G. Karwi, Sanjeev Kumar, Rachel Dongworth, Dunja Aksentijević, Tariq R. Altamimi, Kevin Timothy Fridianto, Kroekkiat Chinda, Sauri Hernandez-Resendiz, Mohammad U. Mahmood, Evangelos Michelakis, Chrishan J. Ramachandra, Jianhong Ching, Jose M. Vicencio, Michael J. Shattock, Jean-Paul Kovalik, Derek M. Yellon, Gary Lopaschuk, Derek J. Hausenloy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury (IRI) but the mechanisms are unknown. Here, we investigate the role of the mitochondrial NAD+-dependent deacetylase, Sirtuin-3 (SIRT3), which has been shown to
Externí odkaz:
https://doaj.org/article/3a9998b09ea84a4bb20bc74a3baad146
Autor:
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://doaj.org/article/7cbe5c5a5f744ee8954ab054d0919e50
Autor:
Dunja Aksentijević, Anja Karlstaedt, Marina V. Basalay, Brett A. O’Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel A. Tennant, William Fuller, Thomas R. Eykyn, Heinrich Taegtmeyer, Michael J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprogra
Externí odkaz:
https://doaj.org/article/01651cc80f9b4aad9898d7152d51f740
Autor:
Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphoryl
Externí odkaz:
https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
Publikováno v:
Journal of molecular and cellular cardiology
Elevated intracellular Na (Nai) and metabolic impairment are interrelated pathophysiological features of the failing heart (HF). There have been a number of studies showing that myocardial sodium elevation subtly affects mitochondrial function. Durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bf1564769d4f3a937ecb3e11f2c69e
https://doi.org/10.1016/j.yjmcc.2021.08.003
https://doi.org/10.1016/j.yjmcc.2021.08.003
Autor:
Alice Main, Andri Bogusalvskyii, Jacqueline Howie, Chien-wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70822cf6eb2faffd02fabc5cc956e698
https://doi.org/10.1101/2022.08.19.504400
https://doi.org/10.1101/2022.08.19.504400
