Zobrazeno 1 - 10 of 273 pro vyhledávání: '"Michael J Reed"'
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Akademický článek
STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice.
Autor: Florence Meyer-Losic, Simon P Newman, Joanna M Day, Michael J Reed, Philip G Kasprzyk, Atul Purohit, Paul A Foster
Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80305 (2013)
Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX) caused by severe dose limiting toxicities, such as neu
Externí odkaz: https://doaj.org/article/72fc20d8905647e1aed52f755a02a4f3
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4
Correction: Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level
Autor: Michael J. Reed, Rebecca Baillie, Meghan McCabe Pryor, Ronald B. Moss, Dennis J. Carlo, Katherine Kudrycki, Christina M. Friedrich
Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0234683 (2020)
Rapid resuscitation of an opioid overdose with naloxone, an opioid antagonist, is critical. We developed an opioid receptor quantitative systems pharmacology (QSP) model for evaluation of naloxone dosing. In this model we examined three opioid exposu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230b7cef856cc4bc4bd4d5374b14479c
http://europepmc.org/articles/PMC7297366
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5
Correlating thyroid cytology and histopathology: Implications for molecular testing
Autor: Robert A. Robinson, Michael P. Gailey, Steven M. Sperry, Michael J. Reed, Gerry F. Funk, Nitin A. Pagedar, Chris S. Jensen
Publikováno v: Head & Neck. 38:1104-1106
Background A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Methods Retrospectively, all cy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5abdeb9820e4617aff0b4b1daf912df8
https://doi.org/10.1002/hed.24410
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The Role of Women in Dental Education: Monitoring the Pipeline to Leadership
Autor: Ann Marie Corry, Michael J. Reed, Ying Liu
Publikováno v: Journal of Dental Education. 76:1427-1436
The purpose of this study was to analyze data collected by the American Dental Association and the American Dental Education Association over the past two decades relating to changes in the number of women active in dental education and dental practi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae7cf3338472f28351429182bf26b50d
https://doi.org/10.1002/j.0022-0337.2012.76.11.tb05403.x
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Correlating thyroid cytology and histopathology: Implications for molecular testing
Autor: Michael J, Reed, Steven M, Sperry, Michael P, Gailey, Chris S, Jensen, Robert A, Robinson, Gerry F, Funk, Nitin A, Pagedar
Publikováno v: Headneck. 38(7)
A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center.Retrospectively, all cytologically indeterm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db2afce6c2602d5276f9b98f8b5313ba
https://pubmed.ncbi.nlm.nih.gov/26900030
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Synthesis, Antitubulin, and Antiproliferative SAR of Analogues of 2-Methoxyestradiol-3,17-O,O-bis-sulfamate
Autor: Simon P. Newman, Fabrice Jourdan, Barry V. L. Potter, Mathew P. Leese, Eric Ferrandis, Ernest Hamel, Atul Purohit, Wolfgang Dohle, Michael J. Reed
Publikováno v: Journal of Medicinal Chemistry. 53:2942-2951
The synthesis and antiproliferative activity of analogues of estradiol 3,17-O,O-bis-sulfamates (E2bisMATEs) are discussed. Modifications of the C-17 substituent reveal that an H-bond acceptor is essential for high antiproliferative activity. The loca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2d8de42356653eeea337adeff04475
https://doi.org/10.1021/jm9018806
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The Development of Steroid Sulfatase Inhibitors for Hormone-Dependent Cancer Therapy
Autor: Joanna M. Day, Michael J. Reed, Helena J. Tutill, Barry V. L. Potter, Atul Purohit, L. W. Lawrence Woo, Paul A. Foster
Publikováno v: Annals of the New York Academy of Sciences. 1155:80-87
Steroid sulfatase (STS) regulates the hydrolysis of steroid sulfates to their unconjugated forms. Estrone sulfate and dehydroepiandrosterone sulfate can be hydrolyzed by STS to estrone and dehydroepiandrosterone, respectively, with these steroids bei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bddd2ba71501558c1868d2d428f657c
https://doi.org/10.1111/j.1749-6632.2008.03677.x
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BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure
Autor: Y T Ho, A. Purohit, Helena J. Tutill, Michael J. Reed, Simon P. Newman, Paul A. Foster, M P Leese, Joanna M. Day, Barry V. L. Potter
Publikováno v: British Journal of Cancer
The anti-proliferative and anti-angiogenic properties of the endogenous oestrogen metabolite, 2-methoxyoestradiol (2-MeOE2), are enhanced in a series of sulphamoylated derivatives of 2-MeOE2. To investigate possible mechanisms of resistance to these
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac84982bd2533d2cde737d922ac5616
https://doi.org/10.1038/sj.bjc.6604873
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