Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Michael J Rogers"'
Autor:
Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, Mark P Hodson, Shuting Sun, Frank H Ebetino, David R Croucher, Philip M Hansbro, Jacqueline R Center, Michael J Rogers
Publikováno v:
eLife, Vol 10 (2021)
Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to r
Externí odkaz:
https://doaj.org/article/efd2366c282f45e0a4b6b5d87db2968d
Autor:
Sumedh Kamble, Peter Valtchev, Aiken Dao, Théophile Pelras, Michael J Rogers, Paul B. Savage, Fariba Dehghani, Aaron Schindeler
Publikováno v:
Molecules, Vol 26, Iss 6, p 1541 (2021)
Osteomyelitis and orthopedic infections are major clinical problems, limited by a lack of antibiotics specialized for such applications. In this paper, we describe the design and synthesis of a novel bone-binding antibiotic (BBA-1) and its subsequent
Externí odkaz:
https://doaj.org/article/7343433dfa6846d09fff380253623840
Autor:
Michael J Rogers, Marcia A Munoz
Publikováno v:
eLife, Vol 7 (2018)
Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
Externí odkaz:
https://doaj.org/article/7f37ee7d28e24f24b8e187fb8fd1a30d
Autor:
Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma K. Fletcher, Esther Kristianto, Mark P. Hodson, Seán I. O’Donoghue, Sandeep Kaur, Robert Brink, David G. Zahra, Elissa K. Deenick, Kristen A. Perry, Avril A.B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)
Mevalonate kinase deficiency (MKD) is characterized by recurrent fevers and flares of systemic inflammation, caused by biallelic loss-of-function mutations in MVK. The underlying disease mechanisms and triggers of inflammatory flares are poorly under
Externí odkaz:
https://doaj.org/article/21b5b88799f3482d9c5c720c2d6c2ea8
Publikováno v:
American Journal of Biological Anthropology. 181:206-215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0feb58ed08c9a1b717e83dd9cbc0d3ff
https://doi.org/10.1002/ajpa.24717
https://doi.org/10.1002/ajpa.24717
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf662da78ed20d5cf712db233a51417
https://doi.org/10.1158/2159-8290.22530387
https://doi.org/10.1158/2159-8290.22530387
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in 4T1 breast tumour.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f217b10600e0c556fba992180f86e9df
https://doi.org/10.1158/2159-8290.22530384.v1
https://doi.org/10.1158/2159-8290.22530384.v1
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Supplementary Figure S1. Fluorescently-labelled bisphosphonate is present in the macrophage-rich region of 4T1 mammary tumours in vivo. Supplementary Figure S2. N-BP colocalises with microcalcifications, detected by calcein labelling in 4T1 mammary t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea65363343626e12a65ac8a89ee1cc9
https://doi.org/10.1158/2159-8290.22530390.v1
https://doi.org/10.1158/2159-8290.22530390.v1
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in normal breast tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d2e44bee539cb34a25591f6bc40d47
https://doi.org/10.1158/2159-8290.22530381
https://doi.org/10.1158/2159-8290.22530381
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
3D reconstruction of 4T1 mammary tumour 24 hours after injection of bisphosphonate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b6dd46a0a0ddd480f45ce4f18af456
https://doi.org/10.1158/2159-8290.22530372.v1
https://doi.org/10.1158/2159-8290.22530372.v1